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Jongnarangsin K Suwanagool A Chugh A Crawford T Good E Pelosi F Bogun F Oral H Morady F 《Journal of cardiovascular electrophysiology》2012,23(1):9-14
Ablation and Progression of Atrial Fibrillation. Objective: The objective was to determine the effect of radiofrequency catheter ablation (RFA) on progression of paroxysmal atrial fibrillation (AF). Background: Progression to persistent AF may occur in up to 50% of patients with paroxysmal AF receiving pharmacological therapy. Hypertension, age, prior transient ischemic event, chronic obstructive pulmonary disease, and heart failure (HATCH score) have been identified as independent risk factors for progression of AF. Methods: RFA was performed in 504 patients (mean age: 58 ± 10 years) to eliminate paroxysmal AF. A repeat RFA procedure was performed in 193 patients (38%). Clinical variables predictive of outcome and their relation to progression of AF after RFA were assessed using multivariate analysis. Results: At a mean follow‐up of 27 ± 12 months after RFA, 434/504 patients (86%) were in sinus rhythm; 49/504 patients (9.5%) continued to have paroxysmal AF; and 14 (3%) were in atrial flutter. Among the 504 patients, 7 (1.5%) progressed to persistent AF. In patients with recurrent AF after RFA, paroxysmal AF progressed to persistent AF in 7/56 (13%, P < 0.001). The progression rate of AF was 0.6% per year after RFA (P < 0.001 compared to 9% per year reported in pharmacologically treated patients). Age >75 years, duration of AF >10 years and diabetes were independent predictors of progression to persistent AF. The HATCH score was not significantly different between patients with paroxysmal AF who did and did not progress to persistent AF (0.7 ± 0.8 vs 1.0 ± 0.5, P = 0.3). Conclusions: Compared to a historical control group of pharmacologically treated patients with paroxysmal AF, RFA appears to reduce the rate of progression of paroxysmal AF to persistent AF. Age, duration of AF, and diabetes are independent risk factors for progression to persistent AF after RFA. (J Cardiovasc Electrophysiol, Vol. 23, pp. 9‐14, January 2012) 相似文献
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Miki Yokokawa Rakesh Latchamsetty Hamid Ghanbari Diego Belardi Akash Makkar Brett Roberts Wouter Saint-Phard Mohamad Sinno Thomas Carrigan Robert Kennedy Arisara Suwanagool Eric Good Thomas Crawford Krit Jongnarangsin Frank Pelosi Frank Bogun Hakan Oral Fred Morady Aman Chugh 《Heart rhythm》2013,10(4):469-476
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Guiot A Jongnarangsin K Chugh A Suwanagool A Latchamsetty R Myles JD Jiang Q Crawford T Good E Pelosi F Bogun F Morady F Oral H 《Journal of cardiovascular electrophysiology》2012,23(1):36-43
Stroke and Atrial Fibrillation Ablation . Introduction: Factors associated with cerebrovascular events (CVEs) after radiofrequency catheter ablation (RFA) of atrial fibrillation (AF) have not been well defined in elderly patients (≥65 years). The purpose of this study was to determine the prevalence and predictors of CVEs after RFA in patients with AF ≥65 years old, in comparison to patients <65 years, and with or without AF. Methods and Results: This study included 508 consecutive patients ≥65 years old (mean age: 70 ± 4 years), who underwent RFA for paroxysmal (297) or persistent (211) AF. A stratified group of 508 patients < 65 years old who underwent RFA for AF served as a control group. All patients were anticoagulated with warfarin for ≥3 months after RFA. A perioperative CVE (≤4 weeks after RFA) occurred in 0.8% and 1% of patients ≥65 and <65 years old, respectively (P = 1). Among the patients ≥65 years old who remained in sinus rhythm after RFA, warfarin was discontinued in 60% and 56% of the patients with a CHADS2 score of 0 and ≥1, respectively. Paroxysmal AF, no history of CVE, and successful RFA were independent predictors of discontinuing warfarin. During a mean follow‐up of 3 ± 2 years, a late CVE (>4 weeks after the RFA) occurred in 15 of 508 (3%) of patients ≥65 years old (1% per year) and in 5 of 508 (1%) patients <65 years old (0.3% per year, P = 0.03). Among patients ≥65 years old, age >75 years old (OR = 4.9, ±95% CI: 3.3–148.5, P = 0.001) was the only independent predictor of a CVE. Among patients <65 years old, body mass index was the only independent predictor of a late CVE (OR = 1.2, ±95% CI: 1.03–1.33, P = 0.02). Conclusions: The risk of a periprocedural CVE after RFA of AF is similar among patients ≥65 and <65 years old. Late CVEs after RFA are more prevalent in older than younger patients with AF, and age >75 years old is the only independent predictor of late CVEs regardless of the rhythm, anticoagulation status, or the CHADS2 score (Congestive heart failure, Hypertension, Age ≥ 75 years, Diabetes mellitus and prior Stroke or transient ischemic attack). (J Cardiovasc Electrophysiol, Vol. 23, pp. 36‐43, January 2012) 相似文献
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Studies on the potential use of CD38 expression as a marker for the efficacy of anti-retroviral therapy in HIV-1-infected patients in Thailand 总被引:2,自引:0,他引:2
Onlamoon N Tabprasit S Suwanagool S Louisirirotchanakul S Ansari AA Pattanapanyasat K 《Virology》2005,341(2):238-247
The monitoring of the efficacy of anti-retroviral therapy (ART) is becoming an important issue in the developing world. The current use of CD4 counts, plasma viral loads, and monitoring of drug-resistant viruses are at present either uninformative or costly. Thus, more new cost-effective and practical techniques need to be established and implemented. Towards this goal, our lab has carried out studies on the potential use of CD38 frequency and density expression by flow analysis as a means to assess the efficacy of ART. Results of our studies using whole blood sample from normal healthy donors indicate that CD38 is expressed by a high frequency of not only CD4+ and CD8+ T cells but also most hematopoietic cell lineages analyzed. Detailed studies of CD38 expression along with other cell surface markers using whole blood sample from HIV-1-infected patients showed that the most discriminating change was the increased frequency and density of CD38 expression by CD3+CD8+ T cells. Of importance was our preliminary finding that a reversal of the increased frequency and density of CD38 expression by CD8+ T cells only appeared in the whole blood sample from patients who were responders to ART but not those who were drug failures. These initial data provide a platform and incentive for larger cohort studies including prospective pre- and post-ART for the institution of such monitoring techniques in resource limited settings. 相似文献
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Pathogenicity of Eikenella corrodens in humans 总被引:6,自引:0,他引:6
S Suwanagool M M Rothkopf S M Smith D LeBlanc R Eng 《Archives of internal medicine》1983,143(12):2265-2268
Eikenella corrodens is resident flora of the normal adult human oral cavity. Four cases of verified infection and previous case reports of infections caused by this organism were reviewed and analyzed. Rarely has this bacillus been found as the sole isolate to initiate infection in the host with normal immune status. In the immunocompromised host, this organism was observed as the sole isolate in cases of persistent empyemas and/or overwhelming pneumonias with bacteremias. The potential of the organism singly to perpetuate an established infection appears real. In the immunocompromised patients such potentials are accentuated and can result in fulminant pulmonary infections and death. The finding of E corrodens in an infection site of a compromised patient should indicate specific therapy. 相似文献
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Robert H. K. Eng M.D. Surapol Suwanagool M.D. Herman Chmel M.D. Sharon M. Smith Ph.D. Flor Tecson-Tumang M.D. Michael Corrado M.D. 《The American journal of gastroenterology》1983,78(2):90-93
Eubacterium is a commensal of the human gastrointestinal tract. In rare instances this organism can become blood-borne. Nine cases of bacteremia were described and eight cases were found in the medical literature. Thirteen of the 17 cases (76%) had active gastrointestinal disease leading to the Eubacterium bacteremia. It is suggested that recovery of Eubacterium in blood culture should alert the clinician to the possibility of active gastrointestinal disease including occult neoplasms. 相似文献
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Sathaporn Manatsathit Somsit Tansupasawasdikul Darawan Wanachiwanawin Surachai Setawarin Parvinee Suwanagool Saranjit Prakasvejakit Somchal Leelakusolwong Boonchuey Eampokalap Udom Kachintorn 《Journal of gastroenterology》1996,31(4):533-537
A prospective study was designed to investigate the causes of chronic diarrhea in AIDS patients in Thailand. Forty-five patients
from Bamrasnaradura Infectious Diseases Hospital were enrolled. Extensive investigations included multiple stool examinations
for ova and parasites, using the stool formalin-ether concentration method, stool culture, stool acid-fast bacilli (AFB) stain,
stool modified AFB stain, esophago-gastroduoscopy with duodenal aspirate and biopsy, and colonoscopy with biopsy. Biopsied
specimens were examined with H&E, Giemsa, Gram, Periodic acid Schiff, and AFB stains. Definitive causes were found in 29 patients
(64.4%). Of these 29, 7 patients were found to habor more than 1 pathogen (15.5%). The most commonly found enteric pathogen
wasCryptosporidium parvum (20.0%). Less frequently found pathogens wereMycobacterium tuberculosis (17.8%),Salmonella spp. (15.5%),Cytomegalovirus (11.1%),Mycobacterium avium intracellulare (6.6%), Strongyloides stercoralis (4.4%),Giardia lamblia (4.4%),Cryptococcus neoformans (2.2%),Histoplasma capsulatum (2.2%),Campylobacter jejun (2.2%), andCyclospora cayetanensis (2.2%).Salmonella spp., Mycobacterium tuberculosis, andMycobacterium avium intracellulare infections were shown to be more common in Thailand than in African countries. 相似文献
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Arisara Prateep Somruethai Sumkhemthong Maneewan Suksomtip Pithi Chanvorachote 《Pharmaceutical biology》2017,55(1):1792-1799
Context: Lentinus squarrosulus Mont. (Polyporaceae) is an interesting source of diverse bioactive compounds.Objective: This is the first study of the anticancer activity and underlying mechanism of peptides extracted from Lentinus squarrosuls.Materials and methods: Peptides were isolated from the aqueous extract of L. squarrosulus by employing solid ammonium sulphate precipitation. They were further purified by ion-exchange chromatography on diethylaminoethanol (DEAE)-cellulose and gel filtration chromatography on Sephadex G25. Anticancer activity was investigated in human lung cancer H460, H292 and H23 cells cultured with 0–40?μg/mL of peptide extracts for 24?h. Cell viability and mode of cell death were evaluated by MTT and nuclear staining assay, respectively. Western blotting was used to investigate the alteration of apoptosis-regulating proteins in lung cancer cells treated with peptide extracts (0–20?μg/mL) for 24?h.Results: The cytotoxicity of partially-purified peptide extracts from L. squarrosulus was indicated with IC50 of ~26.84?±?2.84, 2.80?±?2.14 and 18.84?±?0.30?μg/mL in lung cancer H460, H292 and H23 cells, respectively. The extracts at 20?μg/mL induced apoptosis through the reduction of anti-apoptotic Bcl-2 protein (~0.5-fold reduction) and up-regulation of BAX (~4.5-fold induction), a pro-apoptotic protein. Furthermore, L. squarrosulus peptide extracts (20?μg/mL) also decreased the cellular level of death receptor inhibitor c-FLIP (~0.6-fold reduction).Conclusions and discussion: This study provides the novel anticancer activity and mechanism of L. squarrosulus peptide extracts, which encourage further investigation and development of the extracts for anticancer use. 相似文献