全文获取类型
收费全文 | 118篇 |
免费 | 0篇 |
专业分类
耳鼻咽喉 | 9篇 |
儿科学 | 4篇 |
妇产科学 | 5篇 |
基础医学 | 6篇 |
口腔科学 | 1篇 |
临床医学 | 8篇 |
内科学 | 26篇 |
皮肤病学 | 3篇 |
神经病学 | 3篇 |
外科学 | 33篇 |
综合类 | 1篇 |
预防医学 | 5篇 |
药学 | 14篇 |
出版年
2015年 | 2篇 |
2014年 | 1篇 |
2013年 | 4篇 |
2012年 | 1篇 |
2011年 | 1篇 |
2010年 | 1篇 |
2009年 | 3篇 |
2007年 | 1篇 |
2002年 | 1篇 |
1997年 | 5篇 |
1996年 | 3篇 |
1995年 | 2篇 |
1994年 | 2篇 |
1993年 | 4篇 |
1992年 | 3篇 |
1991年 | 1篇 |
1990年 | 2篇 |
1989年 | 3篇 |
1988年 | 2篇 |
1987年 | 1篇 |
1983年 | 3篇 |
1982年 | 1篇 |
1981年 | 2篇 |
1979年 | 3篇 |
1975年 | 1篇 |
1971年 | 1篇 |
1966年 | 2篇 |
1963年 | 1篇 |
1959年 | 1篇 |
1958年 | 14篇 |
1957年 | 12篇 |
1956年 | 17篇 |
1955年 | 6篇 |
1954年 | 10篇 |
1949年 | 1篇 |
排序方式: 共有118条查询结果,搜索用时 31 毫秒
1.
2.
C. NAPOLI A. LIGUORI P. SORICE A. DI BENEDETTO S. CIAFRE T. POSCA N. DI IESO F. P. D'ARMIENTO 《Journal of internal medicine》1996,240(6):389-394
Background. Arterial hypertension is a significant risk factor for the high rate of cardiovascular disease in chronic uraemic (CU) patients. Any role that hypertension may play in CU patient outcomes assumes added significance. The elevation of some hormonal factors in early clinical stage could represent a valuable marker of cardiac disease in CU. Aim. This study first investigated the role of several hormones on cardiac diastolic properties in CU patients. Moreover, the study investigated the association of hypertension with both diastolic function and release of vasoactive hormones in CU patients. Results. We have reported that the early impairment of diastolic function is correlated with the elevation of both circulating plasma atrial natriuretic factor and endothelin-1 (ET-1) in hypertensive CU patients. Since the effect of ET-1 on diastolic function is still poorly understood, we have investigated also this issue. In eight additional patients with reduced E/A ratio, but without uraemia, hypertension or chronic heart failure, we have showed a high inverse correlation between the values of E/A ratio and ET-1 plasma concentrations. Conclusions. These results strongly suggest that the elevation in ET-1 levels was correlated with diastolic dysfunction in man. This phenomenon may have important pathophysiological implications suggesting the possibility of an early therapeutic approach in these patients. 相似文献
3.
HARRISON RAYMOND D; MARINO DALE J; CONAWAY C. CLIFFORD; RUBIN LIONEL F; GANDY JAY 《Toxicological sciences》1989,12(3):491-507
Chronic Morpholine Exposure of Rats. HARBISON, R. D., MARINO,D. J., CONAWAY, C. C., RUBIN, L. F., AND GANDY, J. (1989). FundamAppl. Toxicol. 12,491507. The chronic toxicity and carcinogenicpotential of morpholine were evaluated in 60 Sprague-Dawleyrats/sex/group receiving morpholine at mean inhalation exposureconcentrations of 0, 10, 50 and 150 ppm for 6 hr/day, 5 days/week,for 104 weeks. Survival, body weight gains, organ weights, hematology,and clinical chemistries were normal in exposed groups and comparableto those of the control animals. The incidences of palpabletissue masses and of histologically confirmed neoplasia werecomparable among all groups, including the control groups, andwere typical of the strain and age of the rats tested. In-lifeclinical examinations revealed increased incidences of irritationaround the eyes and nares, chromadacryorrhea, and urine stainson the fur, predominately in high-dose animals. Morpholine exposurewas associated with corneal irritation seen by ophthalmoscopicexamination and confirmed microscopically as keratitis limitedto the highest exposure group. Irritation of the maxillary andnasoturbinates as indicated by infiltration of neutrophils,focal squamous metaplasia of the turbinate epithelium, and necrosisof the turbinate bone was observed in high-dose animals. Therefore,chronic exposure of rats to morpholine for 2 years at concentrationsof 150 ppm or less revealed no carcinogenic potential or chronicsystemic toxicity. Consistent with its known irritating properties,morpholine produced only local irritation, which was limitedalmost exclusively to high-dose animals. 相似文献
4.
CORNELIO UDERZO MARIA GRAZIA VALSECCHI ADRIANA BALDUZZI GIORGIO DINI ROBERTO MINIERO FRANCO LOCATELLI ROBERTO RONDELLI ANDREA PESSION WILLIAM ARCESE ANDREA BACIGALUPO PAOLA POLCHI MARINO ANDOLINA CHIARA MESSINA VALENTINO CONTER MAURIZIO ARICÓ STEFANIA GALIMBERTI & GIUSEPPE MASERA 《British journal of haematology》1997,96(2):387-394
We compared the outcome of children with high-risk acute lymphoblastic leukaemia (HR-ALL) in first complete remission (first CR) treated with chemotherapy (CHEMO) or with allogeneic bone marrow transplantation (BMT) in a multicentre study. All children treated by the Italian Paediatric Haematology Oncology Association for HR-ALL in first CR between 1986 and 1994 were eligible for the study. 30 children were given BMT at a median of 4 months from first CR, with preparative regimens including total-body irradiation ( n =25/30). 130 matched controls for BMT patients were identified among 397 HR-ALL CHEMO patients. Matching on main prognostic factors and duration of first CR was adopted to control the selection and time-to-transplant biases. The comparative analysis was based on the results of a stratified Cox model. The estimated hazard ratios of BMT versus CHEMO at 6 months, 1 year and 2 years after CR were 1.38 (CI 0.59–3.24), 0.69 (CI 0.27–1.77) and 0.35 (CI 0.06–1{\raise 5mu ..91), with an overall non-significant difference between the two groups ( P = 0.34). With a median follow-up of 4 years, the disease-free survival was 58.5% (SE 9.3) in the BMT group and 47.7% (SE 4.8) in the CHEMO group, at 4 years from CR. Non-leukaemic death occurred in 4% of CHEMO and 10% of BMT patients. In the BMT group the estimated cumulative incidence of relapse at 1.5 years from CR was 31.5% (SE 8.8) and did not change thereafter, whereas in the CHEMO group the corresponding figure was 29.2% (SE 4.1) and the incidence continued to increase thereafter (48.2% (SE 4.8) at 4 years from CR). The results of this study suggest that, with respect to the CHEMO group, the higher risk of early failure in the BMT group is outweighed by the lower risk of relapse after 1 year. Results prompt the need for a prospective study, in order to demonstrate the likely advantage of BMT in HR childhood ALL in first CR. 相似文献
5.
6.
GIUSEPPE CRITELLI M.D. CESARE GRECO M.D. MARIA AMBROSINI M.D. RICCARDO SINATRA M.D. BENEDETTO MARINO M.D. ATTILIO REALE M.D. 《Journal of cardiovascular electrophysiology》1990,1(4):330-333
The occurrence of inappropriate discharge from an implanted cardioverter-defibrillator is reported. The device was triggered by an episode of induced nonsustained ventricular tachycardia, and the shock was delivered 10 sec after spontaneous termination of the arrhythmia.
This observation demonstrates that unexpected discharges from an implanted cardiaverter/defibrillator can occur while the patient is asymptomatic. In order to avoid such an adverse effect, improvement of the detection system of the device is advisable. 相似文献
This observation demonstrates that unexpected discharges from an implanted cardiaverter/defibrillator can occur while the patient is asymptomatic. In order to avoid such an adverse effect, improvement of the detection system of the device is advisable. 相似文献
7.
EEG AND MEMORY EFFECTS OF LOW-DOSE INFUSIONS OF PROPOFOL 总被引:3,自引:0,他引:3
VESELIS R. A.; REINSEL R. A.; WRONSKI M.; MARINO P.; TONG W. P.; BEDFORD R. F. 《British journal of anaesthesia》1992,69(3):246-254
The purpose of this study was to identify EEG changes associatedwith low-dose propofol infusion producing only sedative effects,and to describe the memory effects of low-dose propofol infusion.Ten healthy volunteers underwent EEG monitoring (at Fz, Cz,Pz and Oz electrode sites) before, during and after propofol0.5mg kg1 i.v. bolus and 75 fig kg1 min1as an infusion. Mean serum concentration of propofol duringinfusion was 0.86 (SD 0.14) µg ml1. The EEG changedsignificantly during infusion, with increased power in the beta,(1520 Hz). beta2 (20.530 Hz) and delta (13.5Hz) frequencies. Beta1 and beta2 power changes were most markedat the Fz and Cz electrodes. Subjects were sedated, but ableto complete cognitive tasks. Visual analogue scales of attentionand sleepiness were obtained throughout the study and demonstrateda sedative effect during propofol infusion, but were not a significantfactor in memory performance or EEG changes. A verbal learningtask (Rey Auditory-Verbal Learning Task) administered before,during and after infusion showed a marked reduction in short-termmemory capacity and dramatically impaired free recall and recognitionduring infusion. Nine of 10 subjects had partial amnesia forcomplex visual scenes presented during infusion, recalling lessthan 50% of the material. Stronger cueing was required to retrieveinformation presented during propofol infusion, with an increasein mean retrieval time from 95.4 (41.2) s to 426.8 (83.1) s.EEG and memory effects resolved quickly after the end of infusion.We conclude that anterior, high frequency EEG activity increasessignificantly during low-dose propofol infusion and that propofolproduces significant memory impairment which has characteristicsof true amnesia, concurrent with changes in beta, power in theEEG. The fact that low-dose propofol produces significant changesin both cognitive and EEG measures warrants further investigationinto the utility of the EEG power spectrum as a useful monitorof amnesia during conscious sedation with propofol.
相似文献
8.
MARK T. MARINO MICHAEL R. URQUHART MICHELLE L. SPERRY JURGEN VON BREDOW LARRY D. BROWN EMIL LIN THOMAS G. BREWER 《The Journal of pharmacy and pharmacology》1997,49(3):282-287
Methaemoglobin, the oxidized form of haemoglobin, can be formed by a variety of agents, most of which act to oxidize haemoglobin directly or indirectly. Cyanide has a higher affinity for methaemoglobin than for mitochondrial cytochromes, making methaemoglobin formation a basis for the treatment of cyanide poisoning. We used the beagle dog model to investigate the relationship between drug concentration and methaemoglobin levels for two candidate anti-cyanide compounds. The compounds studied were the aminophenones p-aminopropiophenone (PAPP) and p-aminoheptylphenone (PAHP). Both PAPP and PAHP were given as intravenous boluses and as two different oral formulations. The kinetics of both compounds appeared to follow a three-compartment open model for intravenous bolus administration and a two-compartment open model for oral administration. The first distribution phase seen with the intravenous administration was obscured by the absorption phase during oral administration. Bioavailability for all formulations varied between 20 and 47%. For both compounds there was a delay between the appearance of drug in the plasma and the appearance of methaemoglobin (counter-clockwise hysteresis) which is suggestive of an active metabolite causing methaemoglobin formation. The pharmacodynamics were fit with an effect-compartment kinetic-dynamic model linked to a sigmoid Emax pharmacodynamic model. Maximum amounts of methaemoglobin occurred between 2 and 4 h for PAHP and between 1 and 3 h for PAPP. When administered intravenously estimates of EC50 were lower than the estimates of EC50 from oral administration for both compounds. This might be because of oral first-pass inactivation or a ‘first-pass’ activation through the lungs contributing to the formation of an active metabolite. The phenones as a class appear to have the drug cleared and methaemoglobin return to near baseline within 12 h. Both compounds seem to produce sufficient methaemoglobin to treat acute cyanide poisoning and to serve as prophylactic agents against acute cyanide poisoning in a military setting. 相似文献
9.
FRANCA MARINO FILOMENA CRETA FABRIZIO DE PONTI CRISTINA GIARONI SERGIO LECCHINI GIAN MARIO FRIGO 《The Journal of pharmacy and pharmacology》1993,45(7):668-670
Abstract— We have studied the effects of naloxone on acetylcholine and noradrenaline release in the guinea-pig isolated distal colon, and have assessed the effect of naloxone on electrically-induced contractions of the longitudinal muscle and non-adrenergic, non-cholinergic (NANC) relaxations of the circular muscle coat. Naloxone dose-dependently increased resting and electrically-evoked acetylcholine release and electrically-evoked noradrenaline release. Naloxone was more potent in increasing resting acetylcholine release in colonic specimens obtained after chronic sympathetic denervation. Naloxone (1 μm ) did not affect electrically-induced contractions of the longitudinal muscle, while it enhanced NANC relaxations of the circular muscle. The effects observed with naloxone in the present experiments suggest that opioid pathways exert a tonic restraint on neurotransmission in the guinea-pig colon. After suppression of the adrenergic inhibitory tone, the functional relevance of opioid pathways seems to be increased. 相似文献
10.
ETTORE BENEDETTI ALFONSO BAVOSO BENEDETTO DI BLASIO VINCENZO PAVONE CARLO PEDONE CLAUDIO TONIOLO GIAN MARIA BONORA 《Chemical biology & drug design》1982,20(4):312-319
A conformational analysis of Piv-l-Pro-d-Pro-OMe was performed in the solid state using i.r. absorption and X-ray diffraction. The tertiary amide bond is in the trans conformation, whereas the tertiary peptide bond is in the cis conformation. The sequence of the, ø angles is F, F*. The preferred conformations of the pivaloylamino group, the pyrrolidine rings, and the ester moiety are also discussed. 相似文献