全文获取类型
收费全文 | 44492篇 |
免费 | 3016篇 |
国内免费 | 154篇 |
专业分类
耳鼻咽喉 | 447篇 |
儿科学 | 1095篇 |
妇产科学 | 1011篇 |
基础医学 | 5915篇 |
口腔科学 | 739篇 |
临床医学 | 4264篇 |
内科学 | 8705篇 |
皮肤病学 | 676篇 |
神经病学 | 4496篇 |
特种医学 | 1479篇 |
外科学 | 7483篇 |
综合类 | 535篇 |
现状与发展 | 1篇 |
一般理论 | 40篇 |
预防医学 | 3557篇 |
眼科学 | 1096篇 |
药学 | 2937篇 |
中国医学 | 125篇 |
肿瘤学 | 3061篇 |
出版年
2023年 | 229篇 |
2022年 | 309篇 |
2021年 | 960篇 |
2020年 | 619篇 |
2019年 | 881篇 |
2018年 | 1095篇 |
2017年 | 805篇 |
2016年 | 813篇 |
2015年 | 947篇 |
2014年 | 1477篇 |
2013年 | 1936篇 |
2012年 | 3078篇 |
2011年 | 3257篇 |
2010年 | 1847篇 |
2009年 | 1665篇 |
2008年 | 2983篇 |
2007年 | 3175篇 |
2006年 | 2990篇 |
2005年 | 2931篇 |
2004年 | 2809篇 |
2003年 | 2675篇 |
2002年 | 2453篇 |
2001年 | 442篇 |
2000年 | 406篇 |
1999年 | 445篇 |
1998年 | 503篇 |
1997年 | 449篇 |
1996年 | 435篇 |
1995年 | 369篇 |
1994年 | 344篇 |
1993年 | 297篇 |
1992年 | 279篇 |
1991年 | 245篇 |
1990年 | 211篇 |
1989年 | 200篇 |
1988年 | 221篇 |
1987年 | 198篇 |
1986年 | 178篇 |
1985年 | 178篇 |
1984年 | 183篇 |
1983年 | 185篇 |
1982年 | 213篇 |
1981年 | 198篇 |
1980年 | 168篇 |
1979年 | 106篇 |
1978年 | 139篇 |
1977年 | 134篇 |
1976年 | 105篇 |
1975年 | 107篇 |
1974年 | 94篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
Ali Mobasheri Csaba Matta Ilona Uzielienè Emma Budd Pablo Martín-Vasallo Eiva Bernotiene 《Joint, bone, spine : revue du rhumatisme》2019,86(1):29-35
Chondrocytes are the main cells in the extracellular matrix (ECM) of articular cartilage and possess a highly differentiated phenotype that is the hallmark of the unique physiological functions of this specialised load-bearing connective tissue. The plasma membrane of articular chondrocytes contains a rich and diverse complement of membrane proteins, known as the membranome, which defines the cell surface phenotype of the cells. The membranome is a key target of pharmacological agents and is important for chondrocyte function. It includes channels, transporters, enzymes, receptors, and anchors for intracellular, cytoskeletal and ECM proteins and other macromolecular complexes. The chondrocyte channelome is a sub-compartment of the membranome and includes a complete set of ion channels and porins expressed in these cells. Many of these are multi-functional proteins with “moonlighting” roles, serving as channels, receptors and signalling components of larger molecular assemblies. The aim of this review is to summarise our current knowledge of the fundamental aspects of the chondrocyte channelome, discuss its relevance to cartilage biology and highlight its possible role in the pathogenesis of osteoarthritis (OA). Excessive and inappropriate mechanical loads, an inflammatory micro-environment, alternative splicing of channel components or accumulation of basic calcium phosphate crystals can result in an altered chondrocyte channelome impairing its function. Alterations in Ca2+ signalling may lead to defective synthesis of ECM macromolecules and aggravated catabolic responses in chondrocytes, which is an important and relatively unexplored aspect of the complex and poorly understood mechanism of OA development. 相似文献
2.
Lauren Tingey Britta Mullany Rachel Chambers Ranelda Hastings Angelita Lee Anthony Parker 《AIDS care》2015,27(9):1087-1097
Potential for widespread transmission of HIV/AIDS among American Indian (AI) adolescents exists, yet no evidence-based interventions (EBIs) have been adapted and evaluated with this population. Intensive psychoeducation may improve knowledge and decision-making which could potentially translate to reductions in HIV risk behaviors. A peer group randomized controlled comparison of an adapted EBI vs. control was delivered over an eight-day summer basketball camp in one reservation-based tribal community to adolescents ages 13–19. Outcome data were gathered immediately post-camp and at 6 and 12 months follow-up. Self-selected peer groups were randomized to intervention (n = 138) or control (n = 129) conditions for a total sample of 267 participants (56.2% female), mean age 15.1 years (SD = 1.7). Intervention participants had better condom use self-efficacy post-camp (Adjusted Mean Difference [AMD] = ?0.75, p < 0.005) and at 6 (AMD = ?0.44, p < 0.005) and 12 months (AMD = ?0.23, p < 0.05) follow-up. Intervention participants also had higher HIV prevention and transmission knowledge (post-camp: AMD = 0.07, p < 0.01; 6 months: AMD = 0.06, p < 0.01) were more likely to believe condoms prevent sexually transmitted infections (post-camp: RR = 1.41, p < 0.005; 6 months: RR = 1.34, p < 0.05), to talk with an adult about HIV/AIDS (post-camp: RR=1.78, p < 0.005; 6 months: RR = 1.14, p < 0.005), had higher partner negotiation efficacy related to substance use during sex (post-camp: AMD = 0.37, p < 0.01), and were more likely to intend to use a condom (post-camp: RR = 1.39, p < 0.01). The adapted intervention had short- and medium-term impacts on AI adolescent risk for HIV/AIDS, but attenuated at 12 months. Intervention delivery through a community-based camp is feasible and acceptable with strong retention. Additional study is needed to evaluate the adapted intervention's impact on sexual risk behaviors and if booster sessions and parent involvement translate to long-term impacts. 相似文献
3.
4.
5.
6.
7.
8.
Anthony R. Flores Brittany E. Jewell Erika M. Versalovic Randall J. Olsen Beth A. Bachert Slawomir Lukomski James M. Musser 《Infection and immunity》2015,83(3):1122-1129
Group A Streptococcus (GAS) predominantly exists as a colonizer of the human oropharynx that occasionally breaches epithelial barriers to cause invasive diseases. Despite the frequency of GAS carriage, few investigations into the contributory molecular mechanisms exist. To this end, we identified a naturally occurring polymorphism in the gene encoding the streptococcal collagen-like protein A (SclA) in GAS carrier strains. All previously sequenced invasive serotype M3 GAS possess a premature stop codon in the sclA gene truncating the protein. The carrier polymorphism is predicted to restore SclA function and was infrequently identified by targeted DNA sequencing in invasive strains of the same serotype. We demonstrate that a strain with the carrier sclA allele expressed a full-length SclA protein, while the strain with the invasive sclA allele expressed a truncated variant. An isoallelic mutant invasive strain with the carrier sclA allele exhibited decreased virulence in a mouse model of invasive disease and decreased multiplication in human blood. Further, the isoallelic invasive strain with the carrier sclA allele persisted in the mouse nasopharynx and had increased adherence to cultured epithelial cells. Repair of the premature stop codon in the invasive sclA allele restored the ability to bind the extracellular matrix proteins laminin and cellular fibronectin. These data demonstrate that a mutation in GAS carrier strains increases adherence and decreases virulence and suggest selection against increased adherence in GAS invasive isolates. 相似文献
9.