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1.
E C Taylor D Kuhnt C Shih S M Rinzel G B Grindey J Barredo M Jannatipour R G Moran 《Journal of medicinal chemistry》1992,35(23):4450-4454
N-[4-[2-(2-Amino-3,4-dihydro-4-oxo-7H-pyrrolo[2,3-d]pyrimidin-5- yl)ethyl]benzoyl]-L-glutamic acid (15), prepared in five steps from 2-pivaloyl-7-deazaguanine, has been found to be an antitumor agent with its primary site of action at thymidylate synthase rather than purine synthesis. This compound appears to be a promising candidate for clinical evaluation. 相似文献
2.
A phase I window,dose escalating and safety trial of metformin in combination with induction chemotherapy in relapsed refractory acute lymphoblastic leukemia: Metformin with induction chemotherapy of vincristine,dexamethasone, PEG‐asparaginase,and doxorubicin
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3.
All Patients With the T(11; 16)(q23; p13.3) That Involves MLL and CBP Have Treatment-Related Hematologic Disorders 总被引:14,自引:0,他引:14
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Background
Expression of folylpoly-γ-glutamate synthetase (FPGS) gene is two- to three-fold higher in B-precursor ALL (Bp- ALL) than in T-lineage ALL (T-ALL) and correlates with intracellular accumulation of methotrexate (MTX) polyglutamates and lymphoblast sensitivity to MTX. In this report, we investigated the molecular regulatory mechanisms directing FPGS gene expression in Bp-ALL and T-ALL cells. 相似文献6.
Adenylate kinase (AK) modulates the interconversion of adenine nucleotides (AMP + adenosine triphosphate----2 ADP). We evaluated the fifth kindred with hereditary erythrocyte (RBC) AK deficiency. The proband had chronic hemolytic anemia. Her RBC had undetectable AK activity when measured spectrophotometrically, whereas those of her parents had half-normal AK activity. AK electrophoresis showed only AK-1 in the parents. The activities of pyruvate kinase and phosphoribosylpyrophosphate synthetase were decreased given the young age of the proband's RBC. Despite the absence of spectrophotometric AK activity, the proband's RBC were able to incorporate 14C-adenine into 14C-adenine nucleotides at 50% of the rate expected for her young RBC population, suggesting the possibility of an alternative pathway for the formation of ADP from AMP. Normal hemolysate had AMP:guanosine triphosphate (GTP) phosphotransferase activity, which produced ADP at 8% to 9% of the rate of AK (6.8 +/- 0.8 IU/mL RBC). AMP:GTP phosphotransferase activity was not detectable in the proband's or parent's hemolysates. These additional biochemical defects in the AK-deficient RBC further support the concept that AK deficiency per se may not cause hemolytic anemia. We propose that defects occur in multiple phosphotransferases in the AK-deficient RBC and that these other biochemical defects may produce deleterious lesions that promote the shortened RBC survival in AK deficiency. 相似文献
7.
Management of paranasal sinus malignancy 总被引:1,自引:0,他引:1
Day TA Beas RA Schlosser RJ Woodworth BA Barredo J Sharma AK Gillespie MB 《Current treatment options in oncology》2005,6(1):3-18
Opinion statement Malignancies of the nasal cavity and paranasal sinuses represent a wide spectrum of histologies, tissues
of origin, and anatomic primary sites. The inherent difficulty in generalizing treatment approaches is obvious, given the
numerous variables associated with the broadly-based term, paranasal sinus malignancy (PNSCa). Nevertheless, the majority
of epithelial and salivary malignancies of this region (ie, squamous cell carcinoma, adenocarcinoma, adenoid cystic carcinoma, sinonasal undifferentiated carcinoma, and esthesioneuroblastoma)
require surgical intervention as part of any treatment regimen. Recent trends have broadened the indications for chemotherapeutic
and radiotherapeutic options in the management of advanced PNSCa. Nonepithelial malignancies, including the wide variety of
sarcomas arising in this region, most commonly require multimodality treatment including chemotherapy, radiation, and/or surgery
for definitive treatment. Moreover, the proximity of the nasal cavity and paranasal sinuses to structures including the orbit,
dura, brain, cranial nerves, and carotid arteries mandates careful radiologic and neurologic evaluations throughout the course
of the disease. Surgical advances now permit complex tumor removal and reconstruction surrounding these structures resulting
in functional and cosmetic improvements when compared to earlier techniques. However, additional clinical trials are necessary
to systematically evaluate the locoregional control, organ-preservation strategies, and survival related to the variety of
treatments currently available. 相似文献
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Kristien Peeters PhD Paulius Palaima MSc Ana L. Pelayo‐Negro MD Antonio García MD Elena Gallardo MD Rosario García‐Barredo MD Ligia Mateiu MD PhD Jonathan Baets MD PhD Björn Menten PhD Els De Vriendt BSc Peter De Jonghe MD PhD Vincent Timmerman PhD Jon Infante MD PhD José Berciano MD PhD Albena Jordanova PhD 《Annals of neurology》2016,80(6):823-833