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1.
Laparoscopic surgery has several advantages over traditional surgery because it has been shown to be less invasive. The next logical step in the evolution of minimally invasive surgery may be to eliminate all abdominal incisions. The natural orifices provide a port of entry via the gastrointestinal tract to the peritoneal cavity. This approach would require the creation of a perforation, which is considered to be a major complication of endoscopy with significant morbidity and mortality. However, there are several recent studies that have described the technical feasibility and safety of a per‐oral transgastric approach to the peritoneal cavity using conventional endoscopes. Theoretically, this approach could reduce postoperative abdominal wall pain, wound infection, hernia formation, and adhesions. This article aims to summarize the current status of transgastric surgery, currently referred to as natural orifice transluminal endoscopic surgery (NOTES), and to address some of its future challenges.  相似文献   
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Changes in plasma amino acids, 24-h nitrogen balances, and resting metabolic expenditures (RMEs) were measured in 10 geriatric patients (aged 70-92 y) with hip fracture 1 d after surgical fixation during both a 24-h fasting state and while receiving total peripheral parenteral nutrition (TPPN) for 24 h at 1.5 g amino acids.kg-1.d-1 and 29-30 kcal.kg-1.d-1 and compared with 19 healthy volunteer subjects (aged 70-84 y). RME and 24-h urinary nitrogen losses were also elevated in the trauma patients during both fasting and TPPN. Positive nitrogen balances were evident in both groups during TPPN. Plasma total amino acid concentration was significantly lower in the trauma patients because of lower plasma concentrations of the nonessential amino acids. Phenylalanine and methionine concentrations were significantly higher and lysine lower in the trauma group. In addition, evaluation of the essential amino acid ratios after fasting and TPPN reveal that there are no limiting amino acids during TPPN.  相似文献   
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Pain during sexual activity and ejaculation are the unspoken long-term complications of groin hernia repair. Laparoscopic surgical techniques are associated with decreased post-operative pain and earlier return to daily activities, but its effect on these complications is unclear. This study aims to investigate the effect of transabdominal preperitoneal repair (TAPP) on de-novo pain during sexual intercourse and ejaculation and to compare with open repair. For this reason, two groups were determined according to the surgical technique: the Lichtenstein repair and the TAPP groups and a questionnaire was sent to the patients a minimum of 6 months following the surgery. A total of 317 patients included, as 115 in TAPP and 202 in Lichtenstein repair group. No significant difference was observed concerning pre-operative pain during sexual activity and ejaculation in both groups (p = .75, p = .56). Following the surgery, the number of patients experiencing painful sexual activity was significantly higher in the Lichtenstein repair group compared to the TAPP group (19.3% vs. 11.3%, respectively, p = .03). The post-operative painful ejaculation rate was also significantly lower for the TAPP group (p = .04). The lower rates of post-operative dysejaculation and pain during sexual activity can be achieved with the advantage of laparoscopic surgery.  相似文献   
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1.  Naja flava venom heated to 100° C for 15 minutes interferes with intracerebrally inducedBrunhilde andLansing poliomyelitis infection in rhesus monkeys when the blockading agent is administered subcutaneously 24 hours after infection.
2.  It is suggested that this interference mechanism is based on the direct action of the heated venom on motoneurons, as evidenced by histopathologic changes in the spinal cords of normal rhesus monkeys injected subcutaneously with the venom.
3.  Similar histopathologic changes are seen when large doses ofNaja flava toxoid are injected subcutaneously into normal rhesus monkeys.
4.  An attempt has been made to extend the interpretation of the neurotoxoid and neurotoxin interference mechanism in poliomyelitis by correlating enzymatic studies of other workers with cobra venom and with chromatolytic cells refractory to poliomyelitis infection.
1.  Wird dasNaja-flava-Gift durch 15 Minuten auf 100° C erhitzt, dann hemmt es die intracerebral eingebrachteBrunhilde- undLansing-Poliomyelitis-Infektion bei Rhesusaffen, wenn das blockierende Agens 24 Stunden nach der Infektion subkutan zugeführt wird.
2.  Es wird angenommen, daß dieser Hemmungsmechanismus auf der direkten Einwirkung des erhitzten Giftes auf die Motoneurone beruht, was durch histopathologische Veränderungen im Rückenmark normaler Rhesusaffen, denen das Gift subkutan injiziert wurde, bewiesen wird.
3.  Ähnliche histopathologische Veränderungen werden bemerkt, wenn starke Dosen desNaja-flava-Toxoids normalen Rhesusaffen subkutan injiziert werden.
4.  Es wurde der Versuch gemacht, die Erklärung des Neurotoxoid- und Neurotoxin-Hemmungsmechanismus bei der Poliomyelitis durch die Vergleichung enzymatischer Studien anderer Forscher am Kobra-Gift und an chromatolytischen Zellen, die der Poliomyelitis-Infektion Widerstand leisten, zu erweitern.

With 7 Figures.  相似文献   
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We report a case of Takayasu's disease with severe renovascular hypertension in a girl from Eritrea. In the "burn-out" phase after the erythrocyte sedimentation rate had normalized, reconstructive vascular surgery was performed as further progression of the disease seemed unlikely. However, probably due to her growth, the graft rotated and a second operation was successfully performed.  相似文献   
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Hibernomas are rare soft tissue tumors of brown fat differentiation. A case of a large axillary hibernoma, along with a review of its pathology, is presented. This tumor matches the largest hibernoma in the literature and is the largest in an axillary site.  相似文献   
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