全文获取类型
收费全文 | 679篇 |
免费 | 45篇 |
国内免费 | 21篇 |
专业分类
儿科学 | 18篇 |
妇产科学 | 6篇 |
基础医学 | 69篇 |
口腔科学 | 13篇 |
临床医学 | 56篇 |
内科学 | 156篇 |
皮肤病学 | 18篇 |
神经病学 | 9篇 |
特种医学 | 161篇 |
外科学 | 59篇 |
综合类 | 17篇 |
预防医学 | 28篇 |
眼科学 | 51篇 |
药学 | 32篇 |
中国医学 | 3篇 |
肿瘤学 | 49篇 |
出版年
2022年 | 5篇 |
2021年 | 10篇 |
2020年 | 4篇 |
2019年 | 5篇 |
2018年 | 6篇 |
2017年 | 16篇 |
2016年 | 12篇 |
2015年 | 4篇 |
2014年 | 19篇 |
2013年 | 20篇 |
2012年 | 26篇 |
2011年 | 23篇 |
2010年 | 29篇 |
2009年 | 22篇 |
2008年 | 10篇 |
2007年 | 28篇 |
2006年 | 19篇 |
2005年 | 26篇 |
2004年 | 19篇 |
2003年 | 15篇 |
2002年 | 16篇 |
2001年 | 12篇 |
2000年 | 16篇 |
1999年 | 15篇 |
1998年 | 27篇 |
1997年 | 17篇 |
1996年 | 13篇 |
1995年 | 19篇 |
1994年 | 17篇 |
1993年 | 16篇 |
1992年 | 13篇 |
1991年 | 11篇 |
1990年 | 18篇 |
1989年 | 26篇 |
1988年 | 22篇 |
1987年 | 21篇 |
1986年 | 17篇 |
1985年 | 21篇 |
1984年 | 6篇 |
1982年 | 7篇 |
1981年 | 8篇 |
1980年 | 7篇 |
1979年 | 7篇 |
1978年 | 9篇 |
1977年 | 13篇 |
1976年 | 9篇 |
1975年 | 8篇 |
1970年 | 4篇 |
1969年 | 12篇 |
1962年 | 3篇 |
排序方式: 共有745条查询结果,搜索用时 15 毫秒
1.
2.
Pseudomembranous colitis is not a rare complication of antibiotic therapy. 2000 surgical procedures with implantation of grafts in the aorto-iliac region were performed from 1974 through 1988; during this period 11 cases of CMP were observed. The Authors report their experience in regard to the various antibiotics administered. 相似文献
3.
4.
5.
C Masciocchi C D'Archivio A Barile E Fascetti S Di Giovanni B Beomonte Zobel M Gallucci R Passariello 《La Radiologia medica》1992,83(5):561-568
The authors retrospectively reviewed the MR examinations of 46 patients with clinical and laboratory findings of monoclonal gammopathies (MG). All cases had been submitted to radiographic examination which had shown skeletal involvement in 22 cases and osteoporosis in 11, with rupture of the vertebral body in 3 patients. Scintigraphy had been performed on all patients and CT on 12; 36 patients were subsequently submitted to follow-up (at 6, 12 and 24 months). MR examinations were performed with dedicated coils and standard sequences for the subjects with skeletal localizations on X-ray images. The extant cases, with no radiographic evidence of skeletal involvement, were submitted to MRI of the spine, skull and pelvis. In agreement with clinical and laboratory findings and with follow-up results (in 36 patients), MRI diagnosed MG with no skeletal involvement in 13 cases, osteoporosis in 8 (with rupture of the vertebral body in 2), asymptomatic non-progressive myeloma in 4, solitary myeloma in 3, and multiple myeloma in 18 cases. The good identification of bone marrow and its multiplanarity make MRI the method of choice in the study of patients with suspected or known gammopathies. If compared with other modalities, MRI is more sensitive and accurate in depicting the tumor, its size and relationship to periskeletal tissues, and its possible multifocality. Moreover, the technique has proven to be a valid tool during the follow-up, showing tumor response to therapy. 相似文献
6.
Perfluorochemicals as US contrast agents for tumor imaging and hepatosplenography: preliminary clinical results 总被引:3,自引:0,他引:3
Mattrey RF; Strich G; Shelton RE; Gosink BB; Leopold GR; Lee T; Forsythe J 《Radiology》1987,163(2):339-343
In animals, perfluorochemicals (PFCs) are effective ultrasound (US) contrast agents that produce hepatic, splenic, and tumor enhancement. The use of Fluosol-DA 20%, an emulsion of perfluorodecalin and perfluorotripropylamine, was studied in nine non-critically ill patients with cancer who had liver lesions. US studies without Fluosol were compared with studies obtained 24, 48, and 72 hours after Fluosol infusion. Vital signs and extensive laboratory analyses are performed before and after Fluosol infusion. Liver metastases from colonic, pancreatic, and gastric carcinoma exhibited rim or diffuse enhancement after a Fluosol dose of 1.6 g/kg or greater. Fluosol produced echogenic enhancement of the liver and spleen relative to kidney at a dose of 2.4 g/kg, allowing the detection of nonenhancing lesions. In addition, Fluosol at a dose of 1.6 g/kg or greater allowed detection of lesions not seen before contrast medium was administered in three of the seven patients studied. There was a mild increase in the level of serum glutamic oxaloacetic transaminase in two patients, one given 2.4 and the other 3.2 g/kg of Fluosol. Mild and transient allergic reactions without change in vital signs were experienced by two patients. 相似文献
7.
Lumbar disk herniation: MR imaging assessment of natural history in patients treated without surgery. 总被引:7,自引:0,他引:7
The aim of this study was to evaluate the evolution of lumbar disk herniation in patients treated without surgery. Sixty-nine patients with a lumbar disk herniation proved at magnetic resonance (MR) imaging underwent a follow-up MR imaging study. The disk herniations evaluated during both MR imaging examinations were measured and classified into four categories according to the change in size that occurred. The patients were also divided into three clinical classes on the basis of the clinical outcome. Sixty-three percent of the patients showed a reduction of disk herniation of more than 30% (48% had a reduction of more than 70%), while only 8% demonstrated worsening of the clinical picture. These findings suggest that lumbar disk herniation may be primarily a medical (nonsurgical) disease and that MR imaging could play an important role in management of and research into the disorder. 相似文献
8.
9.
Jonathan H. Marsh Willi Kreis Barbara Barile Silvia Akerman Philip Schulman Steven L. Allen Linda C. DeMarco Michael W. Schuster Daniel R. Budman 《Cancer chemotherapy and pharmacology》1993,31(6):481-484
Summary Eight patients, of whom four had acute myeloid leukemia (AML) and four had chronic myeloid leukemia (CML) blast crisis, were treated with a combination of cytosine arabinoside (ARA-C: 1,600 mg/m2 in three patients, 1,200 mg/m2 in five patients), tetrahydrouridine (THU: 2,800 mg/m2 in two patients, 2,646 mg/m2 in one patient, 2,100 mg/m2 in five patients), and carboplatin (900 mg/m2 in four patients, 720 mg/m2 in one patient, 450 mg/m2 in three patients). As a result of this treatment, five of the eight patients became aplastic. Two of the four patients with CML blast crisis reverted to the chronic phase and two of the four patients with acute nonlymphocytic leukemia (ANLL) attained a remission (one partial remission and one complete remission). The major toxicities included myelosuppression, unacceptable hepatotoxicity, and diarrhea. Pharmacokinetics studies revealed that the addition of carboplatin did not significantly change the disposition of ARA-C. ARA-C levels were not significantly changed in comparison with those obtained in a prior study of ARA-C with THU (ARA-C plasma levels at 3 h, 2630±1170 ng/ml).Supported by the Don Monti Memorial Research Foundation 相似文献
10.
Pre-eclampsia, one of the most significant health problems inhuman pregnancy, complicates 6-7% of all gestations and is theleading cause of fetal growth retardation, infant morbidityand mortality, premature birth and maternal death. Recent researchimplicates free radicals in the pathophysiology of pre-eclampsia.This review covers the biochemistry of nitric oxide (NO) andpossible interactions with other free radicals. Studies in therat show that pregnancy is associated with enhanced productionand responsiveness to NO in both reproductive tissues and bloodvessels. Rats infused with NG-nitro-L-arginine methyl ester(L-NAME, a NO synthase inhibitor) have been used as an animalmodel of pre-eclampsia, and the effects of steroid hormoneson blood pressure in this model have been tested. Results suggestthat pre-eclampsia may be a state of NO deficiency. However,in humans there seem to be contradictions regarding the involvementof NO in maternal adaptation to pregnancy. It is suggested thatNO may be one of several systems that act in concert to maintaina symbiotic relationship between mother and fetus. However,the input of each system may be genetically determined. 相似文献