全文获取类型
收费全文 | 301篇 |
免费 | 11篇 |
专业分类
儿科学 | 7篇 |
妇产科学 | 33篇 |
基础医学 | 23篇 |
口腔科学 | 40篇 |
临床医学 | 20篇 |
内科学 | 48篇 |
神经病学 | 17篇 |
特种医学 | 3篇 |
外科学 | 47篇 |
综合类 | 1篇 |
一般理论 | 1篇 |
预防医学 | 46篇 |
眼科学 | 2篇 |
药学 | 14篇 |
中国医学 | 3篇 |
肿瘤学 | 7篇 |
出版年
2022年 | 3篇 |
2021年 | 12篇 |
2020年 | 3篇 |
2019年 | 8篇 |
2018年 | 9篇 |
2017年 | 3篇 |
2016年 | 3篇 |
2015年 | 2篇 |
2014年 | 15篇 |
2013年 | 11篇 |
2012年 | 15篇 |
2011年 | 23篇 |
2010年 | 17篇 |
2009年 | 16篇 |
2008年 | 24篇 |
2007年 | 24篇 |
2006年 | 22篇 |
2005年 | 20篇 |
2004年 | 13篇 |
2003年 | 7篇 |
2002年 | 10篇 |
2001年 | 1篇 |
2000年 | 2篇 |
1999年 | 2篇 |
1998年 | 2篇 |
1997年 | 1篇 |
1996年 | 2篇 |
1994年 | 2篇 |
1993年 | 1篇 |
1992年 | 2篇 |
1991年 | 1篇 |
1990年 | 1篇 |
1989年 | 6篇 |
1988年 | 2篇 |
1984年 | 4篇 |
1983年 | 1篇 |
1982年 | 4篇 |
1981年 | 5篇 |
1980年 | 2篇 |
1979年 | 2篇 |
1978年 | 2篇 |
1977年 | 1篇 |
1976年 | 1篇 |
1973年 | 1篇 |
1966年 | 1篇 |
1964年 | 2篇 |
1962年 | 1篇 |
排序方式: 共有312条查询结果,搜索用时 15 毫秒
1.
Atilio Migues MD Gaston Slullitel MD Anibal Vescovo MD Felipe Droblas MD Marina Carrasco MD Hugo Perrin Turenne MD 《The Journal of foot and ankle surgery》2005,44(5):1043-357
The majority of foot and ankle operations are performed on an outpatient basis and often under some form of regional anesthesia. In this prospective, randomized study of 51 patients undergoing elective unilateral forefoot procedures, we compared 2 different anesthetic techniques: the peripheral foot blockade and the popliteal sciatic nerve block. Variables assessed included the quality of surgical anesthesia, postoperative analgesia, and the incidence of postoperative complications. The anesthesia was classified as effective if it was the sole anesthetic technique for the forefoot surgery. We found successful results in both groups: 92% in the foot block group and 96% in the popliteal block group. Analysis of time required to perform the anesthetic procedure showed a significant difference between the 2 groups, with foot block being considerably faster (14.3 minutes vs 19.2 minutes for popliteal block) (P = .0078). Foot block patients demonstrated 10.96 hours of analgesia, whereas popliteal block patients exhibited 14.32 hours (P = .132). With a mean follow-up of 5.7 months, we did not find anesthesia-related complications in any of the patients. Both techniques showed a high level of safety and efficacy, with no significant difference detected between them. Our patients showed a high rate of satisfaction with both procedures (96% for foot block patients and 96.1% for popliteal block patients) and reported a good discharge disposition. These data show that both procedures are safe and effective anesthetic techniques and well suited to forefoot ambulatory surgery. 相似文献
2.
Cristina García-Amador Vladimir Arteaga Peralta Roberto de la Plaza Llamas Miguel Torralba Anibal Medina Velasco José Manuel Ramia 《Cirugía espa?ola》2021,99(4):282-288
BackgroundTo analyze whether clinical and analytical parameters differ according to histopathology in cases of acute appendicitis (AA).MethodsThis is a retrospective, observational study including patients (>14 years of age) admitted for suspicion of AA from 1 April 2014 to 31 July 2016. Histopathology was divided into complicated (including perforated and gangrenous AA) and uncomplicated appendicitis (phlegmonous). Sex, age, temperature of patients on admission to the Emergency Department, symptom duration, preoperative white blood cell (WBC) count, neutrophil percentage, mean platelet volume (MPV), platelet distribution width (PDW), C-reactive protein (CRP) and hospital stay were compared in the two groups.ResultsThree hundred and thirty-five patients were analyzed, and 284 were included. Appendicitis was uncomplicated in 194 (68.3%) and complicated in 90 (31.7%). Age, symptom duration, neutrophil percentage, CRP and hospital stay were higher in the complicated AA group (P < .05). The mean differences between uncomplicated and complicated AA were: age 13.2 years (95% CI: 8.2-18.2), symptom duration 14.1 hours (95% CI: 6.3-21.9), neutrophil percentage 5.0% (95% CI: 3.2-6.8), CRP 73.6 mg/l (95% CI: 50.0-97.2) and hospital stay 2.2 days (95% CI: 1.4-3.0), with p<0.05 for all these variables. A model based on the preoperative parameters (age, symptom duration, neutrophil percentage and CRP) was calculated to predict the likelihood of complicated AA. The receiver operating characteristic (ROC) of the model had an area under the curve of 0.80 (95% CI 0.75-0.85).ConclusionThis model is able to diagnose complicated AA without the need for imaging techniques, although it must be validated with prospective analysis. 相似文献
3.
Secretory breast carcinoma is a rare tumor originally described in children and adolescent women with a characteristic morphology and a controversial choice of treatment. We report an additional case of a 4-year-old girl with a breast tumor diagnosed as a secretory carcinoma without involvement of the axillary lymph nodes. The therapy consisted of simple mastectomy and low axillary dissection. She presented with a local recurrence near the surgical scar 8 months later, and a wide elliptical excision of the scar and underlying tissue was performed with subsequent radiotherapy of the surgical bed. This tumor has a relatively benign behavior and rarely metastasizes. A literature review revealed only 22 cases of breast carcinoma in childhood and adolescence. ▪ 相似文献
4.
5.
Cryolite, Na3[AlF6], is essential to commercial aluminium production because alumina is readily soluble in molten cryolite. While the liquid state has been extensively investigated, the spectroscopy of the solid state has been largely ignored. In this paper, we show that the structure at 5 K is the same as that at room temperature. We use a combination of infrared and Raman spectroscopies together with inelastic neutron scattering (INS) spectroscopy. The use of INS enables access to all of the modes of Na3[AlF6], including those that are forbidden to the optical spectroscopies. Our spectral assignments are supported by density functional theory calculations of the complete unit cell.We use a combination of infrared, Raman and inelastic neutron scattering spectroscopies to access all of the modes of cryolite, Na3[AlF6], including those that are forbidden to the optical spectroscopies. 相似文献
6.
Pérez Aisa A Nuevo J López Morante AA González Galilea A Martin de Argila C Aviñoa Arreal D Feu F Borda Celaya F Gisbert JP Pérez Roldan F Gonzalvo Sorribes JM Palazón Azorín JM Ponce Romero M Castro Fernández M Catalina Rodriguez MV Gallego Montañés S Calvet X Rodrigo Saez L Montoro Huguet M González Méndez Y Sierra Hernández A Sánchez Hernández E Dominguez Muñoz E Pérez Cuadrado E Muñoz M Lanas A 《Gastroenterologia y hepatologia》2012,35(7):468-475
7.
Chehaibou Ismael Manoharan Niranjan Govetto Andrea Francone Anibal Andrés Sarraf David Hubschman Jean-Pierre 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》2020,258(12):2611-2619
Graefe's Archive for Clinical and Experimental Ophthalmology - To evaluate and compare the rate and characteristics of vitreoretinal disorders in fellow eyes of lamellar macular holes (LMH)... 相似文献
8.
David E. Martin Jose Flavio A. De Almeida Michael A. Henry Zin Z. Khaing Christine E. Schmidt Fabricio B. Teixeira Anibal Diogenes 《Journal of endodontics》2014
Introduction
Intracanal disinfection is a crucial step in regenerative endodontic procedures. Most published cases suggest the use of sodium hypochlorite (NaOCl) as the primary irrigant. However, the effect of clinically used concentrations of NaOCl on the survival and differentiation of stem cells is largely unknown. In this study, we tested the effect of various concentrations of NaOCl on the stem cells of the apical papilla (SCAPs) survival and dentin sialophosphoprotein (DSPP) expression.Methods
Standardized root canals were created in extracted human teeth and irrigated with NaOCl (0.5%, 1.5%, 3%, or 6%) followed by 17% EDTA or sterile saline. SCAPs in a hyaluronic acid–based scaffold were seeded into the canals and cultured for 7 days. Next, viable cells were quantified using a luminescence assay, and DSPP expression was evaluated using quantitative real-time polymerase chain reaction.Results
There was a significant reduction in survival and DSPP expression in the group treated with 6% NaOCl compared with the untreated control group. Comparable survival was observed in the groups treated with the lower concentrations of NaOCl, but greater DSPP expression was observed in the 1.5% NaOCl group. In addition, 17% EDTA resulted in increased survival and DSPP expression partially reversing the deleterious effects of NaOCl.Conclusions
Collectively, the results suggest that dentin conditioning with high concentrations of NaOCl has a profound negative effect on the survival and differentiation of SCAPs. However, this effect can be prevented with the use of 1.5% NaOCl followed by 17% EDTA. The inclusion of this irrigation regimen might be beneficial in regenerative endodontic procedures. 相似文献9.
Introduction
The controlled delivery of bioactive molecules is crucial for the regulation of stem cell differentiation. In this study, we examined the effects of temporal-controlled release of bovine serum albumin (BSA) from chitosan nanoparticles (CSnp) to regulate the alkaline phosphatase activity (ALP) in stem cells from apical papilla (SCAP).Methods
BSA-loaded CSnp were synthesized by 2 methods to achieve the variant temporal-controlled release: (1) the encapsulation technique (BSA-CSnpI) and (2) the adsorption technique (BSA-CSnpII). After characterization of the size, charge, and release kinetics, SCAP were cultured in the presence of these bioactive molecule–loaded nanoparticles. SCAP viability was analyzed at 1, 7, 14, 21, and 28 days, and ALP activity was analyzed every 7 days until 21 days to determine the effect of these bioactive molecule–releasing nanoparticles on the cytotoxicity and differentiation potential, respectively.Results
BSA-CSnpI and BSA-CSnpII presented distinct in vitro release profiles of BSA in a time-controlled manner. Cell viability was significantly enhanced over time in the presence of BSA-CSnpI and BSA-CSnpII (P < .01), when compared with BSA nonloaded CSnp. ALP activity was significantly higher (P < .01) in the presence of BSA-CSnpI after 3 weeks than in BSA-CSnpII.Conclusions
BSA-loaded CSnps were synthesized and characterized in this study. Based on the physical/chemical interaction of BSA with CSnp (encapsulation or surface adsorption), different time-controlled release profiles were observed that influenced the ALP activity of SCAP in vitro. This study highlighted the potential of temporal-controlled bioactive molecule release technology in the differentiation of stem cells in dentin pulp regeneration. 相似文献10.
Eduardo Bartholomay Ismael Polli Anibal Pires Borges Carlos Kalil André Arroque Ilmar Kohler Luiz Cláudio Danzmann 《Clinics (S?o Paulo, Brazil)》2014,69(9):615-620