全文获取类型
收费全文 | 3007篇 |
免费 | 244篇 |
国内免费 | 4篇 |
专业分类
耳鼻咽喉 | 15篇 |
儿科学 | 104篇 |
妇产科学 | 93篇 |
基础医学 | 443篇 |
口腔科学 | 38篇 |
临床医学 | 444篇 |
内科学 | 569篇 |
皮肤病学 | 38篇 |
神经病学 | 297篇 |
特种医学 | 75篇 |
外科学 | 285篇 |
综合类 | 48篇 |
一般理论 | 1篇 |
预防医学 | 366篇 |
眼科学 | 25篇 |
药学 | 182篇 |
中国医学 | 5篇 |
肿瘤学 | 227篇 |
出版年
2023年 | 15篇 |
2022年 | 29篇 |
2021年 | 66篇 |
2020年 | 40篇 |
2019年 | 51篇 |
2018年 | 58篇 |
2017年 | 61篇 |
2016年 | 52篇 |
2015年 | 68篇 |
2014年 | 83篇 |
2013年 | 118篇 |
2012年 | 185篇 |
2011年 | 219篇 |
2010年 | 106篇 |
2009年 | 108篇 |
2008年 | 185篇 |
2007年 | 178篇 |
2006年 | 216篇 |
2005年 | 187篇 |
2004年 | 179篇 |
2003年 | 154篇 |
2002年 | 158篇 |
2001年 | 57篇 |
2000年 | 61篇 |
1999年 | 56篇 |
1998年 | 31篇 |
1997年 | 32篇 |
1996年 | 21篇 |
1995年 | 25篇 |
1994年 | 22篇 |
1993年 | 17篇 |
1992年 | 35篇 |
1991年 | 22篇 |
1990年 | 25篇 |
1989年 | 29篇 |
1988年 | 18篇 |
1987年 | 25篇 |
1986年 | 20篇 |
1985年 | 23篇 |
1984年 | 16篇 |
1983年 | 26篇 |
1982年 | 14篇 |
1981年 | 18篇 |
1979年 | 10篇 |
1978年 | 16篇 |
1977年 | 11篇 |
1975年 | 7篇 |
1970年 | 6篇 |
1969年 | 7篇 |
1967年 | 7篇 |
排序方式: 共有3255条查询结果,搜索用时 140 毫秒
1.
Recognizing and managing a deteriorating patient: a randomized controlled trial investigating the effectiveness of clinical simulation in improving clinical performance in undergraduate nursing students
下载免费PDF全文
![点击此处可从《Journal of advanced nursing》网站下载免费的PDF全文](/ch/ext_images/free.gif)
2.
3.
Betsy D. Kennard Susan G. Silva Simon Tonev Paul Rohde Jennifer L. Hughes Benedetto Vitiello Christopher J. Kratochvil John F. Curry Graham J. Emslie Mark Reinecke John March 《Journal of the American Academy of Child and Adolescent Psychiatry》2009,48(2):186-195
ObjectiveWe examine remission rate probabilities, recovery rates, and residual symptoms across 36 weeks in the Treatment for Adolescents with Depression Study (TADS).MethodThe TADS, a multisite clinical trial, randomized 439 adolescents with major depressive disorder to 12 weeks of treatment with fluoxetine, cognitive–behavioral therapy, their combination, or pill placebo. The pill placebo group, treated openly after week 12, was not included in the subsequent analyses. Treatment differences in remission rates and probabilities of remission over time are compared. Recovery rates in remitters at weeks 12 (acute phase remitters) and 18 (continuation phase remitters) are summarized. We also examined whether residual symptoms at the end of 12 weeks of acute treatment predicted later remission.ResultsAt week 36, the estimated remission rates for intention-to-treat cases were as follows: combination, 60%; fluoxetine, 55%; cognitive–behavioral therapy, 64%; and overall, 60%. Paired comparisons reveal that, at week 24, all active treatments converge on remission outcomes. The recovery rate at week 36 was 65% for acute phase remitters and 71% for continuation phase remitters, with no significant between-treatment differences in recovery rates. Residual symptoms at the end of acute treatment predicted failure to achieve remission at weeks 18 and 36.ConclusionsMost depressed adolescents in all three treatment modalities achieved remission at the end of 9 months of treatment. 相似文献
4.
Sheela R Geraghty Barbara S Davidson Barbara B Warner Amy L Sapsford Jeanne L Ballard Betsy A List Rachel Akers Ardythe L Morrow 《Journal of human lactation》2005,21(1):59-66
Although there are well-established clinical human milk banks in the United States, there are no milk banks specifically intended to foster research on human milk. The authors' goal was to establish a milk bank with a core data set to support exploratory and hypothesis-driven studies on human milk. Donations to the Cincinnati Children's Research Human Milk Bank are accepted within the context of ongoing, hypothesis-driven research or on an ad hoc basis. Donors must give informed consent, and scientists wishing to use the samples must have Institutional review board approval for their use. Development of more research human milk banks can potentially provide resources for multidisciplinary collaboration and advance the study of human milk and lactation. 相似文献
5.
S Lori Brown Roselie A Bright Diane E Dwyer Betsy Foxman 《Journal of human lactation》2005,21(2):169-174
Breast pumps are medical devices used to express milk and maintain the milk supply. The purpose of this study was to characterize adverse events reported to the United States Food and Drug Administration (FDA) on breast pumps. Thirty-seven adverse event reports on breast pumps were identified from the Manufacturer and User Facility Device Experience database between 1992 and 2003. Four additional reports were found in the Device Experience Network database from 1992 to 1996. The most commonly reported adverse events for electric breast pumps were pain, soreness, or discomfort; the need for medical intervention; and breast tissue damage. Most frequently reported problems for manual breast pumps were breast tissue damage and infection. Contamination of breast milk during pumping was also reported. Breast pump adverse events are likely underreported to the FDA. Reporting adverse events is important for improving the design and manufacture of breast pumps and subsequently decreasing adverse events. 相似文献
6.
Proposed Report on the Educational Qualifications of Sanitarians. Committe on Professional Education
7.
Several psychophysiological abnormalities associated with schizophrenia have been proposed as genetic trait markers of vulnerability to the disorder. Smooth pursuit eye tracking dysfunction and abnormal long latency event-related potentials are the most promising candidates. Both are independent of the effects of psychotropic medication or mental state at the time of testing, and twin studies demonstrate that each has a high level of heritability. Having recorded smooth pursuit eye tracking and event-related potentials in 20 high-density schizophrenic families, we find abnormalities in one or both measures in most of the families studied. The abnormalities, when present, occur in the family members with schizophrenia and other forms of functional psychosis, and they have a bimodal distribution with approximately half the nonschizophrenic relatives also showing eye tracking dysfunction and/or abnormal event-related potentials. Some of these relatives had psychiatric symptoms; others were normal. Our results suggest that psychophysiological examination can help to clarify the boundaries of schizophrenia spectrum disorder. By helping to decide the phenotypic status of nonschizophrenic family members, this should increase the power of DNA linkage studies. 相似文献
8.
American Diabetes Association The initial draft of this paper was prepared by Rebecca G. Schafer MS RD ; Betsy Bohannon MS RD; Marion J. Franz MS RD; Janine Freeman RD; Alberta Holmes MS RD; Sue McLaughlin RD; Linda B. Haas RN; Davida F. Kruger MSN RN; Rodney A. Lorenz MD; Molly M.McMahon MD 《Journal of the American Dietetic Association》1997,97(1):52-53
9.
Vectorization of morpholino oligomers by the (R-Ahx-R)4 peptide allows efficient splicing correction in the absence of endosomolytic agents. 总被引:1,自引:0,他引:1
Sa?d Abes Hong M Moulton Philippe Clair Paul Prevot Derek S Youngblood Rebecca P Wu Patrick L Iversen Bernard Lebleu 《Journal of controlled release》2006,116(3):304-313
The efficient and non-toxic nuclear delivery of steric-block oligonucleotides (ON) is a prerequisite for therapeutic strategies involving splice correction or exon skipping. Cationic cell penetrating peptides (CPPs) have given rise to much interest for the intracellular delivery of biomolecules, but their efficiency in promoting cytoplasmic or nuclear delivery of oligonucleotides has been hampered by endocytic sequestration and subsequent degradation of most internalized material in endocytic compartments. In the present study, we compared the splice correction activity of three different CPPs conjugated to PMO(705), a steric-block ON targeted against the mutated splicing site of human beta-globin pre-mRNA in the HeLa pLuc705 splice correction model. In contrast to Tat48-60 (Tat) and oligoarginine (R(9)F(2)) PMO(705) conjugates, the 6-aminohexanoic-spaced oligoarginine (R-Ahx-R)(4)-PMO(705) conjugate was able to promote an efficient splice correction in the absence of endosomolytic agents. Our mechanistic investigations about its uptake mechanisms lead to the conclusion that these three vectors are internalized using the same endocytic route involving proteoglycans, but that the (R-Ahx-R)(4)-PMO(705) conjugate has the unique ability to escape from lysosomial fate and to access to the nuclear compartment. This vector, which has displays an extremely low cytotoxicity, the ability to function without chloroquine adjunction and in the presence of serum proteins. It thus offers a promising lead for the development of vectors able to enhance the delivery of therapeutic steric-block ON in clinically relevant models. 相似文献
10.
Long-latency auditory event-related potentials in schizophrenia and in bipolar and unipolar affective disorder. 总被引:1,自引:0,他引:1
Long-latency auditory event-related potentials were examined in 96 subjects with schizophrenia, 99 with bipolar affective disorder and 48 with major depressive (unipolar) disorder, and compared with 32 in-patient and 213 normal controls. The latency of the P3 component was significantly greater in the schizophrenic and bipolar subjects compared to other groups. The difference was stable with respect to clinical state at the time of testing and was not due to age differences or the effect of psychotropic medications. The results support the clinical distinction between bipolar and unipolar affective disorders, but also show that P3 change is not specific to schizophrenia and found in bipolar but not unipolar affective disorder. 相似文献