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H. Betuel L. Gebuhrer L. Descos H. Percebois Y. Minaire J. Bertrand 《Tissue antigens》1980,15(3):231-238
Celiac disease (CD), which occurs in Europe with varying frequency, is known to be associated with HLA-B8 and even more strongly with HLA-Dw3 because of the high linkage disequilibrium between these two antigens. After typing for HLA-A, ∼B and -DR antigens in adult patients with CD, we can confirm the high prevalence of B8 (72.7%) and of DRw3 (63.7%). However we find that DRw7 is also significantly increased (54.5%); DRw3 and DRw7, taken together, represent 86% of our 22 patients. 相似文献
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Autoreactive T cell clones specific for class I and class II HLA antigens isolated from a human chimera 总被引:1,自引:1,他引:1 下载免费PDF全文
M G Roncarolo H Yssel J L Touraine H Betuel J E De Vries H Spits 《The Journal of experimental medicine》1988,167(5):1523-1534
T cell clones of donor origin that specifically react with recipient cells were obtained from a SCID patient successfully reconstituted by allogeneic fetal liver and thymus transplantation performed 10 yr ago. The majority of these clones displayed both cytotoxic and proliferative responses towards PBL and an EBV-transformed B cell line derived from the patient. In addition, these T cell clones had proliferative and cytotoxic responses towards the parental PBL, EBV cell lines, and PHA blasts. Blocking studies with anti-class I and anti-class II HLA mAbs indicated that the activity of the CD4+ T cell clones was specifically directed against class II HLA antigens of the recipient. On the other hand, the cytotoxic and proliferative responses of the CD8+ T cell clones were specific for class I HLA antigens which are ubiquitously expressed on the recipient cells. Thus, the establishment of transplantation tolerance observed in this stable human chimera is not due to the elimination of host-reactive T cells from the repertoire and suggests the presence of a peripheral autoregulatory suppressor mechanism. 相似文献
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Inhibition of the mixed lymphocyte reaction by antibodies 总被引:4,自引:0,他引:4
J P Revillard M Robert H Betuel M Latour M Bonneau J Brochier J Traeger 《Transplantation proceedings》1972,4(2):173-176
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