全文获取类型
收费全文 | 1878篇 |
免费 | 105篇 |
国内免费 | 12篇 |
专业分类
耳鼻咽喉 | 7篇 |
儿科学 | 53篇 |
妇产科学 | 41篇 |
基础医学 | 194篇 |
口腔科学 | 46篇 |
临床医学 | 122篇 |
内科学 | 490篇 |
皮肤病学 | 18篇 |
神经病学 | 199篇 |
特种医学 | 88篇 |
外科学 | 241篇 |
综合类 | 10篇 |
一般理论 | 2篇 |
预防医学 | 173篇 |
眼科学 | 11篇 |
药学 | 144篇 |
中国医学 | 15篇 |
肿瘤学 | 141篇 |
出版年
2023年 | 11篇 |
2022年 | 19篇 |
2021年 | 57篇 |
2020年 | 25篇 |
2019年 | 44篇 |
2018年 | 50篇 |
2017年 | 35篇 |
2016年 | 51篇 |
2015年 | 46篇 |
2014年 | 56篇 |
2013年 | 87篇 |
2012年 | 120篇 |
2011年 | 139篇 |
2010年 | 69篇 |
2009年 | 57篇 |
2008年 | 110篇 |
2007年 | 119篇 |
2006年 | 122篇 |
2005年 | 103篇 |
2004年 | 98篇 |
2003年 | 90篇 |
2002年 | 89篇 |
2001年 | 28篇 |
2000年 | 23篇 |
1999年 | 35篇 |
1998年 | 20篇 |
1997年 | 15篇 |
1996年 | 12篇 |
1995年 | 15篇 |
1994年 | 9篇 |
1993年 | 8篇 |
1992年 | 24篇 |
1991年 | 22篇 |
1990年 | 13篇 |
1989年 | 20篇 |
1988年 | 20篇 |
1987年 | 11篇 |
1986年 | 9篇 |
1985年 | 11篇 |
1984年 | 14篇 |
1983年 | 12篇 |
1982年 | 11篇 |
1981年 | 5篇 |
1980年 | 6篇 |
1979年 | 9篇 |
1978年 | 4篇 |
1977年 | 4篇 |
1976年 | 6篇 |
1974年 | 4篇 |
1973年 | 6篇 |
排序方式: 共有1995条查询结果,搜索用时 15 毫秒
1.
Ángel Becerra Héctor Trujillo Lucía Valencia Aurelio Rodríguez‐Pérez 《Brazilian Journal of Anesthesiology》2019,69(2):200-203
Background and objectives
A prompt and effective management of trauma patient is necessary. The aim of this case report is to highlight the importance of intraoperative echocardiography as a useful tool in patients suffering from refractory hemodynamic instability no otherwise explained.Case report
A 41 year‐old woman suffered a car accident. At the emergency department, no abnormalities were found in ECG or chest X‐ray. Abdominal ultrasound revealed the presence of abdominal free liquid and the patient was submitted to urgent exploratory laparotomy. Nevertheless, she persisted suffering arterial hypotension and metabolic acidosis. Looking for the reason of her hemodynamic instability, intraoperative transthoracic echocardiography was performed, finding out the presence of pericardial effusion. Once the cardiac surgeon extracted pericardial clots, patient's situation improved clinically and analytically.Conclusion
Every anesthesiologist should be able to use the intraoperative echocardiography as an effective tool in order to establish the appropriate measures to promote the survival of patients suffering severe trauma. 相似文献2.
3.
Reyna O. Calderon B. Maggio T. J. Neuberger G. H. Devries 《Journal of neuroscience research》1993,34(2):206-218
The axolemma membrane forms a stable and reproducible monomolecular layer at the air-aqueous interface. The major lipids and proteins are present in this monolayer in molar ratios similar to the original membrane. Acetylcholinesterase and Na-K-ATPase activities are preserved in the monolayer to levels of 64% and 25%, respectively. The total lipid fraction forms a homogeneously mixed phase. The presence of proteins in the monolayer introduces surface inhomogeneties. Among other features, this is revealed by the presence of two values of lateral pressure at which the monolayer shows partial or total collapse: a broad partial collapse at surface pressures between 13 to 30 mN/m and a sharp collapse point at 46 mN/m. The average molecular areas, the broad collapse point, and the variation of the surface potential per molecule suggest the relocation of protein components at surface pressures between 13 to 30 mN/m. The behavior is consistent with the extrusion and exposure of proteins toward the aqueous medium that depends on the lateral pressure. Schwann cells grown on coverslips coated with axolemma monolayers at 13 mN/m (beginning of the broad collapse) and 34 mN/m (above the broad collapse) recognize the difference in the surface organization of axolemma caused by the lateral pressure which affects their proliferation, morphology, and spatial pattern of organization. Our results show for the first time that response of Schwann cells depends on the intermolecular organization of the axolemma surface with which they interact. These results suggest that the local expression of putative surface molecules of axolemma that may mediate membrane recognition and the signalling of morphological and proliferative changes can be modulated by long range supramolecular properties. © 1993 Wiley-Liss, Inc. 相似文献
4.
5.
6.
7.
Stress signaling through Ca2+/calmodulin-dependent protein phosphatase calcineurin mediates salt adaptation in plants 下载免费PDF全文
Jos M. Pardo Muppala P. Reddy Shuli Yang Albino Maggio Gyung-Hye Huh Tracie Matsumoto Maria A. Coca Matilde Paino-DUrzo Hisashi Koiwa Dae-Jin Yun Abed A. Watad Ray A. Bressan Paul M. Hasegawa 《Proceedings of the National Academy of Sciences of the United States of America》1998,95(16):9681-9686
Calcineurin (CaN) is a Ca2+- and calmodulin-dependent protein phosphatase (PP2B) that, in yeast, is an integral intermediate of a salt-stress signal transduction pathway that effects NaCl tolerance through the regulation of Na+ influx and efflux. A truncated form of the catalytic subunit and the regulatory subunit of yeast CaN were coexpressed in transgenic tobacco plants to reconstitute a constitutively activated phosphatase in vivo. Several different transgenic lines that expressed activated CaN also exhibited substantial NaCl tolerance, and this trait was linked to the genetic inheritance of the CaN transgenes. Enhanced capacity of plants expressing CaN to survive NaCl shock was similar when evaluation was conducted on seedlings in tissue culture raft vessels or plants in hydroponic culture that were transpiring actively. Root growth was less perturbed than shoot growth by NaCl in plants expressing CaN. Also, NaCl stress survival of control shoots was enhanced substantially when grafted onto roots of plants expressing CaN, further implicating a significant function of the phosphatase in the preservation of root integrity during salt shock. Together, these results indicate that in plants, like in yeast, a Ca2+- and calmodulin-dependent CaN signal pathway regulates determinants of salt tolerance required for stress adaptation. Furthermore, modulation of this pathway by expression of an activated regulatory intermediate substantially enhanced salt tolerance. 相似文献
8.
Emilia Lachica Aurelio Luna Enrique Villanueva 《International journal of legal medicine》1989,103(2):111-119
Summary The diagnosis of myocardial infarction requires the use of a group of tests that are very efficient, quick and inexpensive. Another important consideration is the choice of myocardial sampling zones, especially in cases of differential diagnosis between a cardiac injury secondary to a trauma or violent asphyxia and others, secondary to myocardial infarction. The aim of this work was to choose, through discriminant analysis, the most useful zones of cardiac tissue for the quantification of free fatty acids and free carnitine and for the performance of the K/Na quotient, as biochemical parameters for the postmortem diagnosis of myocardial infarction. According to the discriminant analysis performed, seven zones of cardiac tissue are necessary to achieve a differential diagnosis among myocardial infarction, other natural deaths, and violent deaths with a 71.9% efficacy. Greater diagnostic efficacy was found (78.1%) for differentiating between natural deaths and violent deaths.
Offprint requests to: E. Lachica 相似文献
9.
A case of somatostatin-producing pancreatic tumor associated with severe insulindependent diabetes mellitus and ketoacidotic
coma is reported. The tumor, a 10-cm expansile mass arising from the pancreatic tail of a 70-yr-old woman, was first detected
by ultrasonography, performed because of abdominal pain, and subsequently confirmed by computed tomography and fine-needle
tumor aspiration. Pathologic investigation showed a predominatly solid-trabecular structure with scattered microacini and
psammomatous bodies. A large proportion of tumor cells expressed somatostatin and/or calcitonin. Following resection of the
primary tumor and three peripancreatic lymph nodes with metastases, the patient recovered rapidly from her diabetic syndrome
and remained in substantially good health during a subsequent 8-yr follow-up period, without evidence of tumor recurrence. 相似文献
10.
Licata A Ainis L Martella S Ricca MB Licata P Lauriano ER Zaccone G 《Acta histochemica》2002,104(3):289-295
The epidermis of the earthworm Lumbricus terrestris is a multifunctional tissue. It is composed of supporting, mucous, neuroendocrine-like, sensory and basal cells. NO is considered to be a molecule that regulates numerous functional activities (also in non-neuronal cells) in vertebrates. In the earthworm epidermis, we found neuronal NO synthase immunopositivity in orthochromatic and metachromatic mucous cells, neuroendocrine-like cells and in epidermal and subepidermal nerve fibers and striated muscle fibers. It is suggested that NO has a multitude of biological actions, affecting functional activities of the epidermis such as tissue homeostasis, control of secretion, proliferation, respiration, defense, water-salt balance, as well as regulation of tonus in vascular and striated muscles. 相似文献