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1.
Betina N?rager Mirza Husic Jacob E M?ller Kenneth Egstrup 《Journal of the American Society of Echocardiography》2004,17(7):732-738
BACKGROUND: Wall-motion analysis during low-dose dobutamine echocardiography (LDDE) is a semiquantitative measure of left ventricular contractile reserve after myocardial infarction (MI). The Doppler echocardiographic myocardial performance index (MPI) is a quantitative measure of combined left ventricular systolic and diastolic function. We sought to characterize the changes in MPI during LDDE in control subjects and patients with MI, and to describe the relation of these changes to changes in regional systolic function. METHODS: MPI was obtained at rest and during LDDE (10 microg/kg/min) in 25 healthy volunteers (group 1) and 50 patients with a recent MI. Patients were divided into two subsets; those with (n = 23; group 2A) and those without (n = 27; group 2B) a contractile reserve defined as an improvement of wall motion in more than two contiguous infarct-zone segments during LDDE. DeltaMPI was defined as the change from rest to LDDE. RESULTS: MPI decreased significantly during LDDE in groups 1 and 2A, whereas MPI increased in group 2B (DeltaMPI = 0.12 +/- 0.04 and 0.10 +/- 0.08 vs -0.03 +/- 0.08, P <.0001). On multivariate analysis, Deltawall-motion score index predicted DeltaMPI (beta = 0.65, P <.0001) independently of age, sex, and the dobutamine-induced change in heart rate and systolic blood pressure. CONCLUSIONS: Data suggest that the change in MPI during LDDE may provide a simple and quantitative measure of overall left ventricular functional reserve in patients with a recent MI. 相似文献
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Anders Elias Hansen Frederikke Petrine Fliedner Jonas Rosager Henriksen Jesper Tranekjær Jørgensen Andreas Ettrup Clemmensen Betina Børresen Dennis Ringkjøbing Elema Andreas Kjær Thomas Lars Andresen 《Nanomedicine : nanotechnology, biology, and medicine》2018,14(1):27-34
Radiation therapy may affect several important parameters in the tumor microenvironment and thereby influence the accumulation of liposomes by the enhanced permeability and retention (EPR)-effect. Here we investigate the effect of single dose radiation therapy on liposome tumor accumulation by PET/CT imaging using radiolabeled liposomes. Head and neck cancer xenografts (FaDu) and syngenic colorectal (CT26) cancer models were investigated. Radiotherapy displayed opposite effects in the two models. FaDu tumors displayed increased mean accumulation of liposomes for radiation doses up to 10 Gy, whereas CT26 tumors displayed a tendency for decreased accumulation. Tumor hypoxia was found negatively correlated to microregional distribution of liposomes. However, liposome distribution in relation to hypoxia was improved at lower radiation doses. The study reveals that the heterogeneity in liposome tumor accumulation between tumors and different radiation protocols are important factors that need to be taken into consideration to achieve optimal effect of liposome based radio-sensitizer therapy. 相似文献
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Betina Santos Tomaz Gabriela Carvalho Gomes Juliana Arcanjo Lino David Guabiraba Abitbol de Menezes Jorge Barbosa Soares Vasco Furtado Luiz Soares Júnior Maria do Socorro Quintino Farias Debora Lilian Nascimento Lima Eanes Delgado Barros Pereira Marcelo Alcantara Holanda 《Jornal brasileiro de pneumologia》2022,48(1)
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Smoking Is a Risk Factor for Recurrence of Groin Hernia 总被引:15,自引:0,他引:15
Sorensen LT Friis E Jorgensen T Vennits B Andersen BR Rasmussen GI Kjaergaard J 《World journal of surgery》2002,26(4):397-400
Studies of connective tissue from
patients with inguinal hernia have shown that smoking may be associated
with hernia formation due to a defective connective tissue metabolism.
Whether smoking is a risk factor for recurrence, too, was examined in
this study. From December 1990 through December 1995, 649 patients
underwent hernia repair as open sutured repair (Cooper ligament or
abdominal ring repair) or as open mesh repair. Five hundred forty-four
eligible patients were evaluated for recurrence 2 years
postoperatively. Association between recurrence and 17 patient-,
disease-, and intraoperative variables were analyzed by multiple
logistic regression. The results showed that smoking was significantly
and independently associated with recurrence compared to nonsmoking
[odds ratio (OR = 2.22; 95% confidence interval (95% CI) =
1.19–4.15)]. Open sutured repair compared to open mesh repair was the
most significant predictor for recurrence (OR = 7.23; 95% CI
= 3.01–17.37). Surprisingly, local anesthesia was associated with a
higher risk of recurrence compared to general anesthesia (OR =
2.44; 95% CI = 1.19–5.09). Potential confounders and other risk
factors for hernia recurrence such as age, alcohol consumption,
previous surgery, and anatomical characteristics of the hernia were
adjusted for in the analysis. In conclusion, smoking is an important
risk factor for recurrence of groin hernia, presumably due to an
abnormal connective tissue metabolism in smokers. 相似文献