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Summary
The direct oral anticoagulants (DOACs) are therapeutic alternatives to warfarin and other vitamin K antagonists (VKAs), and constitute the standard of care for many indications. VKAs constitute the conventional therapy for the treatment and secondary thromboprophylaxis of thrombotic antiphospholipid syndrome (APS), but are often problematic, owing to the variable sensitivity of thromboplastins to lupus anticoagulant. Thus, the International Normalized Ratio may not accurately reflect anticoagulation intensity, or be clinically effective. Definition of the current role of DOACs in the treatment of APS is based on limited clinical trial data and information from other sources, including manufacturers’ data, case series or cohort studies, and expert consensus. The Rivaroxaban in Antiphospholipid Syndrome (RAPS) randomized controlled trial (RCT), which had a laboratory surrogate primary outcome measure, suggests that rivaroxaban has the potential to be an effective and convenient alternative to warfarin in thrombotic APS patients with a single venous thromboembolism event requiring standard‐intensity anticoagulation. However, further studies, in particular to provide better long‐term efficacy and safety data, are needed before it can be widely recommended. APS patients are clinically heterogeneous, with the risk of recurrent thrombosis and the intensity of anticoagulation being influenced by their clinical phenotype and risk profile. DOAC trials involving homogeneous thrombotic APS populations, with the antiphospholipid antibody status well defined, will help to optimize the appropriate treatment in APS patient subgroups. Ongoing and emerging DOAC RCTs should provide further information to guide the use of DOACs in APS patients. Optimal identification of APS patients is a key step in working towards improved therapeutic strategies in these individuals.4.
Maria Sokratous MD Marianthi Breza MD MSc Konstantin Senkevich MD PhD Ziv Gan-Or MD PhD Stefania Kalampokini MD MSc PhD Cleanthi Spanaki MD PhD Antonios Provatas MD PhD Zane Zaunmuktane PhD Varvara Valotassiou MD PhD Panagiotis Georgoulias MD PhD Stephanie Efthymiou Georgios M. Hadjigeorgiou MD PhD Henry Houlden MD PhD Georgia Xiromerisiou MD PhD 《Movement disorders》2021,36(9):2209-2212
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Maltezou HC Pappa O Nikolopoulos G Ftika L Maragos A Kaitsa H Protonotariou E Diza E Georgiadis N Vatopoulos A Nicolaidis P 《American journal of infection control》2012,40(1):75-77
In June 2010, a severe outbreak of 13 cases of post-cataract surgery endophthalmitis caused by multidrug-resistant Pseudomonas aeruginosa occurred. Pulse-field gel electrophoresis in eye isolates found 95% genetic similarity; however, extensive environmental and carriage investigation revealed no source of infection. 相似文献
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V. Chelban M. Alsagob K. Kloth A. Chirita‐Emandi J. Vandrovcova R. Maroofian I. Davagnanam S. Bakhtiari M. D. AlSayed Z. Rahbeeni H. AlZaidan N. T. Malintan J. Johannsen S. Efthymiou E. Ghayoor Karimiani K. Mankad S. A. Al‐Shahrani M. Beiraghi Toosi M. AlShammari S. Groppa N. A. Haridy L. AlQuait A. Qari R. Huma M. A. Salih R. Almass F. B. Almutairi M. H. Hamad I. A. Alorainy K. Ramzan F. Imtiaz M. Puiu M. C. Kruer T. Bierhals N. W. Wood D. Colak H. Houlden N. Kaya 《European journal of neurology》2020,27(2):334-342
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Evangelia Papatriantafyllou Dimitris Efthymiou Evangelos Zoumbaneas Codruta Alina Popescu Emilia Vassilopoulou 《Nutrients》2022,14(8)
This narrative review presents the findings from intervention studies on the effects of sleep deprivation on eating habits, metabolic rate, and the hormones regulating metabolism, and discusses their relevance to weight loss efforts. Disturbed sleeping patterns lead to increased energy intake, partly from excessive snacking, mainly on foods high in fat and carbohydrates. The studies focused mainly on the effects of sleep duration, but also of sleep quality, on dietary intake during weight loss trials, and on weight loss maintenance. It is important to explore sleep routines that could enhance the efforts of obese and overweight people to lose weight, maintain their weight loss, and improve their overall health. 相似文献
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