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排序方式: 共有568条查询结果,搜索用时 15 毫秒
1.
H W Snyder J H Bertram D H Henry D D Kiprov W B Benny A Mittelman G L Messerschmidt S K Cochran W Perkins J P Balint 《AIDS (London, England)》1991,5(10):1257-1260
Thirty-seven HIV-infected homosexual men with thrombocytopenia (less than 100 x 10(9)/l) received protein A immunoadsorption treatments to remove platelet-sensitizing immunoglobulin (Ig) G and circulating immune complexes (CIC) from plasma. Patients received an average of six treatments each, consisting of 250 ml plasma over a 3-week period. Clinical improvement in hemorrhagic symptoms associated with substantial increase in platelet counts was achieved in 18 patients. These responses were maintained over a median follow-up period of more than 7 months in 14 evaluable patients who were not lost to follow-up (three patients relapsed in 2 weeks and one received another therapy). Generally, moderate transient treatment-related side-effects included fever, musculoskeletal pain, chills and nausea. A transient serum sickness-like reaction was observed in seven patients, leading to termination of treatment in two. Clinical responses were associated with significant decreases in levels of platelet-sensitizing Ig, including CIC. Stimulation of broadly cross-reactive anti-antigen-binding fragment [F(ab)2], antibodies contributed to these responses. Protein A immunoadsorption is an effective alternative treatment for HIV-associated thrombocytopenia. 相似文献
2.
Circannual variation in lymphocyte subsets, revisited 总被引:2,自引:0,他引:2
BACKGROUND: Circadian and circannual variations in lymphocyte subsets, especially CD8+ T-lymphocytes, have been reported. This study focuses on CD4+ T-lymphocyte seasonal variation over a 6-year 8-month period. STUDY DESIGN AND METHODS: Lymphocyte subsets were quantitated monthly for four healthy individuals from 1986 through 1992 as part of a flow cytometry quality-control program. RESULTS: In general, there were no significant seasonal changes in the total number of white cells or in total lymphocyte counts. The absolute numbers of CD4+ T-lymphocytes were lowest in summer when the CD8+ T-lymphocytes were highest. Mean CD4+ T-lymphocyte counts were 846, 967, 618, and 695 per microL for Subjects 1 through 4, respectively, in winter and 432, 670, 355, and 766 per microL, respectively, in summer. Two healthy subjects had CD4+ T-lymphocyte counts lower than 300 per microL on one or more occasions during the study period. In three of the four subjects, the percentage of B-lymphocytes in winter was almost double that in summer. In one of the four subjects, no circannual rhythm was observed in these lymphocyte subpopulations. CONCLUSION: The seasonal variation in CD4+ T- lymphocyte counts demonstrated in three healthy individuals over almost 7 years is again of interest in light of renewed consideration of using surrogate tests, such as CD4+ T-lymphocyte counts, to screen for AIDS- like diseases that may be in the blood supply. 相似文献
3.
G. A. Balint 《Bulletin of the World Health Organization》1998,76(2):207-212
Doctors need to be well informed about differences in the presentation of certain diseases in tropical and temperate climates. In this article the characteristics of some gastrointestinal diseases, as they recur in sub-Saharan Africa, are briefly reviewed. Diseases of the stomach--including ulcertaion and cancer--are uncommon in Africa, although duodenal ulcer is common all over the tropics. In contrast, colorectal cancer is an extremely rare illness in sub-Saharan Africa, while hepatocellular carcinoma is much commoner than in Europe or North America and the very high incidence of this tumour in tropical countries is cause for concern. 相似文献
4.
The family history in family practice: a questionnaire study 总被引:9,自引:7,他引:2
OBJECTIVES: Our aims were to investigate family medical history taking in
general practice, and to evaluate the value attached to the family medical
history as an aid to decision making in general practice. METHOD: A postal
questionnaire survey was conducted among all 291 GPs working within the
Calderdale and Kirklees Health Authority area. Each questionnaire was
followed by a reminder. The main outcome measures were answers to questions
on routine and opportunistic family history taking and a question about
transmitting knowledge about genetic risk to other members of the family.
Questions were also posed about the value attached to the family medical
history as an aid to decision making. RESULTS: A total of 193 GPs returned
the questionnaire (response rate 66.3%). On registration, 94.3% of GPs
indicated that enquiries were made about a family history of coronary heart
disease. Breast and colorectal cancer were specifically asked about by
48.4% and 30.7% of GPs, respectively. One-fifth of respondents indicated
that they asked a general question about family medical history. A little
over one-quarter of respondents indicated that they made opportunistic
enquiries about the family history or suggested that the patient should
inform other members of the family about possible risks. In the scenarios
highlighted in this study, the majority of respondents felt that the family
medical history had value as an aid to decision making. This was
particularly the case for checking a patient's cholesterol (92.1%) and for
initiating referrals in younger patients with possible cancer-related
symptoms (three-quarters of respondents). CONCLUSION: GPs value the family
medical history as an aid to decision making. Unfortunately, apart from
enquiries about coronary heart disease, routine or opportunistic family
history taking is not occurring in practice. Mechanisms need to be sought
to extract information from the family medical history so that it can be
more effectively used by GPs.
相似文献
5.
The occurrence of Chlamydia trachomatis in the semen of men participating in an IVF programme 总被引:1,自引:0,他引:1
Nagy Balint; Corradi Gyula; Vajda Zoltan; Gimes RezsO; Csomor Sandor 《Human reproduction (Oxford, England)》1989,4(1):54-56
Chlamydia trachomatis is one of the most common causative agentsof sexually transmitted diseases. The authors studied the occurrenceof C.trachomatis in the semen of 184 asymptomatic men participatingin the IVF programme. Twenty-six (14.1%) of the 184 tested werepositive for C.trachomatis, these patients and their wives receivingdoxycycline capsules twice, 100 mg on the first day and 100mg/day for the following 13 days. This treatment was effectivein 88.5% of the cases and in the rest, treatment continued witherithromycin 250 mg four times/day for 2 weeks. The authorscompared the semen parameters (cell count, motility, morphology,bovine mucus penetration and hypo-osmotic swelling test) inthe infected and non-infected groups and observed no significantdifference between these two groups 相似文献
6.
Using a specific radioimmunoassay technique it seems that Prostacyclin (PG-I2) has a strong effect on the cyclic nucleotide content of the rat gastric (fundic) mucosa. 1 min after an intragastric application of 100 g/kg PG-I2 the cAMP-content and in the 5th min the cGMP-content showed a highly significant decrease. It seems that the basic mechanism of action of PG-I2 is a typical hit and run effect, acting on the intracellular second messenger system. 相似文献
7.
Balint Nagy Erno Toth-Pal Csaba Papp Zoltan Ban Zoltan Papp 《Fetal and pediatric pathology》1998,18(3):213-219
Cystic fibrosis (CF) is the most common autosomal recessive disorder in Caucasians. The most frequent mutation associated with cystic fibrosis has been identified as the 3 bp deletion Delta F 508. While existing polymerase chain reactions (PCR) (allele specific amplification) used to screen for CF are both sensitive and specific, we tested the prenatal application of fluorescent polymerase chain reaction and subsequent DNA fragment analysis that appears to be fast and sensitive. DNA samples (n=146) isolated from amniotic fluid (n=108), chorion villus biopsies (n=6), and human peripheral blood (n=32) were analyzed for the presence of Delta F 508 using the fluorescent method. Of these, 10 carriers of Delta F 508 mutation were detected. We achieved the same results with conventional PCR and fluorescent PCR. 相似文献
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