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Six cases were examined to review the important anaesthetic implications of Larsen's syndrome. Potential problems arising in these patients are highlighted and emphasis placed on cervical spine and airway/respiratory management. 相似文献
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Lauren L. O'Mahoney PhD Patrick J. Highton PhD Laura Kudlek MSc Jessica Morgan BA Rosie Lynch BA Ella Schofield BMBCh Nayanika Sreejith BA Ajay Kapur BMBCh Afolarin Otunla BA Sven Kerneis BMBCh Olivia James BA Karen Rees PhD Ffion Curtis PhD Kamlesh Khunti FMedSci Jamie Hartmann-Boyce DPhil 《Diabetes, obesity & metabolism》2022,24(9):1850-1860
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Christopher Sainsbury MD Jingya Wang PhD Krishna Gokhale MSc Dionisio Acosta-Mena PhD Samir Dhalla MRPharmS Nathan Byne Joht Singh Chandan PhD Astha Anand BMBCh Jennifer Cooper MBBCh Kelvin Okoth MPH Anuradhaa Subramanian MSc Mansoor N. Bangash PhD Thomas Taverner PhD Wasim Hanif PhD Sandip Ghosh FRCP Parth Narendran PhD Kar K. Cheng PhD Tom Marshall PhD Georgios Gkoutos PhD Konstantinos Toulis PhD Neil Thomas PhD Abd Tahrani PhD Nicola J. Adderley PhD Shamil Haroon PhD Krishnarajah Nirantharakumar MD 《Diabetes, obesity & metabolism》2021,23(1):263-269
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Arif A. Khokhar BMBCh Alessandra Laricchia MD Francesco Ponticelli MD Won-Keun Kim MD Francesco Gallo Damiano Regazzoli MD Marco Toselli MD Alessandro Sticchi MD Rossella Ruggiero MD Alberto Cereda MD Adriana Zlahoda-Huzior MD Andrea Fisicaro MD Ilja Gardi MD Antonio Mangieri MD Bernhard Reimers MD Dariusz Dudek MD Antonio Colombo MD Francesco Giannini MD 《Catheterization and cardiovascular interventions》2021,98(3):595-604
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Ellen StC. Tullo MBBS MA John Spencer MBChB Louise Allan MA BMBCh PhD 《Journal of the American Geriatrics Society》2010,58(10):1987-1993
It is unclear whether geriatrics‐specific educational interventions lead to improvement in students' knowledge, skills, and attitudes and whether successful interventions possess any consistent features. This review examines the effect of educational interventions on undergraduate knowledge, skills, and attitudes in geriatric medicine and concludes that a wide range of innovative designs have the potential to improve each of these parameters, although evidence of interventions that improve student skills is lacking, and further research is necessary to confirm the efficacy of specific teaching strategies in geriatrics. 相似文献
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For many chronic diseases, the influence of genetics is complex and phenotypes do not conform to simple Mendelian patterns of inheritance. Discussed here are two types of genetic influences on healthy aging. The first involves variation in the gene sequence itself and how this may influence disease susceptibility, progression, and severity, interacting with other recognized risk factors. The second involves epigenetic regulatory mechanisms that may potentially provide insight into how environmental influences affect the expressed genome, thus improving our understanding of the genetic mechanisms underlying multifactorial diseases. The interleukin-1 family of cytokines can be used to illustrate how genetic sequence variation may affect such diseases. This cytokine family plays a key role in mediating inflammation, which is now understood to be a central component of a growing number of chronic diseases. Recent work has revealed many sequence variations in the regulatory DNA of genes encoding important members of the interleukin-1 family, and these variations are associated with differential effects on the inflammatory response. The interactions of environmental factors with both DNA sequence variations and epigenetic modifications are likely to determine the phenotypes of multifactorial diseases of aging as well as the phenotype of healthy aging. 相似文献
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