全文获取类型
收费全文 | 7736篇 |
免费 | 512篇 |
国内免费 | 51篇 |
专业分类
耳鼻咽喉 | 35篇 |
儿科学 | 186篇 |
妇产科学 | 209篇 |
基础医学 | 1211篇 |
口腔科学 | 94篇 |
临床医学 | 627篇 |
内科学 | 2108篇 |
皮肤病学 | 285篇 |
神经病学 | 706篇 |
特种医学 | 182篇 |
外科学 | 790篇 |
综合类 | 18篇 |
一般理论 | 3篇 |
预防医学 | 455篇 |
眼科学 | 106篇 |
药学 | 438篇 |
中国医学 | 28篇 |
肿瘤学 | 818篇 |
出版年
2024年 | 7篇 |
2023年 | 62篇 |
2022年 | 165篇 |
2021年 | 248篇 |
2020年 | 143篇 |
2019年 | 216篇 |
2018年 | 240篇 |
2017年 | 179篇 |
2016年 | 208篇 |
2015年 | 248篇 |
2014年 | 315篇 |
2013年 | 383篇 |
2012年 | 557篇 |
2011年 | 623篇 |
2010年 | 331篇 |
2009年 | 286篇 |
2008年 | 484篇 |
2007年 | 472篇 |
2006年 | 497篇 |
2005年 | 440篇 |
2004年 | 441篇 |
2003年 | 360篇 |
2002年 | 352篇 |
2001年 | 98篇 |
2000年 | 74篇 |
1999年 | 88篇 |
1998年 | 74篇 |
1997年 | 74篇 |
1996年 | 65篇 |
1995年 | 57篇 |
1994年 | 41篇 |
1993年 | 48篇 |
1992年 | 56篇 |
1991年 | 64篇 |
1990年 | 42篇 |
1989年 | 37篇 |
1988年 | 36篇 |
1987年 | 23篇 |
1986年 | 19篇 |
1985年 | 20篇 |
1984年 | 15篇 |
1983年 | 15篇 |
1981年 | 8篇 |
1980年 | 9篇 |
1979年 | 9篇 |
1978年 | 6篇 |
1977年 | 14篇 |
1976年 | 10篇 |
1973年 | 7篇 |
1966年 | 5篇 |
排序方式: 共有8299条查询结果,搜索用时 15 毫秒
1.
Exhaled nitric oxide in children with allergic rhinitis: A potential biomarker of asthma development
下载免费PDF全文
![点击此处可从《Pediatric allergy and immunology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
2.
Alessandro Vatrella Angelantonio Maglio Corrado Pelaia Girolamo Pelaia Carolina Vitale 《Expert opinion on pharmacotherapy》2020,21(12):1505-1515
ABSTRACT
Introduction
‘Critical Asthma Syndrome’ (CAS) is an umbrella term proposed to include several forms of asthma, responsible for acute and life-threatening exacerbations. CAS requires urgent and adequate supportive and pharmacological treatments to prevent serious outcomes. 相似文献3.
4.
Neuropsychological Findings: Myoclonic Astatic Epilepsy (MAE) and Lennox-Gastaut Syndrome (LGS) 总被引:1,自引:0,他引:1
Melissa Filippini Antonella Boni Gloria Dazzani Angelo Guerra Giuseppe Gobbi 《Epilepsia》2006,47(S2):56-59
Summary: Purpose: To identify a specific neuropsychological profile associated with myoclonic astatic epilepsy (MAE) and Lennox-Gastaut syndrome (LGS).
Methods: Seven patients diagnosed with MAE and four patients diagnosed with LGS were selected from patients referred to our Child Neurology Unit. The patients were assessed both clinically (awake, sleep, Holter EEG, seizures frequency, and semiology) and neuropsychologically (IQ, language, attention, visuospatial and visuomotor abilities, and behavior). One representative case of each syndrome is presented here.
Results: The clinical picture of the MAE patient resembled that of an MAE condition associated with transitory epileptic encephalopathy. The neuropsychological findings suggest that electroclinical anomalies can temporarily affect cognitive and behavioral functioning. Early effective antiepileptic drug (AED) treatment was found to improve cognitive outcome. In contrast, LGS was associated with mental retardation, which persisted after seizure control.
Conclusions: At present, it remains difficult to delineate a precise neuropsychological profile associated with MAE and LGS. The cognitive outcome of MAE is variable and depends on the clinical pattern. With regard to LGS, the hypothesis of a genetic predisposition underlying both the epilepsy and the mental retardation is still valid. Alternatively, exposure to subclinical electrophysiological anomalies during a critical period of cerebral development may be responsible for the mental retardation. At the time the clinical manifestations appear, drug treatment, even if effective, would have only limited impact on cognitive outcome. However, early multidisciplinary intervention may help to improve behavior and communicative abilities, enhancing the quality of life of these children and their families. 相似文献
Methods: Seven patients diagnosed with MAE and four patients diagnosed with LGS were selected from patients referred to our Child Neurology Unit. The patients were assessed both clinically (awake, sleep, Holter EEG, seizures frequency, and semiology) and neuropsychologically (IQ, language, attention, visuospatial and visuomotor abilities, and behavior). One representative case of each syndrome is presented here.
Results: The clinical picture of the MAE patient resembled that of an MAE condition associated with transitory epileptic encephalopathy. The neuropsychological findings suggest that electroclinical anomalies can temporarily affect cognitive and behavioral functioning. Early effective antiepileptic drug (AED) treatment was found to improve cognitive outcome. In contrast, LGS was associated with mental retardation, which persisted after seizure control.
Conclusions: At present, it remains difficult to delineate a precise neuropsychological profile associated with MAE and LGS. The cognitive outcome of MAE is variable and depends on the clinical pattern. With regard to LGS, the hypothesis of a genetic predisposition underlying both the epilepsy and the mental retardation is still valid. Alternatively, exposure to subclinical electrophysiological anomalies during a critical period of cerebral development may be responsible for the mental retardation. At the time the clinical manifestations appear, drug treatment, even if effective, would have only limited impact on cognitive outcome. However, early multidisciplinary intervention may help to improve behavior and communicative abilities, enhancing the quality of life of these children and their families. 相似文献
5.
6.
Nafarelin controlled release injectable (CRI) releases a decapeptide drug for target one month therapy. Nafarelin, a luteinizing hormone releasing hormone agonistic analogue, is microencapsulated in biodegradable poly(lactide-co-glycolide) microspheres and given by intramuscular injection. Clinical data from a human single dose Phase I clinical study are modelled to develop theoretical multiple dose profiles and theoretical single dose profiles from mixtures of two or three formulations. Single dose injections of nafarelin CRI microspheres (4 mg nafarelin) containing 2, 4, or 7 per cent nafarelin all achieve useful plasma drug levels throughout the target 30 day interval. Therapeutic suppression of testosterone levels was observed in all subjects participating in the phase I clinical study. Highest plasma nafarelin levels are achieved in the 0-10 and 20-35 day post-injection intervals. Theoretical multiple dosing profiles generated from the single dose clinical results show significant oscillations in plasma nafarelin levels depending on the particular dosing interval selected. Thirty or forty day dosing intervals yield significant variability in plasma nafarelin levels at steady state; 15 day dosing intervals show less variability. Therapeutic testosterone suppression was observed in the single dose study, so the nafarelin dose per injection can be reduced in multiple dosing therapies. Theoretical plasma nafarelin profiles from certain mixtures of 2 and 4 per cent nafarelin microspheres or 2 and 7 per cent nafarelin microspheres indicate that a 60 day product could be achieved. In general, all three formulations yield their lowest plasma drug levels during the 10-20 day post-injection interval. Therefore any mixture of these formulations will likewise exhibit low plasma drug levels during this interval. 相似文献
7.
N Scopinaro E Gianetta D Friedman G F Adami E Traverso B Vitale M Castagnola G Semino M Summa V Bachi 《Gastroenterology Clinics of North America》1987,16(3):529-531
Biliopancreatic diversion is a very effective method for weight reduction. In some instances it is too effective and needs to be revised. 相似文献
8.
9.
Rebecca Voltan Arianna Castaldello Egidio Brocca-Cofano Rita De Michele Chiara Triulzi Giuseppe Altavilla Luisa Tondelli Michele Laus Katia Sparnacci Eva Reali Riccardo Gavioli Barbara Ensoli Antonella Caputo 《Vaccine》2009
Cationic block copolymers spontaneously assemble via electrostatic interactions with DNA molecules in aqueous solution giving rise to micellar structures that protect the DNA from enzymatic degradation both in vitro and in vivo. In addition, we have previously shown that they are safe, not immunogenic and greatly increased antigen-specific CTL responses following six intramuscular inoculations of a very low dose (1 μg) of the vaccine DNA as compared to naked DNA. Nevertheless, they failed to elicit detectable humoral responses against the antigen. To gain further insight in the potential application of this technology, here we show that a shorter immunization protocol based on two DNA intramuscular inoculations of 1 μg of DNA delivered by these copolymers and a protein boost elicits in mice broad (both humoral and cellular) and long-lasting responses and increases the antigen-specific Th1-type T cell responses and CTLs as compared to priming with naked DNA. These results indicate that cationic block copolymers represent a promising adjuvant and delivery technology for DNA vaccination strategies aimed at combating intracellular pathogens. 相似文献
10.
Angelo M. Carella Sandro Nati Paolo Carlier Daniela Pierluigi Domenico Giordano Angela Congiu Gino Santini Daniele Scarpati Salvina Barra Renzo Corvo Vito Vitale Maria R. Raffo Raffaella Cerri Marco Risso Mauro Spriano Renato Vimercati Ester Pungolino Andrea Bacigalupo Eugenio Damasio 《Leukemia & lymphoma》1991,5(1):43-47
Forty consecutive adult patients under the age of 50 with acute non-lymphoblastic leukemia (ANLL) in first complete remission, underwent autologous bone marrow transplantation (ABMT) between March 1984 and April 1990. The conditioning regimen employed included cyclophosphamide and total body irradiation, followed by the administration of unpurged ABMT. The median time from diagnosis to transplant was 7 months (3-15 months), and the median time from complete remission to ABMT was 4 months (range 3-9 months). Twenty-two (51%) patients remain in complete remission 6-81 months (median 24 months) after ABMT.
The causes of death were, recurrent leukemia (11 patients), parenchymal toxicities such as acute respiratory distress syndrome and veno-occlusive disease (3 patients), hemorrhage (2 patients) and infection (2 patients). Eleven patients relapsed after 3-12 months (median 5 months). This study has produced survival data comparable to those of other institutions employing TBI for either allo or autotransplants. 相似文献
The causes of death were, recurrent leukemia (11 patients), parenchymal toxicities such as acute respiratory distress syndrome and veno-occlusive disease (3 patients), hemorrhage (2 patients) and infection (2 patients). Eleven patients relapsed after 3-12 months (median 5 months). This study has produced survival data comparable to those of other institutions employing TBI for either allo or autotransplants. 相似文献