全文获取类型
收费全文 | 1492篇 |
免费 | 86篇 |
国内免费 | 5篇 |
专业分类
耳鼻咽喉 | 4篇 |
儿科学 | 36篇 |
妇产科学 | 50篇 |
基础医学 | 150篇 |
口腔科学 | 12篇 |
临床医学 | 148篇 |
内科学 | 298篇 |
皮肤病学 | 122篇 |
神经病学 | 177篇 |
特种医学 | 16篇 |
外科学 | 161篇 |
综合类 | 19篇 |
预防医学 | 106篇 |
眼科学 | 84篇 |
药学 | 96篇 |
肿瘤学 | 104篇 |
出版年
2023年 | 19篇 |
2022年 | 28篇 |
2021年 | 75篇 |
2020年 | 40篇 |
2019年 | 56篇 |
2018年 | 64篇 |
2017年 | 46篇 |
2016年 | 28篇 |
2015年 | 30篇 |
2014年 | 44篇 |
2013年 | 78篇 |
2012年 | 95篇 |
2011年 | 83篇 |
2010年 | 34篇 |
2009年 | 46篇 |
2008年 | 67篇 |
2007年 | 67篇 |
2006年 | 76篇 |
2005年 | 58篇 |
2004年 | 58篇 |
2003年 | 66篇 |
2002年 | 44篇 |
2001年 | 21篇 |
2000年 | 25篇 |
1999年 | 17篇 |
1998年 | 16篇 |
1997年 | 7篇 |
1994年 | 6篇 |
1993年 | 5篇 |
1992年 | 10篇 |
1991年 | 10篇 |
1990年 | 22篇 |
1989年 | 15篇 |
1988年 | 17篇 |
1987年 | 14篇 |
1986年 | 11篇 |
1985年 | 14篇 |
1984年 | 9篇 |
1982年 | 6篇 |
1979年 | 12篇 |
1978年 | 7篇 |
1977年 | 6篇 |
1975年 | 13篇 |
1974年 | 13篇 |
1973年 | 23篇 |
1972年 | 12篇 |
1971年 | 8篇 |
1970年 | 9篇 |
1969年 | 7篇 |
1967年 | 6篇 |
排序方式: 共有1583条查询结果,搜索用时 15 毫秒
1.
Teichmann Karoline 《Zeitschrift für die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie》1940,107(6):732-745
Research in Experimental Medicine - An Kaulquappen von Rana und Bufo und Mesenterien erwachsener Frösche wird nach Injektion fluorescierender Farbstoffe (Natriumfluorescein und Aesculin) unter... 相似文献
2.
Differential Stripping: Determination of the Amount of Topically Applied Substances Penetrated into the Hair Follicles 下载免费PDF全文
Alexa Teichmann Ute Jacobi Michael Ossadnik† Heike Richter Stefan Koch† Wolfram Sterry Jürgen Lademann 《Journal of general internal medicine》2005,20(5):264-269
The determination of penetration pathways of topically applied substances into the skin is the subject of several investigations. Recently, follicular penetration has become a major focus of interest. To date, a direct, non-invasive quantification of the amount of topically applied substance penetrated into the follicles had not been possible. The development of such a method was the aim of this study. Therefore, the advantages of both stripping techniques, tape stripping and cyanoacrylate skin surface biopsy, were combined and evaluated. Tape stripping was used to remove the part of the stratum corneum that contained the topically applied dye. Subsequently, the follicular contents were ripped off by cyanoacrylate skin surface biopsy. The combined method termed "differential stripping" was evaluated in vitro and in vivo , and the amount of topically applied fluorescent dye penetrated into the hair follicles was quantified after different penetration times. After 30 min, 5% of the recovered concentration of sodium fluorescein was found in the follicular infundibula, where it was still detectable after 48 h. Altogether, the results of this investigation revealed that differential stripping is a new method that can be used to study the penetration of topically applied substances into the follicular infundibula non-invasively and selectively. 相似文献
3.
4.
5.
G Enders R Ruckdeschel R Teichmann W Brendel 《Scandinavian journal of gastroenterology》1988,23(3):301-306
We have investigated the influence of proximal gastric vagotomy in rats (PGV) on the immunoglobulin concentration in the serum, bile, and intestinal fluid. Clear differences for serum IgA were noted: after PGV, rats had 1.5 mg/ml IgA in contrast to only 0.25 mg/ml in sham-operated controls. The other serum immunoglobulins remained unchanged. Bile immunoglobulins were elevated in PGV rats with regard to IgA, IgG1, IgG2a, and IgG2b. In addition, PGV rats had higher IgA, IgG1, IgG2a, and IgG2b concentrations in the intestinal fluid than controls. An explanation for these high Ig concentrations in the secretions might be the challenge by intestinal (microbial) antigens and, perhaps, mucosal inflammation with changes in the permeability. Indications for the former were the increase in the number of bacteria after PGV. 相似文献
6.
This study examined the influence of metamemory (i.e., self-report of memory ability and skills), in combination with other factors, on quality of life for people with multiple sclerosis (MS). Participants (482 persons with MS) completed instruments to measure functional limitations, depressive symptoms, metamemory, and perceived quality of life. Participants reported greater satisfaction with their memory performance but less frequent use of memory aids and strategies compared with 115 older adults on whom the instrument was originally tested. Components of metamemory were significantly related to neurological disability, duration of disease, depressive symptoms, age, and quality of life. Depressive symptoms had a higher impact than other variables in the final regression model on quality-of-life prediction. 相似文献
7.
8.
Dr. Ernst Teichmann 《Medical microbiology and immunology》1916,82(3):511-526
Ohne Zusammenfassung 相似文献
9.
Immune reactions associated with silicone-based ventriculo-peritoneal shunt malfunctions in children
VandeVord PJ Gupta N Wilson RB Vinuya RZ Schaefer CJ Canady AI Wooley PH 《Biomaterials》2004,25(17):3853-3860
The implantation of ventriculo-peritoneal (VP) shunting systems is the most commonly performed neurological procedure in children with hydrocephalus. Although the overall complication risk is low, the cumulative risk of shunt failure is high and unfortunately results in a high prevalence of revision surgeries. In this study, we explored the concept that some pediatric patients may develop an immune response to either the proteins attached to the silicone implant surface or to the biomaterial itself, and that this reaction may contribute to VP shunt failure in some individuals. The data displays that the sterile shunt malfunction group had a higher rate of protein deposition and increased levels of autoantibodies to the extracted surface proteins as compared to individuals with functioning shunting systems. The precise nature of the shunt-bound proteins that serve as antigens in this experiment have not yet been determined. The data also indicated that some individuals develop antibodies to polymeric substances that cross-react with partially polymerized acrylamide. The detection of significant amounts of shunt-bound protein, antibody responses to these proteins and to polymeric substances suggest that an immunological response to these proteins may play a role in the mechanism behind sterile shunt malfunctions. 相似文献
10.
Histone deposition protein Asf1 maintains DNA replisome integrity and interacts with replication factor C 总被引:9,自引:0,他引:9 下载免费PDF全文
Chromatin assembly and DNA replication are temporally coupled, and DNA replication in the absence of histone synthesis causes inviability. Here we demonstrate that chromatin assembly factor Asf1 also affects DNA replication. In budding yeast cells lacking Asf1, the amounts of several DNA replication proteins, including replication factor C (RFC), proliferating cell nuclear antigen (PCNA), and DNA polymerase epsilon (Pol epsilon), are reduced at stalled replication forks. In contrast, DNA polymerase alpha (Pol alpha) accumulates to higher than normal levels at stalled forks in asf1Delta cells. Using purified, recombinant proteins, we demonstrate that RFC directly binds Asf1 and can recruit Asf1 to DNA molecules in vitro. We conclude that histone chaperone protein Asf1 maintains a subset of replication elongation factors at stalled replication forks and directly interacts with the replication machinery. 相似文献