全文获取类型
收费全文 | 2569篇 |
免费 | 206篇 |
国内免费 | 15篇 |
专业分类
耳鼻咽喉 | 45篇 |
儿科学 | 96篇 |
妇产科学 | 124篇 |
基础医学 | 265篇 |
口腔科学 | 110篇 |
临床医学 | 211篇 |
内科学 | 598篇 |
皮肤病学 | 42篇 |
神经病学 | 204篇 |
特种医学 | 197篇 |
外科学 | 267篇 |
综合类 | 93篇 |
一般理论 | 1篇 |
预防医学 | 135篇 |
眼科学 | 39篇 |
药学 | 109篇 |
1篇 | |
中国医学 | 4篇 |
肿瘤学 | 249篇 |
出版年
2023年 | 9篇 |
2022年 | 13篇 |
2021年 | 55篇 |
2020年 | 32篇 |
2019年 | 58篇 |
2018年 | 102篇 |
2017年 | 74篇 |
2016年 | 84篇 |
2015年 | 76篇 |
2014年 | 106篇 |
2013年 | 99篇 |
2012年 | 143篇 |
2011年 | 122篇 |
2010年 | 115篇 |
2009年 | 79篇 |
2008年 | 102篇 |
2007年 | 109篇 |
2006年 | 147篇 |
2005年 | 95篇 |
2004年 | 102篇 |
2003年 | 103篇 |
2002年 | 87篇 |
2001年 | 59篇 |
2000年 | 52篇 |
1999年 | 56篇 |
1998年 | 42篇 |
1997年 | 53篇 |
1996年 | 55篇 |
1995年 | 44篇 |
1994年 | 41篇 |
1993年 | 38篇 |
1992年 | 31篇 |
1991年 | 33篇 |
1990年 | 40篇 |
1989年 | 36篇 |
1988年 | 26篇 |
1987年 | 20篇 |
1986年 | 17篇 |
1985年 | 22篇 |
1984年 | 18篇 |
1983年 | 16篇 |
1982年 | 22篇 |
1981年 | 16篇 |
1980年 | 16篇 |
1979年 | 12篇 |
1978年 | 13篇 |
1977年 | 10篇 |
1976年 | 18篇 |
1975年 | 12篇 |
1973年 | 8篇 |
排序方式: 共有2790条查询结果,搜索用时 31 毫秒
1.
2.
3.
gnes Rimanczy Romana lamberov Noffar Bar Ilona Vathy 《International journal of developmental neuroscience》2006,24(4):241-248
Our previous work demonstrated that the hormone response to stress and the negative feedback inhibition to these hormones are sex-dependently altered by prenatal morphine exposure in adult rats. An alteration in the glucocorticoid negative feedback inhibition is mediated by glucocorticoid receptors (GR) that are distributed throughout the brain, and mineralocorticoid receptors (MR) localized mainly in the hippocampus and involved in a tonic influence of brain functions. Therefore, the present study examined the binding characteristics of MR and GR in young adult male and female rats exposed prenatally (E11-E18) to morphine (10 mg/kg/2 x /day), saline or no treatment at all (controls). At 60-90 days of age, animals were adrenalectomized (ADX) 24 h prior to decapitation. The hippocampus and hypothalamus were dissected for saturation binding assays. The data demonstrate that prenatal stress due to maternal saline injections up-regulates MR and GR binding in the hippocampus of adult male rats and this effect is prevented by prenatal morphine exposure. There is no effect of prenatal morphine exposure on GR binding in the hypothalamus of males. In female rats, prenatal morphine exposure does not affect the binding of MR and GR in the hippocampus or GR in the hypothalamus relative to controls; however, they are affected by ovarian hormone fluctuation. Moreover, prenatal stress decreases MR binding in the hippocampus of diestrous females and GR binding in the hypothalamus of estrous females. Both decreases are prevented by prenatal morphine exposure. Thus, the present study demonstrates that: (1) prenatal stress due to maternal saline injections alters MR and GR binding of adult male and female rats and is prevented by prenatal morphine exposure; (2) the MR and GR binding in adult female rats are affected by ovarian hormone fluctuations. 相似文献
4.
A clinical trial on the prevention of catheter-related sepsis using a new hub model. 总被引:8,自引:0,他引:8
下载免费PDF全文
![点击此处可从《Annals of surgery》网站下载免费的PDF全文](/ch/ext_images/free.gif)
M Segura F Alvarez-Lerma J M Tellado J Jiménez-Ferreres L Oms J Rello T Baró R Sánchez A Morera D Mariscal J Marrugat A Sitges-Serra 《Annals of surgery》1996,223(4):363-369
BACKGROUND: Catheter hub contamination is being increasingly recognized as a source of catheter-related sepsis. The authors have investigated the efficacy of a new hub design in preventing endoluminal catheter contamination and catheter-related sepsis arising at the hub. METHODS: Adult surgical and intensive care patients requiring a subclavian catheter for at least 1 week were randomly assigned to receive catheters with standard connectors (control group, n=73) or equipped with a new hub model (new hub group, n=78). Skin, catheter tip, and hub cultures were performed at the time the catheter was withdrawn because therapy was terminated or because of suspicion of sepsis, in which case peripheral blood cultures were taken. RESULTS: Of the 151 patients included, 15 (10%) developed catheter-related sepsis. Catheters were more often withdrawn because suspicion of infection in the control group (42 vs. 19%, p<0.005). Catheter sepsis rate was higher in the control group (16 vs. 4%, p<0.01) because of the low rate of catheter sepsis arising at the hub observed in the new hub group (1 vs. 11%, p<0.01). The prevalence of culture-positive catheter hubs without associated bacteremia (colonization) was higher in the control group (18 vs. 5%, P<0.03). CONCLUSIONS: A new catheter hub has proved to be useful in preventing endoluminal bacterial colonization and catheter-related sepsis in subclavian lines inserted for a mean of 2 weeks. 相似文献
5.
6.
7.
De Leo V; Morgante G; Lanzetta D; D'Antona D; Bertieri RS 《Human reproduction (Oxford, England)》1997,12(2):357-360
We report the results of administration of danazol after suspension of
gonadotrophin-releasing hormone analogue (GnRHa) therapy for uterine
myomas. A total of 21 women with uterine myomas was treated with 100 mg
danazol for 6 months after GnRHa therapy. Uterine volume and endocrine
status were monitored monthly by ultrasound and assay of plasma
gonadotrophins, oestradiol and progesterone. The results show a rebound of
uterine volume about 30% less than in controls at the end of danazol
therapy. Menstrual cyclicity returned after 65 +/- 3 days in 16 subjects
and five patients remained amenorrhoeic. Hormone assays confirmed renewed
ovarian function in the women whose menstrual periods returned. Bone
mineral content was substantially reduced during GnRHa treatment but
improved significantly during danazol therapy even in the women who
remained amenorrhoeic. These results show the utility of danazol in
prolonging the therapeutic effects of GnRHa. The mechanism by which danazol
inhibits rebound of uterine volume may be due to its antiprogesterone
effects on uterine myomas.
相似文献
8.
9.
10.