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1.
MARINA GOBBO LAURA BIONDI FERNANDO FILIRA TOM PIEK RANIERO ROCCHI 《Chemical biology & drug design》1995,45(5):459-465
Syntheses are described of the endo-Lys8a-vespulakinin 1 and of cyclo-Thr6- and cyclo-Nε-Lys-bradykinin. The linear peptides covering the entire sequences of endo-Lys8a-VSK-1 and Thr6-BK, and the decapeptide containing all residues constituting Lys-BK, with a Arg-Lys peptide bond involving the ε-amino function of lysine, were prepared by the solid-phase procedure based on Fmoc chemistry. Cyclization was carried out by the diphenylphosphorazide method. The amino-terminal octapeptide sequence of vespulakinin 1, Fmoc-Thr(tBu)-Ala-Thr(tBu)-Thr(tBu)-Arg(Pmc)-Arg(Pmc)-Arg(Pmc)-Gly-OH, and its Nα-Boc-[(Gal β)Thr3, (Gal β)Thr4]-analogue, were used to prepare Nα-(1–8 VSK 1)-cyclo-Nε-kallidin and Nα-[(Gal β)Thr3, (Gal β)Thr4, 1–8 VSK 1]-cyclo-Nε-kallidin. Peptides and glycopeptides were characterized by amino-acid analysis, optical rotation, analytical HPLC and FAB-MS. Consistent with previous findings, preliminary pharmacological experiments on smooth muscle preparations showed that the cyclic, or partially cyclic, analogues were significatively less potent than the linear ones. © Munksgaard 1995. 相似文献
2.
E. N. KOSMAS C. N. BAXEVANIS M. PAPAMICHAIL & T. KORDOSSIS 《European journal of clinical investigation》1997,27(4):308-315
Our objective was to investigate the initial levels of circulating proinflammatory cytokines, such as interleukin 1β (IL-1β), interleukin 6 (IL-6), and tumour necrosis factor alpha (TNF-α), of certain acute-phase proteins, such as C-reactive protein (CRP), fibrinogen (FBN) and albumin, and of the glycoprotein fibronectin at presentation and their daily variation during the clinical course of community-acquired pneumonia (CAP) in relation to clinical and laboratory indices of infection. Thirty otherwise healthy hospitalized patients aged 48 ± 3 years (mean ± SEM) and with bacteriologically confirmed CAP were studied prospectively. IL-1β and IL-6 were found to be 15-fold higher on admission (122 ± 9 pg mL?1 and 60 ± 4 pg mL?1 respectively), whereas TNF-α was three-fold higher (102 ± 5 pg mL?1) than those of controls, all of them showing a decline towards normal. Initial CRP levels were increased 90-fold (416 ± 1 mg L?1), whereas fibronectin levels were reduced (242 ± 9 mg dL?1). The presence of parapneumonic effusion was associated with a higher TNF-α serum level (127 ± 7 vs. 86 ± 4 pg mL?1, P = 0.0002), a more rapid daily decline in TNF-α (–7.2 ± 0.7 vs. ?3.8 ± 0.5 pg mL?1 day?1, P = 0.0005), a slower rate of decline in CRP (?42.8 ± 3.0 vs. ?54.6 ± 3.0 mg L?1 day?1, P = 0.02) and a slower rate of increase in FBN (5.9 ± 1.0 vs. 11.7 ± 1.0 mg dL?1 day?1), P = 0.001]. Furthermore, daily progression of serum levels of cytokines and acute-phase proteins correlated strongly with pyrexia, erythrocyte sedimentation rate (ESR), neutrophil count, alveolar–arterial oxygen difference and radiographic resolution, clinically manifested by improvement in the patients' condition. 相似文献
3.
4.
SCABID: AN UNUSUAL ID REACTION TO SCABIES 总被引:1,自引:0,他引:1
SARAH BRENNER M.D. RONNI WOLF M.D. MARINA LANDAU M.D. 《International journal of dermatology》1993,32(2):128-129
5.
An ambitious breastfeeding promotion programme was launchedin Brazil in 1981 which included the use of mass media, healthpersonnel training and re-organization of health service routines.A comparison of two health surveys carried out in Greater SãoPaulo before (1981) and after (1987) the implementation of theprogramme showed an important increase in the median durationof breastfeeding from 84 to 146 days, respectively. The potentialimpact of the programme on infant mortality rates has been estimated,using the relative risks associated with breastfeeding obtainedin a case-control study in a similar urban population in southernBrazil. During this period the infant mortality rate in SãoPaulo fell by 49%. The observed change in feeding practicesmay have been responsible for a reduction of 12% of this 49%or, expressed another way, for one-quarter of the observed declinein infant mortality. The calculations suggest that the programmemay have led to reductions in deaths caused by diarrhoea of32%, in respiratory infections of 22% and in deaths due to otherinfections of 17%. 相似文献
6.
GIANFRANCO BUJA ANTONIO F. FOLINO MARINA BITTANTE BRUNO CANClANI BORTOLO MARTINI MANUELA MIORELLI DANIELA TOGNIN DOMENICO CORRADO REA NAVA 《Pacing and clinical electrophysiology : PACE》1989,12(3):406-412
We describe three athletes who had syncope after (case 1) or during (cases 2, 3) hyperventilation. During the episode, ECG showed prolonged sinus arrest. Clinical data and noninvasive investigations were normal and the phenomenon was not reproducible. Electrophysiological study after autonomic blockade allowed a prolonged intrinsic heart rate in case 1, and abnormal corrected sinus node recovery time in cases 1 and 2. During follow-up, symptomatic sinus arrest provoked by deep inspiration occurred in case 3. These cases document prolonged asystole of unknown etiology, secondary to hyperventilation, and probably caused by different vagally-mediated mechanisms. 相似文献
7.
EMMANUEL N. SIMANTIRAKIS EMMANUEL M. KANOUPAKIS GEORGE E. KOCHIADAKIS MARINA K. KANAKARAKI FRAGISKOS I. PARTHENAKIS EMMANUEL G. MANIOS EMMANUEL MARKIANOS PANOS E. VARDAS 《Pacing and clinical electrophysiology : PACE》1998,21(11):2269-2272
This study examined the acute and long-term effects of DDD pacing on ergospirometric parameters and neurohormonal activity in patients with hypertrophic obstructive Cardiomyopathy (HOCM). We studied eight patients (five males), aged 56 ± 7 years, with HOCM refractory to drugs. In all patients a DDD pacemaker was implanted and programmed with an atrioventricular (AV) delay that insured full ventricular activation. The patients underwent echocardiographic examination and exercise stress testing before and 3 days, 3 months, and 12 months after pacemaker implantation. Oxygen consumption was measured at the anaerobic threshold (VO2AT ) and peak exercise (pVO2 ). Atrial natriuretic peptide (ANP) and cyclic adenosine monophosphate (c-AMP) levels were measured concomitantly. Left ventricular outflow tract (LVOT) pressure gradient decreased significantly from 70 ± 18 to 25 ± 12 mmHg (P < 0.05) 3 days after pacing and remained unchanged at 3 and 12 months. pVO2 and VO2AT increased significantly, from 20.1 ± 3 to 23.4 ± 3 mL/kg/min and from 16 ± 3 to 17.8 ± 2 mL/kg/min, respectively (P < 0.05). This improvement continued up to 3 months, and then remained stable until the end of the 12-month follow-up period. ANP levels decreased at 3 days from 85.4 ± 5.7 to 75.4 ± 7.3 fmol/mL (P < 0.05), and remained unchanged over the 12 months. c-AMP levels did not change significantly after the onset of pacing. DDD pacing in patients with HOCM not only reduces the LVOT pressure gradient but also causes a significant early and long-term improvement in exercise capacity and neurohormonal profile. 相似文献
8.
Technical and Clinical Problems in Patients with Simultaneous Implantation of a Cardiac Pacemaker and Spinal Cord Stimulator 总被引:1,自引:0,他引:1
MASSIMO ROMANÓ FURIO ZUCCO MARINA ROTA BALDINI BIAGIO ALLARIA 《Pacing and clinical electrophysiology : PACE》1993,16(8):1639-1644
Spinal cord stimulators are used to relieve pain associated with peripheral ischemia and angina pectoris. In patients with both a permanent pacemaker (PPM) and a spinal cord stimulator (SCS), electromagnetic signals from the SGS may inhibit the PPM. A bipolar PPM configuration is preferred to minimize myopotential or electromagnetic interference but patients have safely had unipolar devices implanted. We report ten patients (six males and four females; median age 73.3 years) with both a SCS and a PPM implanted between 1987–1991. Intermittent interference with one PPM (Ela Medical Model Opus 3001)was noted after an increase in the output voltage of the SCS for continued clinical efficacy. Inhibition was output voltage dependent, and reversion to the noise mode was frequency dependent. Sensitivity to both could he managed by changing the pacemaker sensitivity. Interference with pocemaker function occurred if the SCS output was set above a voltage and pulse duration which resulted in a product of these values above 1.9–2 mVs. Seven VVI, one VDD, and two DDD PPM had been implanted. In five potients hoth PPM and SCS were unipolar. In two patients the SCS was bipolar and the PPM unipolar, in two potients a bipolar PPM was associated with a bipolar SCS and with one patient, a unipolar SCS. Multiprogrammable and/or bipolar PPMs should be implanted in a patient with a SCS to allow reprogramming of the PPM and to minimize the risk of inter-device interference. Inhibition of the PPM may occur at different SCS stimulation frequencies. The frequency at which inhibition occurs varies with different models of implanted pacemaker 相似文献
9.
Soluble interleukin-6 receptor (sIL-6R), a new prognostic factor in multiple myeloma 总被引:6,自引:0,他引:6
MARIA-CHRISTINA KYRTSONIS GEORGES DEDOUSSIS CONSTANTIN ZERVAS VASSILIS PERIFANIS CONSTANTIN BAXEVANIS MARINA STAMATELOU ALICE MANIATIS 《British journal of haematology》1996,93(2):398-400
sIL-6R is a 55 kD soluble molecule mediating the interleukin-6 (IL-6) signal through the IL-6 receptor-associated transmembrane signal transducer, gp130. It has recently been suggested that sIL-6R serum levels may reflect disease severity in multiple myeloma (MM). We determined sIL-6R serum levels in 25 normal controls (NC) and in 80 MM patients at diagnosis and during the course of the disease. Measurements were done by ELISA. In NC, sIL-6R levels ranged from 14 to 40 ng/ml (median 28 ng/ml) whereas in MM patients the range was 10–200 ng/ml (median 38 ng/ml) ( P < 0.01). 61 patients entered remission and 19 were resistant. Median sIL-6R value at diagnosis was 36 ng/ml (10–120) in responding patients, and 82 ng/ml (20–200) in non-responding patients ( P < 0.001). During a follow-up from 12 to 89 months, sIL-6R values remained more or less stable in most patients. High sIL-6R levels correlated with poor survival. 相似文献