全文获取类型
收费全文 | 1472篇 |
免费 | 84篇 |
国内免费 | 32篇 |
专业分类
耳鼻咽喉 | 32篇 |
儿科学 | 32篇 |
妇产科学 | 26篇 |
基础医学 | 136篇 |
口腔科学 | 16篇 |
临床医学 | 122篇 |
内科学 | 349篇 |
皮肤病学 | 19篇 |
神经病学 | 77篇 |
特种医学 | 33篇 |
外科学 | 428篇 |
综合类 | 36篇 |
预防医学 | 125篇 |
眼科学 | 23篇 |
药学 | 87篇 |
中国医学 | 5篇 |
肿瘤学 | 42篇 |
出版年
2023年 | 15篇 |
2022年 | 25篇 |
2021年 | 52篇 |
2020年 | 29篇 |
2019年 | 34篇 |
2018年 | 51篇 |
2017年 | 30篇 |
2016年 | 27篇 |
2015年 | 25篇 |
2014年 | 45篇 |
2013年 | 53篇 |
2012年 | 125篇 |
2011年 | 130篇 |
2010年 | 58篇 |
2009年 | 60篇 |
2008年 | 124篇 |
2007年 | 103篇 |
2006年 | 83篇 |
2005年 | 74篇 |
2004年 | 91篇 |
2003年 | 70篇 |
2002年 | 83篇 |
2001年 | 22篇 |
2000年 | 19篇 |
1999年 | 18篇 |
1998年 | 16篇 |
1997年 | 7篇 |
1996年 | 6篇 |
1995年 | 7篇 |
1994年 | 10篇 |
1993年 | 5篇 |
1992年 | 7篇 |
1991年 | 6篇 |
1990年 | 6篇 |
1989年 | 4篇 |
1988年 | 3篇 |
1987年 | 5篇 |
1985年 | 4篇 |
1984年 | 6篇 |
1983年 | 2篇 |
1982年 | 3篇 |
1981年 | 5篇 |
1980年 | 3篇 |
1979年 | 4篇 |
1978年 | 9篇 |
1977年 | 2篇 |
1976年 | 2篇 |
1972年 | 3篇 |
1967年 | 4篇 |
1960年 | 2篇 |
排序方式: 共有1588条查询结果,搜索用时 265 毫秒
1.
2.
3.
Philanthotoxin blocks quisqualate-, AMPA- and kainate-, but not NMDA-, induced excitation of rat brainstem neurones in vivo. 总被引:1,自引:0,他引:1 下载免费PDF全文
1. The effect of electrophoretic ejection of philanthotoxin (the polyamine toxin, from the Egyptian digger wasp) was tested on responses of brainstem and spinal neurones in the pentobarbitone-anaesthetized rat to excitatory amino acids. 2. Philanthotoxin caused a dose-dependent reduction of responses to quisqualate, alpha-amino-3-hydroxy-5-phenyl-4-isoxazolepropionate (AMPA) and kainate with little effect on those to N-methyl-D-aspartate (NMDA). 3. The time-course of this antagonist action was slow. In particular the rate of recovery was dependent on frequency of ejection of the agonist. This agonist-dependent recovery suggests that philanthotoxin has a channel blocking mode of action on mammalian central neurones. 相似文献
4.
Recombinant tumor necrosis factor alpha does not inhibit the growth of African trypanosomes in axenic cultures 下载免费PDF全文
Kitani H Black SJ Nakamura Y Naessens J Murphy NB Yokomizo Y Gibson J Iraqi F 《Infection and immunity》2002,70(4):2210-2214
Mice whose tumor necrosis factor alpha (TNF-alpha) genes were disrupted developed higher levels of parasitemia than wild-type mice following infection with Trypanosoma congolense IL1180 or T. brucei brucei GUTat3.1, confirming the results of earlier studies. To determine whether TNF-alpha directly affects the growth of these and other bloodstream forms of African trypanosomes, we studied the effects of recombinant mouse, human, and bovine TNF-alpha on the growth of two isolates of T. congolense, IL1180 and IL3338, and two isolates of T. brucei brucei, GUTat3.1 and ILTat1.1, under axenic culture conditions. The preparations of recombinant TNF-alpha used were biologically active as determined by their capacity to kill L929 cells. Of five recombinant TNF-alpha lots tested, one lot of mouse TNF-alpha inhibited the growth of both isolates of T. brucei brucei and one lot of bovine TNF-alpha inhibited the growth of T. brucei brucei ILTat1.1 but only at very high concentrations and without causing detectable killing of the parasites. The other lots of mouse recombinant TNF-alpha, as well as human TNF-alpha, did not affect the growth of any of the test trypanosomes even at maximal concentrations that could be attained in the culture systems (3,000 to 15,000 U of TNF-alpha/ml of medium). These results suggest that exogenously added recombinant TNF-alpha generally does not inhibit the growth of African trypanosomes under the culture conditions we used. The impact of TNF-alpha on trypanosome parasitemia may be indirect, at least with respect to the four strains of trypanosomes reported here. 相似文献
5.
6.
Amel Rezgui Maissa Thabet Sahar Makki Jihed Anoun Imen Ben Hassine Monia Karmeni Fatma Ben Fredj Anis Mzabi Chedia Laouani 《Reumatologia》2021,59(2):111
Coexistence of spondyloarthritis (SpA) and Takayasu’s arteritis is not a common finding, but such cases have been discussed, particularly in the context of choice of therapy. Inhibition of inflammation by tumor necrosis factor inhibitors (TNFi) is a key aspect of the treatment of SpA and also positive effects of such treatment in concomitant large vessel vasculitis have been reported. However, TNFi is also associated with the possibility of initiating vasculitis.The present article based on a case study and the available literature is an attempt to discuss coexistence of these two diseases and the impact of treatment with biological drugs from the anti-TNF group in the course of SpA with Takayasu’s arteritis. 相似文献
7.
BACKGROUND AND METHODS: The introduction of routine measles immunization in Israel in 1967 was followed by a 95% reduction in reported measles incidence. In 1990, a second measles immunization dose was instituted, and up until the end of 1999, 16 birth cohorts were offered the second dose. We present here changes in reported measles incidence in Israel following institution of the two-dose policy. RESULTS: First-dose coverage is 94%, and coverage for the second school-based dose exceeds 95%. A further 90% reduction in measles incidence has been observed and, following a modest national outbreak in 1994, measles incidence for 1995-99 stands at less than 3/100,000/year. CONCLUSIONS: Since measles is highly contagious, very high immunization coverage rates will be required to preserve these accomplishments, and measles elimination is still years away, but there is tentative evidence that measles containment is at hand. Even greater measles control can be anticipated as vaccine immunogenicity improves and successive cohorts of children come under the 2-dose regimen. 相似文献
8.
This is a retrospective study involving 100 anovulatory women with polycystic ovarian syndrome (PCOS) who had laparoscopic ovarian drilling (LOD) between January 1995 and May 2002 at the Royal Berkshire Hospital, Reading, a large district general hospital (DGH). The aim was to evaluate the efficacy of LOD in the treatment of women with anovulatory PCOS in a DGH setting. We also looked at the factors predicting the clinical outcome to be able to counsel the patients pre-operatively. The study showed that the spontaneous pregnancy rate after LOD was 32.46%. A further 28.5% conceived after induction of ovulation with clomiphene citrate (CC) or purified follicular stimulating hormone (Metrodin HP), with a cumulative pregnancy rate of 74%. We did not find a significant difference in the luteinising hormone to follicular stimulating hormone (LH:FSH) ratio of greater than 2.5, LH level of greater than 10 IU/l, body mass index (BMI), age or duration of infertility between the group of women who conceived and those who failed to conceive, in response to LOD. 相似文献
9.
10.