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排序方式: 共有73条查询结果,搜索用时 109 毫秒
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Aggravation of experimental cutaneous leishmaniasis in mice by administration of interleukin 3 总被引:7,自引:0,他引:7
Z Y Feng J Louis V Kindler T Pedrazzini J F Eliason R Behin P Vassalli 《European journal of immunology》1988,18(8):1245-1251
Previous studies from our laboratory have shown that some in vitro maintained Leishmania major-specific L3T4+ T cells were capable of exacerbating cutaneous leishmaniasis after adoptive transfer to normal syngeneic mice. Results presented in this report show that these cells released substantial amounts of interleukin 3 (IL 3) and granulocyte-macrophage colony-stimulating factors after specific stimulation in vitro. In order to assess the involvement of such lymphokines in the exacerbation of cutaneous leishmaniasis by these L3T4+ T cells, the effect of the administration of important doses of IL 3 on the course of infection with L. major was investigated. The treatment of genetically susceptible BALB/c mice with IL 3 resulted in an enhancement of the size of lesions and favored the multiplication of parasites at anatomical sites distant from the primary lesion. Although IL 3 did not modify the development of lesions in genetically resistant CBA mice, this lymphokine promoted the growth of Leishmania in lymph node draining the lesion. Finally, the addition of IL 3 to macrophages parasitized in vitro enhanced the survival of intracellular Leishmania major. 相似文献
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Abdallah Fayssoil Lee S. Nguyen Tanya Stojkovic Helene Prigent Robert Carlier Helge Amthor Jean Bergounioux Justine Zini Sebastien Damez-Fontaine Karim Wahbi Pascal Laforet Guillaume Nicolas Anthony Behin Guillaume Bassez France Leturcq Rabah Ben Yaou Nicolas Mansencal Djillali Annane Frdric Lofaso David Orlikowski 《Muscle & nerve》2022,65(1):89-95
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This case report deals with a patient who presented with a rapidly progressive myelopathy due to an intracranial dural arteriovenous fistula with perimedullar drainage (type V). We shall discuss the main clinical and radiological features of this type of fistula and its treatment from a review of the published cases. 相似文献
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PURPOSE OF THIS REVIEW: To conduct a critical review of recent studies on the clinical and therapeutic aspects of multifocal motor neuropathy, and to analyse their implications for patient management. RECENT FINDINGS: Recent studies have contributed to defining the specific position of multifocal motor neuropathy within the spectrum of chronic immune-mediated polyneuropathies. One study compared features of this condition with multifocal acquired demyelinating sensory and motor neuropathy, while others have focused on pathological alterations at the site of conduction blocks. A further study described six new cases of multifocal acquired motor neuropathy, which should be considered as a variant of multifocal motor neuropathy. Several Cochrane reviews and review articles have shown evidence of the efficacy of intravenous immunoglobulins in the treatment of multifocal motor neuropathy. The issue of long-term intravenous immunoglobulins in multifocal motor neuropathy, however, has yielded controversial results. Two studies have shown progressive motor deterioration in most patients, correlated with electrophysiological signs indicative of axonal degeneration, while a third study found signs of sustained clinical and electrophysiological improvement after a mean follow up of 7.25 years. SUMMARY: Multifocal motor neuropathy is a distinct clinical entity that differs from chronic inflammatory demyelinating polyradiculoneuropathy and multifocal acquired demyelinating sensory and motor neuropathy, although they share some electrophysiological characteristics. Although the aetiology remains unsolved, frequent association with high-titer antibodies against ganglioside GM1, together with an often positive response to intravenous immunoglobulins further support an autoimmune mechanism. New therapeutic strategies are required, however, that focus on the effects and the costs of treatment over long-term follow up. 相似文献
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Combined benign odontogenic tumors: CT and MR findings and histomorphologic evaluation 总被引:1,自引:0,他引:1
Martin-Duverneuil N Roisin-Chausson MH Behin A Favre-Dauvergne E Chiras J 《AJNR. American journal of neuroradiology》2001,22(5):867-872
SUMMARY: Calcifying epithelial odontogenic tumors and calcifying odontogenic cysts are rare, benign odontogenic tumors. We report two cases of an exceptional combination of these tumors with either an ameloblastic fibroodontoma or an odontoma. 相似文献