全文获取类型
收费全文 | 497篇 |
免费 | 79篇 |
国内免费 | 2篇 |
专业分类
耳鼻咽喉 | 3篇 |
儿科学 | 38篇 |
妇产科学 | 11篇 |
基础医学 | 70篇 |
临床医学 | 43篇 |
内科学 | 164篇 |
皮肤病学 | 5篇 |
神经病学 | 65篇 |
特种医学 | 17篇 |
外科学 | 28篇 |
综合类 | 6篇 |
预防医学 | 20篇 |
眼科学 | 34篇 |
药学 | 12篇 |
肿瘤学 | 62篇 |
出版年
2022年 | 3篇 |
2021年 | 3篇 |
2020年 | 4篇 |
2019年 | 10篇 |
2018年 | 4篇 |
2017年 | 12篇 |
2016年 | 7篇 |
2015年 | 5篇 |
2014年 | 9篇 |
2013年 | 12篇 |
2012年 | 15篇 |
2011年 | 21篇 |
2010年 | 10篇 |
2009年 | 9篇 |
2008年 | 20篇 |
2007年 | 24篇 |
2006年 | 15篇 |
2005年 | 16篇 |
2004年 | 19篇 |
2003年 | 20篇 |
2002年 | 17篇 |
2001年 | 19篇 |
2000年 | 18篇 |
1999年 | 17篇 |
1998年 | 7篇 |
1997年 | 4篇 |
1996年 | 4篇 |
1994年 | 8篇 |
1992年 | 13篇 |
1991年 | 12篇 |
1990年 | 10篇 |
1989年 | 13篇 |
1988年 | 11篇 |
1987年 | 18篇 |
1986年 | 16篇 |
1985年 | 21篇 |
1984年 | 7篇 |
1983年 | 11篇 |
1982年 | 15篇 |
1981年 | 13篇 |
1980年 | 5篇 |
1979年 | 22篇 |
1978年 | 12篇 |
1977年 | 8篇 |
1976年 | 9篇 |
1975年 | 4篇 |
1972年 | 4篇 |
1970年 | 3篇 |
1965年 | 2篇 |
1946年 | 2篇 |
排序方式: 共有578条查询结果,搜索用时 561 毫秒
1.
2.
D I Boxer 《The British journal of radiology》1988,61(723):267-268
3.
3-Carboxy-3,4-dehydropyrrolidine was found to bind with affinity equal to that of glycine in a [3H]strychnine binding assay. Simple substitution of the 1-, 2-, 4-, or 5-position resulted in marked loss of affinity. A decline in affinity was also found upon enlargement, contraction, or saturation of the 5-membered ring. However, beta-proline and azetidine-3-carboxylic acid retained significant binding affinity. Despite its good affinity in [3H]strychnine binding, 3-carboxy-3,4-dehydropyrrolidine showed only weak agonist activity in intracellular recordings of cultured murine spinal cord neurons. This apparent lack of correlation between binding and functional results is discussed in light of the current models of the strychnine-sensitive glycine receptor. 相似文献
4.
5.
Life expectancy in British Marfan syndrome populations 总被引:2,自引:0,他引:2
JR Gray AB Bridges RR West L. McLeish AG Stuart JCS Dean MEM Porteous M. Boxer SJ Davies 《Clinical genetics》1998,54(2):124-128
A total of 206 patients with Marfan syndrome were ascertained throughout genetic clinics in Wales and Scotland during the period 1970–1990. There were 45 deaths representing 22% of the cohort. Mean age at death was 45.3 ± 16.5 years. 50% median cumulative survival in the total cohort (n = 206) was 53 years for males and 72 years for females. Multivariate analysis confirmed severity as the best independent indicator of survival. These findings and survival curves will assist in the counselling of British families and individuals with Marfan syndrome. 相似文献
6.
L A Boxer J M Oliver S P Spielberg J M Allen J D Schulman 《The New England journal of medicine》1979,301(17):901-905
The administration of vitamin E (alpha-tocopherol) was found to improve polymorphonuclear leukocyte function in an infant with congenital deficiency of glutathione synthetase activity. Before therapy with vitamin E the abnormal leukocytes exposed to phagocytic challenge showed oxidant damage. They released 60 per cent more hydrogen peroxide than did normal leukocytes, iodinated only 20 to 25 per cent of the normal number of particles, and were unable to kill bacteria as effectively as normal leukocytes although the rates of phagocytosis were normal. These functional abnormalities disappeared when the patient was placed on 400 IU of alpha-tocopherol daily for three months. Associated with the functional improvement was a normalization of microtubule assembly during phagocytic challenge. 相似文献
7.
Z L Zhou S X Cai E R Whittemore C S Konkoy S A Espitia M Tran D M Rock L L Coughenour J E Hawkinson P A Boxer C F Bigge L D Wise E Weber R M Woodward J F Keana 《Journal of medicinal chemistry》1999,42(15):2993-3000
A structure-based search and screen of our compound library identified N-(2-phenoxyethyl)-4-benzylpiperidine (8) as a novel N-methyl-D-aspartate (NMDA) receptor antagonist that has high selectivity for the NR1/2B subunit combination (IC(50) = 0.63 microM). We report on the optimization of this lead compound in terms of potency, side effect liability, and in vivo activity. Potency was assayed by electrical recordings in Xenopus oocytes expressing cloned rat NMDA receptors. Side effect liability was assessed by measuring affinity for alpha(1)-adrenergic receptors and inhibition of neuronal K(+) channels. Central bioavailability was gauged indirectly by determining anticonvulsant activity in a mouse maximal electroshock (MES) assay. Making progressive modifications to 8, a hydroxyl substituent on the phenyl ring para to the oxyethyl tether (10a) resulted in a approximately 25-fold increase in NR1A/2B potency (IC(50) = 0.025 microM). p-Methyl substitution on the benzyl ring (10b) produced a approximately 3-fold increase in MES activity (ED(50) = 0.7 mg/kg iv). Introduction of a second hydroxyl group into the C-4 position on the piperidine ring (10e) resulted in a substantial decrease in affinity for alpha(1) receptors and reduction in inhibition of K(+) channels with only a modest decrease in NR1A/2B and MES potencies. Among the compounds described, 10e (4-hydroxy-N-[2-(4-hydroxyphenoxy)ethyl]-4-(4-methylbenzyl)piperid ine, Co 101244/PD 174494) had the optimum pharmacological profile and was selected for further biological evaluation. 相似文献
8.
Oriented properties of the chlorophylls: Electronic absorption spectroscopy of orthorhombic pyrochlorophyllide a-apomyoglobin single crystals 总被引:2,自引:1,他引:1
下载免费PDF全文
![点击此处可从《Proceedings of the National Academy of Sciences of the United States of America》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Boxer SG Kuki A Wright KA Katz BA Xuong NH 《Proceedings of the National Academy of Sciences of the United States of America》1982,79(4):1121-1125
The orientations of the transition dipole moments in chlorophyll (Chl) are among the most useful spectroscopic properties for determining macromolecular architecture in photosynthetic complexes; however, the relationships between these orientations and the Chl molecular geometry are unknown. In order to solve this problem, we have prepared single crystals of the synthetic 1:1 complex between pyrochlorophyllide a and apomyoglobin. The protein crystallizes readily in the orthorhombic (B) form, space group P212121, and the unit cell dimensions are determined to be within 0.5% of those for native MetMb crystals of the same type. These green crystals are highly dichroic, and the strong absorption along the crystallographic a axis in the Qy band is red-shifted by about 9 nm, relative to the corresponding feature in a solution of the protein. Although the crystal structure for native Mb in this space group has not been determined, the direction cosines of the heme normal relative to the crystal axes have been measured. By using these values, an appropriate trigonometric analysis, and the measured polarized single-crystal spectra, the orientation of the Chl transition dipole moment for the Qy transition can be specified relative to the crystal axes. With the completion of the protein crystal structure, this result will lead directly to the orientations of the optical transition dipole moments relative to the molecular geometry. The effects of vibronic coupling and the protein environment on the absorption properties of Chl are discussed in detail. 相似文献
9.
Anisotropic magnetic interactions in the primary radical ion-pair of photosynthetic reaction centers 总被引:2,自引:2,他引:0
下载免费PDF全文
![点击此处可从《Proceedings of the National Academy of Sciences of the United States of America》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Boxer SG Chidsey CE Roelofs MG 《Proceedings of the National Academy of Sciences of the United States of America》1982,79(15):4632-4636
The quantum yield of triplets formed by ion-pair recombination in quinone-depleted photosynthetic reaction centers is found to depend on their orientation in a magnetic field. This new effect is expected to be a general property of radical pair reactions in the solid state. For 0 < H < 1,000 G, the quantum yield anisotropy is caused by anisotropic electron dipole-electron dipole or nuclear hyperfine interactions, or both. For high fields it is dominated by the anisotropy of the difference g-tensor in the radical ion-pair. The magnitude and sign of the contribution of each interaction depend not only on the values of the principal components of each anisotropic tensor but also on the geometric relationship of the principal axes of each tensor to the transition dipole moment used to detect the yield. A detailed formalism is presented relating these quantities to the observed yield anisotropy. The expected magnitude of each anisotropic parameter is discussed. It is demonstrated that the field dependence of the yield anisotropy is consistent with these values for certain reaction center geometries. 相似文献
10.
A.G. Bibas A.Gh. Podoleanu R.G. Cucu M. Bonmarin G.M. Dobre V.M.M. Ward E. Odell A. Boxer M.J. Gleeson D.A. Jackson 《Clinical otolaryngology》2004,29(6):713-720
Laryngeal carcinoma is one of the commonest primary head and neck malignancy and the need for early identification is very important for successful treatment. Outpatient fibreoptic examination of the larynx is unreliable in differentiating benign, pre‐malignant and malignant lesions, and therefore surgeons have to rely on biopsies for a definitive diagnosis. This is an invasive procedure requiring general anaesthesia and may have a detrimental effect on the patient's voice. Conventional imaging modalities (ultrasound, computed tomography and magnetic resonance imaging) have a limited resolution and hence cannot give sufficient information on the extent or nature of laryngeal lesions. The aim of our study is to investigate the feasibility of optical coherence tomography (OCT) in imaging the normal larynx, to lay the foundations for an investigation of its ability to differentiate between benign and malignant disease. Ten tissue specimens from normal larynges were imaged with an 850 nm OCT system that was capable of providing both B‐scan (longitudinal or cross‐section) images as well as C‐scan (en‐face or images at constant depth). The en‐face OCT mode allowed us to reconstruct 3‐D OCT images of the tissue examined. Imaged specimens were processed with standard histopathological techniques and sectioned in the plane of the B‐scan OCT images. Haematoxylin–eosin stained specimens were compared with the OCT images thus collected. Preliminary results showed good correlation between OCT images and histology sections in normal tissue. 相似文献