首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   53720篇
  免费   3570篇
  国内免费   266篇
耳鼻咽喉   522篇
儿科学   1938篇
妇产科学   1370篇
基础医学   8025篇
口腔科学   793篇
临床医学   5163篇
内科学   12144篇
皮肤病学   1174篇
神经病学   5901篇
特种医学   1125篇
外科学   4365篇
综合类   298篇
现状与发展   1篇
一般理论   43篇
预防医学   5028篇
眼科学   869篇
药学   4059篇
中国医学   136篇
肿瘤学   4602篇
  2024年   91篇
  2023年   682篇
  2022年   1440篇
  2021年   2428篇
  2020年   1397篇
  2019年   1790篇
  2018年   1969篇
  2017年   1594篇
  2016年   1757篇
  2015年   1903篇
  2014年   2474篇
  2013年   3103篇
  2012年   4565篇
  2011年   4571篇
  2010年   2424篇
  2009年   2072篇
  2008年   3449篇
  2007年   3441篇
  2006年   3104篇
  2005年   2826篇
  2004年   2617篇
  2003年   2333篇
  2002年   2105篇
  2001年   240篇
  2000年   184篇
  1999年   253篇
  1998年   337篇
  1997年   287篇
  1996年   193篇
  1995年   184篇
  1994年   183篇
  1993年   143篇
  1992年   97篇
  1991年   83篇
  1990年   65篇
  1989年   76篇
  1988年   72篇
  1987年   64篇
  1986年   59篇
  1985年   59篇
  1984年   83篇
  1983年   67篇
  1982年   78篇
  1981年   66篇
  1980年   61篇
  1979年   29篇
  1978年   33篇
  1977年   34篇
  1976年   25篇
  1975年   20篇
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
2.
Abstract

Supporting patients in making informed healthcare decisions is a cornerstone of ethical medical practice. Surgeons frequently draw for and show images to patients when consenting them for operations but the value of this practice in informed decision-making is unclear. An audit was conducted in a General Surgery Department. 244 patients completed questionnaires on the value of visual materials when giving consent for surgery. The complexity of the operations was classified into “simple”, “moderate” or “complex”. 100% of patients felt they had given informed consent to surgery. 62% of patients received at least one form of visual material during the consenting process. All patients who received a drawing, and 99% of those provided with other images, valued these resources. Visual materials were considered more useful to patients when giving consent for moderate or complex operations than simple ones. Approximately one third of patients who did not receive visual materials would have appreciated these when making an informed decision. This research highlights the value of surgeons drawing for, and providing other visual resources to, their patients as part of the consent process. There is a role for further research and training materials in drawing skills for surgeons.  相似文献   
3.
4.
5.
6.
7.
8.

Background

Rosacea is a chronic inflammatory skin condition whose etiology has been linked to mast cells and the antimicrobial peptide cathelicidin LL-37. Individuals with refractory disease have demonstrated clinical benefit with periodic injections of onabotulinum toxin, but the mechanism of action is unknown.

Objectives

To investigate the molecular mechanism by which botulinum toxin improves rosacea lesions.

Methods

Primary human and murine mast cells were pretreated with onabotulinum toxin A or B or control. Mast cell degranulation was evaluated by β-hexosaminidase activity. Expression of botulinum toxin receptor Sv2 was measured by qPCR. The presence of SNAP-25 and VAMP2 was established by immunofluorescence. In vivo rosacea model was established by intradermally injecting LL-37 with or without onabotulinum toxin A pretreatment. Mast cell degranulation was assessed in vivo by histologic counts. Rosacea biomarkers were analyzed by qPCR of mouse skin sections.

Results

Onabotulinum toxin A and B inhibited compound 48/80-induced degranulation of both human and murine mast cells. Expression of Sv2 was established in mouse mast cells. Onabotulinum toxin A and B increased cleaved SNAP-25 and decreased VAMP2 staining in mast cells respectively. In mice, injection of onabotulinum toxin A significantly reduced LL-37-induced skin erythema, mast cell degranulation, and mRNA expression of rosacea biomarkers.

Conclusions

These findings suggest that onabotulinum toxin reduces rosacea-associated skin inflammation by directly inhibiting mast cell degranulation. Periodic applications of onabotulinum toxin may be an effective therapy for refractory rosacea and deserves further study.  相似文献   
9.
10.
The jobs of Latino manual laborers place their mental and physical health at risk. This study evaluates the associations among musculoskeletal pain, mental health, and work organization in Latino manual laborers. Farmworkers and nonfarmworkers (n = 189) in North Carolina were interviewed for self-reported musculoskeletal pain, depressive symptoms, stress, work safety climate, and precarious job status. More nonfarmworkers than farmworkers had neck and shoulder pain, but they did not differ in other areas of musculoskeletal pain. Depressive symptoms had a significant association with neck and shoulder pain (p < .05). Precariousness had a significant association with back pain (p < .05). Farmworker participants had H-2A visas and were afforded some protection compared to nonfarmworker manual workers. Research is needed to improve policy that relieves pain and improves mental health for all Latino manual workers.  相似文献   
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号