全文获取类型
收费全文 | 3976篇 |
免费 | 244篇 |
国内免费 | 7篇 |
专业分类
耳鼻咽喉 | 23篇 |
儿科学 | 335篇 |
妇产科学 | 115篇 |
基础医学 | 446篇 |
口腔科学 | 113篇 |
临床医学 | 236篇 |
内科学 | 1056篇 |
皮肤病学 | 108篇 |
神经病学 | 173篇 |
特种医学 | 99篇 |
外科学 | 572篇 |
综合类 | 144篇 |
一般理论 | 1篇 |
预防医学 | 159篇 |
眼科学 | 107篇 |
药学 | 202篇 |
中国医学 | 6篇 |
肿瘤学 | 332篇 |
出版年
2023年 | 23篇 |
2022年 | 54篇 |
2021年 | 133篇 |
2020年 | 67篇 |
2019年 | 98篇 |
2018年 | 131篇 |
2017年 | 96篇 |
2016年 | 123篇 |
2015年 | 118篇 |
2014年 | 150篇 |
2013年 | 197篇 |
2012年 | 312篇 |
2011年 | 324篇 |
2010年 | 191篇 |
2009年 | 117篇 |
2008年 | 235篇 |
2007年 | 248篇 |
2006年 | 201篇 |
2005年 | 181篇 |
2004年 | 162篇 |
2003年 | 142篇 |
2002年 | 154篇 |
2001年 | 89篇 |
2000年 | 110篇 |
1999年 | 76篇 |
1998年 | 43篇 |
1997年 | 31篇 |
1996年 | 25篇 |
1995年 | 23篇 |
1994年 | 23篇 |
1993年 | 13篇 |
1992年 | 36篇 |
1991年 | 48篇 |
1990年 | 24篇 |
1989年 | 38篇 |
1988年 | 22篇 |
1987年 | 24篇 |
1986年 | 15篇 |
1985年 | 16篇 |
1984年 | 12篇 |
1983年 | 14篇 |
1981年 | 7篇 |
1980年 | 6篇 |
1979年 | 5篇 |
1977年 | 6篇 |
1976年 | 12篇 |
1974年 | 5篇 |
1972年 | 8篇 |
1971年 | 5篇 |
1966年 | 4篇 |
排序方式: 共有4227条查询结果,搜索用时 15 毫秒
1.
Apoorva Challa Neeraj Mahajan Seema Sood Arti Kapil Bimal Kumar Das Vishnubhatla Sreenivas Somesh Gupta 《Indian journal of medical microbiology》2022,40(3):433-435
Treatment guidelines for management of uncomplicated gonorrhoeae have been recently modified owing to alarming upsurge in azithromycin resistance. This study investigated the prevalence and genetic determinants of gonococcal azithromycin resistance in India. Four (5.7%) of 70 gonococcal isolates were resistant to azithromycin. Of 16 isolates investigated for molecular mechanisms of resistance, 13 (81.3%) and 6 (37.5%) isolates exhibited mutations in coding and promoter regions of mtrR gene, respectively. However, ermA, ermB and ermC genes or mutations in rrl gene were absent in all isolates. Azithromycin resistance is low in India posing no immediate threat to use of dual-therapy for syndromic management. 相似文献
2.
Bimal Bhindi Christine M. Lohse Phillip J. Schulte Ross J. Mason John C. Cheville Stephen A. Boorjian Bradley C. Leibovich R. Houston Thompson 《European urology》2019,75(5):766-772
Background
Partial nephrectomy (PN) is generally favored for cT1 tumors over radical nephrectomy (RN) when technically feasible. However, it can be unclear whether the additional risks of PN are worth the magnitude of renal function benefit.Objective
To develop preoperative tools to predict long-term estimated glomerular filtration rate (eGFR) beyond 30 d following PN and RN, separately.Design, setting, and participants
In this retrospective cohort study, patients who underwent RN or PN for a single nonmetastatic renal tumor between 1997 and 2014 at our institution were identified. Exclusion criteria were venous tumor thrombus and preoperative eGFR <15 ml/min/1.73 m2.Intervention
RN and PN.Outcome measurements and statistical analysis
Hierarchical generalized linear mixed-effect models with backward selection of candidate preoperative features were used to predict long-term eGFR following RN and PN, separately. Predictive ability was summarized using marginal , which ranges from 0 to 1, with higher values indicating increased predictive ability.Results and limitations
The analysis included 1152 patients (13 206 eGFR observations) who underwent RN and 1920 patients (18 652 eGFR observations) who underwent PN, with mean preoperative eGFRs of 66 ml/min/1.73 m2 (standard deviation [SD] = 18) and 72 ml/min/1.73 m2 (SD = 20), respectively. The model to predict eGFR after RN included age, diabetes, preoperative eGFR, preoperative proteinuria, tumor size, time from surgery, and an interaction between time from surgery and age (marginal ). The model to predict eGFR after PN included age, presence of a solitary kidney, diabetes, hypertension, preoperative eGFR, preoperative proteinuria, surgical approach, time from surgery, and interaction terms between time from surgery and age, diabetes, preoperative eGFR, and preoperative proteinuria (marginal ). Limitations include the lack of data on renal tumor complexity and the single-center design; generalizability needs to be confirmed in external cohorts.Conclusions
We developed preoperative tools to predict renal function outcomes following RN and PN. Pending validation, these tools should be helpful for patient counseling and clinical decision-making.Patient summary
We developed models to predict kidney function outcomes after partial and radical nephrectomy based on preoperative features. This should help clinicians during patient counseling and decision-making in the management of kidney tumors. 相似文献3.
4.
Surender Kumar Yachha Rakesh Aggarwal S Srinivas Anshu Srivastava Sanjay K Somani Srivenu Itha 《Indian journal of gastroenterology》2006,25(3):132-135
BACKGROUND: We prospectively evaluated the usefulness of IgA tissue transglutaminase antibodies (IgA tTG) in the initial diagnosis of celiac disease (CD) and compared its diagnostic potential with that of IgA anti-endomysial antibodies (IgA EMA) and anti-IgA and IgG gliadin antibodies (AGA and AGG, respectively). METHODS: Sera of 23 untreated children fulfilling the revised ESPGHAN criteria for diagnosis of CD (Group I; mean age 10.8 y); 19 disease controls (Group II; mean age 8.5 y) presenting with chronic diarrhea, short stature or both; and 22 healthy children (Group III; mean age 8.8 y) were studied. These were tested in a blinded manner for AGA, AGG, IgA tTG (guinea pig as antigen) and IgA EMA. RESULTS: In Group I, IgA EMA was positive in 19, IgA tTG in 17, AGA in 14 and AGG in 17 patients. In Group II, these tests were positive in 1, 0, 2 and 14 patients, respectively and in Group III, in 0, 0, 0 and 1 child, respectively. Analyzing data from Group I and II, IgA EMA, IgA tTG, AGA and AGG had sensitivity rates of 83%, 74%, 61% and 74%, respectively; the specificity rates were 95%, 100%, 89% and 26%; positive predictive values were 95%, 100%, 88% and 55% and negative predictive values were 82%, 74%, 65% and 45%, respectively. CONCLUSION: IgA tTG is useful for the diagnosis of CD, with sensitivity and specificity rates comparable to those of EMA and this test is well suited for use in tropical countries like India. 相似文献
5.
6.
P Aggarwal S K Sharma A B Dey T K Chattopadhyay M Mathur 《Postgraduate medical journal》1989,65(770):929-931
A case of malignant fibrous histiocytoma of the mediastinum presenting with unusual features of fever and leucocytosis is reported. This is the youngest patient reported in the literature who had this tumour in the mediastinum. 相似文献
7.
8.
Dhawan Subhash; Puri Raj K.; Kumar Ashok; Duplan Helen; Masson Jean-Michel; Aggarwal Bharat B. 《Blood》1997,90(4):1535-1544
9.
Synthesis and biological evaluation of prodrugs of zidovudine 总被引:4,自引:0,他引:4
A series of prodrugs of zidovudine (AZT) has been synthesized in an effort to enhance the uptake of the prodrugs by the HIV-1 infected cells and to increase the plasma half-life of AZT. The 5'-OH function of AZT was esterified with various acids in the presence of DCC and 4-(dimethylamino)pyridine (DMAP). The prodrug moieties included (a) morpholine and N-phenylpiperazine-1-acetic acid, (b) 1,4-dihydro-1-methyl-3-nicotinic acid, (c) retinoic acid, and (d) certain amino acids. The anti-HIV-1 activity of the esters was determined in peripheral blood lymphocytes. The IC50 for AZT in this system was 0.12 microM whereas for prodrugs it ranged from 0.05 to 0.2 microM. The prodrugs were generally less cytotoxic than AZT except the retinoic acid ester. In vitro hydrolysis of the various esters in human plasma indicated that these agents were relatively stable toward plasma esterases with t1/2 ranging from 10 to 240 min. Drug uptake studies in H9 cells with radiolabeled analogues demonstrated that the retinoic acid ester achieved approximately 4-fold higher intracellular concentration than [3H]AZT. However, 1,4-dihydro-1-methyl-3-[(pyridylcarbonyl)oxy] ester (5) was the most active agent of this series and had a higher therapeutic index than AZT. 相似文献
10.
Georgios Amoiridis Ludwig Gutmann Dennis E. Wilkins Raja Sawaya Alain Lagueny Roger Marthan Philippe Schuermans Philippe Le Collen Xavier Ferrer Jean Julien Reha Kuruoglu Shin J. Oh Brian Thompson A. Aggarwal L. Gutmann A. Gutierrez Okifumi Nakazato Russel Johnsen Philip Morling B. A. Kakulas 《Muscle & nerve》1994,17(2):245-253