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排序方式: 共有261条查询结果,搜索用时 22 毫秒
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Adelekan AM Prozesky EA Hussein AA Ureña LD van Rooyen PH Liles DC Meyer JJ Rodríguez B 《Journal of natural products》2008,71(11):1919-1922
A new indanone derivative (1) and two new diterpenoids (2 and 3), together with three known flavonoids, have been isolated from an ethanol extract of the leaves of Croton steenkampianus. The structure of 2 was solved by single-crystal X-ray diffraction analysis, whereas those of 1 and 3 were established mainly by 1D and 2D NMR spectroscopic methods. The isolated compounds were tested for their antiplasmodial activity and cytotoxicity. Antiplasmodial assays against chloroquine-susceptible strains (D10 and D6) and the chloroquine-resistant strains (Dd2 and W2) of Plasmodium falciparum showed that compound 2 gave moderate activities at 9.1-15.8 μM, while none of the compounds were cytotoxic against Vero cells. 相似文献
3.
Ochoa-Brust GJ Fernández AR Villanueva-Ruiz GJ Velasco R Trujillo-Hernández B Vásquez C 《Acta obstetricia et gynecologica Scandinavica》2007,86(7):783-787
OBJECTIVE: To evaluate the role a daily intake of 100 mg of ascorbic acid plays in urinary infection prophylaxis during pregnancy. METHODS AND MATERIALS: A single-blind clinical trial was carried out on pregnant women randomly assigned to the following treatment groups - Group A: oral treatment with ferrous sulphate (200 mg per day), folic acid (5 mg per day) and ascorbic acid (100 mg per day) for 3 months, and Group B: oral treatment with ferrous sulphate (200 mg per day) and folic acid (5 mg per day) for 3 months. All patients were clinically evaluated, and a urine culture was carried out each month for a period of 3 months. The chi(2) and odds ratio were used to compare effects with and without ascorbic acid, and statistical significance was considered at p<0.05. RESULTS: Global frequency of urinary infections was 25%. The presence of urinary infections in Group A (12.7%) was significantly lower than in Group B (29.1%), (p=0.03, OR =0.35, CI 95% =0.13-0.91). CONCLUSIONS: Daily intake of 100 mg of ascorbic acid played an important role in the reduction of urinary infections, improving the health level of the gestating women. We recommend additional vitamin C intake for pregnant women in populations which have a high incidence of bacteriuria and urinary infections. 相似文献
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Armando Pérez-Rangel José Manuel Hernández Araceli Castillo-Romero Lilián Yépez-Mulia Rafael Castillo Francisco Hernández-Luis Benjamín Nogueda-Torres Juan Pedro Luna-Arias Gerardo Radilla Gloria León-Avila 《Parasitology research》2013,112(9):3251-3257
In the present study, we evaluated the effect of an albendazole (ABZ) derivative JVG9 on cultured Giardia intestinalis. To assess the JVG9 effects, we evaluated the tubulin cytoskeleton by confocal microscopy, and we found that the characteristic staining was modified. The scanning electron microscopy images revealed extremely damaged trophozoites and cyst-like cells. The confocal images revealed that this drug triggered the expression of cyst wall protein 1 and encystation. We also found that at low doses, AL triggered the encystation process too. 相似文献
6.
Casademont J Rodriguez-Santiago B Miró O Beato A López S Nunes V Cardellach F 《Aging clinical and experimental research》2005,17(1):1-7
BACKGROUND AND AIMS: The potential influence of impaired oxidative metabolism in the modulation of manifestations in sporadic Alzheimer's disease (AD) has attracted much attention in the last 50 years. Unfortunately, many clinical and experimental results aiming at proving this hypothesis are still controversial. The aim was to study the enzymatic activities of respiratory chain (RC) complexes I through V in three brain areas of a group of patients with definite AD, and to compare the results with a group of normal brains. We simultaneously assessed the lipid peroxidation of the samples as a measure of free radical damage. METHODS: The specific activity of the individual complexes of the RC was measured spectrophotometrically, and the loss of cis-parinaric acid fluorescence was used to determine the chemical process of lipid peroxidation. RESULTS: We were not able to detect differences in any of the analyzed RC enzymatic activities, or in the level of lipid peroxidation between patients with AD and controls. Instead, differences were found in the number of mitochondria and in the intrinsic enzymatic activities of complexes III and IV in various brain areas. CONCLUSIONS: Spectrophotometric enzymatic analyses of respiratory complexes in brain homogenates do not support the primary contribution of mitochondrial RC dysfunction in the pathogenesis of AD. 相似文献
7.
Anti-Trypanosoma cruzi and anti-leishmanial activity by quinoxaline-7-carboxylate 1,4-di-N-oxide derivatives 总被引:1,自引:0,他引:1
Juan Carlos Villalobos-Rocha Luvia Sánchez-Torres Benjamín Nogueda-Torres Aldo Segura-Cabrera Carlos A. García-Pérez Virgilio Bocanegra-García Isidro Palos Antonio Monge Gildardo Rivera 《Parasitology research》2014,113(6):2027-2035
In this work, a novel series of ethyl and methyl quinoxaline-7-carboxylate 1,4-di-N-oxide derivatives were evaluated in vitro on Trypanosoma cruzi trypomastigotes and Leishmania mexicana promastigotes, and cytotoxicity activity in murine macrophages was tested. In silico molecular docking simulations of trypanothione reductase were also done. Three compounds of 33 quinoxaline-7-carboxylate 1,4-di-N-oxide derivatives showed better anti-T. cruzi activity than nifurtimox and beznidazole; two compounds had better anti-leishmanial activity that amphotericin-B, and two compounds showed better activity against both parasites than reference drugs. Compounds M2, M7, M8 and E5, showed low cytotoxic activity on the host cell. The in silico studies suggest that compound M2 is a potential trypanothione reductase inhibitor. 相似文献
8.
de Gonzalo-Calvo D Fernández-García B de Luxán-Delgado B Rodríguez-González S García-Macia M Suárez FM Solano JJ Rodríguez-Colunga MJ Coto-Montes A 《Age (Dordrecht, Netherlands)》2012,34(3):761-771
The objective of the present study was to investigate the changes in a large panel of emergent geriatric biomarkers in long-term
trained elderly men to analyze the effects of long-term exercise on an aged population. We collected blood samples from two
groups of male volunteers older than 65 years who maintain a measure of functional independence: one group of sedentary subjects
without a history of regular physical activity and the other of subjects who have sustained training, starting during adulthood
(mean training time = 49 ± 8 years). We studied morbidity, polypharmacy, cellular and serological inflammatory parameters,
and endocrine mediators. After adjusting for confounding factors, we observed reduced medication intake per subject and lower
number of diseases per subject with statistical differences nearly significant in the long-term exercise group. We showed
that long-term training was associated with lower levels of white blood cell counts, neutrophil counts, interleukin-6, interleukin-10,
interleukin-1 receptor antagonist, and soluble TNF receptor-I. Furthermore, we noted an increase in the concentrations of
insulin-like growth factor-1 and dehydroepiandrosterone in the long-term training group. We concluded that long-term exercise
training from adulthood to old age is clearly associated with a healthy profile of emergent geriatric biomarkers. Long-term
training could improve the inflammatory–endocrine imbalance associated with disease, frailty, functional decline, and mortality
in elderly men. Our results point to the benefits of prolonged exercise from adulthood to old age. 相似文献
9.
10.
García-Reyna Benjamín Castillo-García Gilberto Daniel Barbosa-Camacho Francisco José Cervantes-Cardona Guillermo Alonso Cervantes-Pérez Enrique Torres-Mendoza Blanca Miriam Fuentes-Orozco Clotilde Pintor-Belmontes Kevin Josue Guzmán-Ramírez Bertha Georgina Bernal-Hernández Aldo González-Ojeda Alejandro Cervantes-Guevara Gabino 《International journal of mental health and addiction》2022,20(2):895-906
International Journal of Mental Health and Addiction - The presence of COVID-19 has had psychological consequences among health personnel; these include fear, anxiety, and depression. In the... 相似文献