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1.
2.
Time course of hypo-osmotic swellings of human spermatozoa: evidence of ordered transition between swelling subtypes 总被引:2,自引:1,他引:2
Hossain AM; Rizk B; Barik S; Huff C; Thorneycroft IH 《Human reproduction (Oxford, England)》1998,13(6):1578-1583
The hypo-osmotic swelling test (HOST or HOS test) usually takes into
consideration the total HOS response value with no emphasis either on the
value of the response subtypes or the response evaluation time. This study
investigated the time course of HOS responses and analysed their
physiological relevance. Raw semen spermatozoa and Percoll washed
spermatozoa were used in the experiment. The morphological changes in the
sperm tail were monitored by incubating the spermatozoa in the hypo-
osmotic solution for 16 different time periods. The HOS reactive
spermatozoa and the type of HOS reaction (swelling subtypes) of the samples
subjected to different duration of treatment were identified under a phase
contrast microscope. Also the fate of individual spermatozoa in a
hypo-osmotic environment were monitored for 30 min. In spermatozoa exposed
to a hypo-osmotic solution, the motility lasted usually less than 2 min and
motility characteristics were uniquely different from that of the
spermatozoa under iso-osmotic conditions. The HOS response development was
permanent but the motility loss due to hypo-osmotic shock was reversible up
to 1 min of incubation. There was an indication of ordered transition among
the HOS swelling subtypes apparently initiating with subtype b destined to
c, d, e, f and g. Further, the subtypes a and g showed gradual decrease and
increase, respectively, while subtype b showed abrupt initial increase and
then gradual decrease. Transition from b to g could be direct or via one or
more than one subtypes. Ultrastructure based analysis indicated that HOS
response subtypes are the apparent reflection of the differences in the
cytoskeletal assembly of the sperm tail and thus may be identifying
different physiological variants in the sperm population. These results
indicate that shorter incubation is essential to document the kinetics of
various HOS responses but the conventional HOS test misses these important
HOS features because of lengthy incubation. Since the time course of
ordered transition of HOS responses will vary more than the total HOS
response in semen of different aetiologies, the importance of HOS response
subtypes and response evaluation time should be taken into consideration
when applying HOS test.
相似文献
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4.
Solitary intestinal fibromatosis (SIF) is very rare; only 9 cases have been described. A new case presenting unusually in a newborn is described and the previously reported cases are reviewed. SIF should be considered in the differential diagnosis of a newborn presenting with an intestinal perforation. 相似文献
5.
Hyperhomocysteinaemia and Risk of Thrombosis in Systemic Lupus Erythematosus Patients 总被引:4,自引:0,他引:4
Hyperhomocysteinaemia is strongly associated with increased relative risk of occlusive vascular disease, mainly of the carotid
and coronary arteries. The aim of our study was to assess whether raised plasma homocysteine is a risk factor for thrombotic
events in patients with systemic lupus erythematosus (SLE), a condition known to be associated with premature atherothrombotic
complications. The study included 34 consecutive consenting SLE patients who were seen in the Rheumatology Unit of Al-Amiri
hospital, one of the main teaching hospitals in Kuwait. Twenty consenting healthy subjects were included in the control group.
Twenty-four patients were grouped as SLE without thrombosis and 10 had different types of thromboses. Vitamin B12, folate, anticardiolipin antibodies (IgG and IgM), activated partial thromboplastin time (APTT) and total homocysteine level
were measured for both patients and controls. A raised homocysteine concentration was defined as plasma homocysteine level
above 9.4 mmol/l. Hyperhomocysteinaemia was found in 21 (61.8%) SLE patients. Low levels of folate and vitamin B12 were significantly associated with high concentrations of plasma homocysteine (r = −0.35 and −0.39, respectively, P<0.01). SLE patients with elevated homocysteine concentration have a threefold increase in odds ratio of thrombotic events
after adjusting for other risk factors (male sex, shortened APTT, treatment with prednisone, low folate and vitamin B12 levels). We concluded that homocysteine is an independent risk factor for thrombosis in patients with SLE and is potentially
modifiable.
Received: 27 December 2001 / Accepted: 14 April 2002
Correspondence and offprint requests to: Dr I. H. Al-Salem, PO Box 16434, Al-Qadeseyah 35855, Kuwait. Tel: 965 2532025; Fax: 965 2666205; E-mail: driqbalham@hotmail.com 相似文献
6.
7.
目的:肺癌分期与肿瘤直径的关系已被证实是一个预后指标,因此被纳入1986年肺癌分类的国际系统。近年来由于CT飞速发展,人们可以诊断出更小的肺癌,于是有人提倡对肺癌Ⅰ期进一步分期,即根据肿瘤直径小于还是大于30mm,将无确切远处淋巴结转移的病例(Ⅰ期病例)细分为Ⅰa和Ⅰb期。在诊断无症状(即潜伏)的肺癌时,CT普查的开展使人们考虑肿瘤大小的预后价值。在此我们对CT普查诊断的无症状潜伏型肺癌作了分期与大小关系的报道。 相似文献
8.
Abdulla Alwabari Lalit Parida Ahmed Hassan Al-Salem 《Pediatric surgery international》2009,25(5):417-421
Background In 1991, Delaitre reported the first laparoscopic splenectomy (LS). Since then LS has become the procedure of choice to treat
hematological diseases requiring splenectomy. The Eastern province of Saudi Arabia is known to have a high incidence of hemoglobinopathies
including sickle cell disease (SCD), which is known to be associated with complications necessitating splenectomy and/or cholecystectomy.
This report describes our experience with LS and/or laparoscopic cholecystectomy (LC) for children with SCD.
Patients and methods The medical records of all children with SCD who had LS and/or LC were retrospectively reviewed for age, sex, indication for
splenectomy, operative time, hospital stay, and post-operative complications. The results were compared to a similar group
of children with SCD who had open splenectomy (OS) and/or open cholecystectomy (OC).
Results Over a period of 3.5 years (January 2005 and June 2008), a total of 45 children had LS with or without LC, 30 (66.7%) of them
had SCD. Their age ranged from 2 to 12 years (mean 7 years). There were 16 males and 14 females. In all, LS was done because
of recurrent splenic sequestration crisis except one who had a large spleen with multiple infarcts that was causing abdominal
pain. The operative time ranged from 1.5 to 9 h (mean 2.75 h). Their hospital stay ranged from 3 to 9 days (mean 4.5 days).
There was no mortality. Two patients (6.7%) required conversion to OS due to a large-sized spleen and severe adhesions in
one and uncontrolled intra-operative bleeding in the other. The results were compared to a group of 120 children with SCD
who had OS only (88) and OS with OC (32). From 1994 to 2006, a total of 55 children had LC only, 47 (26 M:21 F) of them (85.5%)
had SCD. Their age ranged from 4 to 15 years (mean 11.4 years). The indications for cholecystectomy were: biliary dyspepsia
(20), biliary colic (35), acute cholecystitis (5), obstructive jaundice (5), asymptomatic (6), and biliary pancreatitis (1).
There was no mortality, but one (2.1%) required conversion to OC because of severe adhesions and another underwent postoperative
exploration because of bleeding from an accessory cystic artery. The results were compared to a similar group of 27 children
with SCD who underwent OC.
Conclusions With good peri-operative management, LS is feasible and safe in children with SCD and can be done concomitantly with cholecystectomy.
Currently, it requires more operative time than the open approach. This is specially so for children with SCD who are known
to have a large spleen with severe adhesions. It is, however, superior to OS with regard to duration of hospital stay, cosmetic
appearance, post-operative complications, and post-operative recovery. LC is also safe in children with SCD. When compared
with OC, it is associated with less post-operative complications, a shorter hospital stay, better cosmetic appearance and
a faster recovery. 相似文献
9.
Al-Salem AH 《Pediatric surgery international》2000,16(5-6):433-436
Congenital spigelian hernia (SH) is very rare in the pediatric age group. This is a report of two cases of SH in 1-week and
3-month-old male infants. A review of the literature revealed only 35 cases of SH in children younger than 17 years of age,
bringing the total including our 2 cases to 37. There were 25 males and 12 females, a ratio of 2.1:1. Their ages ranged from
6 days to 17 years (mean 4.52 years). The hernia was situated on the right side in 13, the left side in 19, and was bilateral
in 4. In one case the side of the hernia was not mentioned. In 29 cases the hernia was spontaneous while in 5 it was caused
by trauma. In 3 children the hernia developed postoperatively, in 2 following repair of a congenital diaphragmatic hernia
and in 1 following excision of a mediastinal neuroblastoma. Two children presented with a strangulated SH. Eleven of the 35
previously reported children had associated conditions; in 5 there was an ipsilateral undescended testis (UDT). Our two infants
with SH also had an ipsilateral UDT. The significance of this association is discussed.
Accepted: 26 April 1999 相似文献
10.