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Therefore, the current study aimed to diagnose the genes associated in the pathogenesis of GBM. The differentially expressed genes (DEGs) were diagnosed using the limma software package. The ToppFun was used to perform pathway and Gene Ontology (GO) enrichment analysis of the DEGs. Protein-protein interaction (PPI) networks, extracted modules, miRNA-target genes regulatory network and miRNA-target genes regulatory network were used to obtain insight into the actions of DEGs. Survival analysis for DEGs carried out. A total of 701 DEGs, including 413 upregulated and 288 downregulated genes, were diagnosed between U1118MG cell line (PK 11195 treated with 1?h exposure) and U1118MG cell line (PK 11195 treated with 24?h exposure). The up-regulated genes were enriched in superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis, cell cycle, cell cycle process and chromosome. The down-regulated genes were enriched in folate transformations I, biosynthesis of amino acids, cellular amino acid metabolic process and vacuolar membrane. The current study screened the genes in PPI network, extracted modules, miRNA-target genes regulatory network and miRNA-target genes regulatory network with higher degrees as hub genes, which included MYC, TERF2IP, CDK1, EEF1G, TXNIP, SLC1A5, RGS4 and IER5L Survival suggested that low expressed NR4A2, SLC7?A5, CYR61 and ID1 in patients with GBM was linked with a positive prognosis for overall survival. In conclusion, the current study could improve our understanding of the molecular mechanisms in the progression of GBM, and these crucial as well as new molecular markers might be used as therapeutic targets for GBM. 相似文献
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Bhushan B. Kulkarni Shivaprakash V. Hiremath Suyamindra S. Kulkarni Umesh R. Hallikeri Basavaraj R. Patil Pramod B. Gai 《Journal of virological methods》2013
The identification of the etiology of breast cancer is a crucial research issue for the development of an effective preventive and treatment strategies. Researchers are exploring the possible involvement of Mouse Mammary Tumor Virus (MMTV) in causing human breast cancer. Hence, it becomes very important to use a consistent positive control agent in PCR amplification based detection of MMTV-Like Sequence (MMTV-LS) in human breast cancer for accurate and reproducible results. This study was done to investigate the feasibility of using genomic DNA of MCF-7 breast cancer cells to detect MMTV-LS using PCR amplification based detection. MMTV env and SAG gene located at the 3′ long terminal repeat (LTR) sequences were targeted for the PCR based detection. No amplification was observed in case of the genomic DNA of MCF-7 breast cancer cells. However, the 2.7 kb DNA fragment comprising MMTV env and SAG LTR sequences yielded the products of desired size. From these results it can be concluded that Genomic DNA of MCF-7 cell is not a suitable choice as positive control for PCR or RT-PCR based detection of MMTV-LS. It is also suggested that plasmids containing the cloned genes or sequences of MMTV be used as positive control for detection of MMTV-LS. 相似文献
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Younghee Kim Valeria Tarallo Nagaraj Kerur Tetsuhiro Yasuma Bradley D. Gelfand Ana Bastos-Carvalho Yoshio Hirano Reo Yasuma Takeshi Mizutani Benjamin J. Fowler Shengjian Li Hiroki Kaneko Sasha Bogdanovich Balamurali K. Ambati David R. Hinton William W. Hauswirth Razqallah Hakem Charles Wright Jayakrishna Ambati 《Proceedings of the National Academy of Sciences of the United States of America》2014,111(45):16082-16087
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Hearing-impaired children in the age range of 3-6 years, registered at the Rehabilitation Unit of Audiology and Speech Pathology, Department of ENT, A.I.I.M.S., New Delhi as the 'control group' of the project 'SAFA for the hearing-impaired', were studied for their articulatory ability. The findings are discussed in the frame work of Kosti? classification of the hearing-impaired which takes into consideration the degree of hearing impairment as well as the age of onset of loss. 相似文献
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