全文获取类型
收费全文 | 505篇 |
免费 | 34篇 |
国内免费 | 2篇 |
专业分类
耳鼻咽喉 | 3篇 |
儿科学 | 13篇 |
妇产科学 | 12篇 |
基础医学 | 93篇 |
口腔科学 | 23篇 |
临床医学 | 30篇 |
内科学 | 147篇 |
皮肤病学 | 21篇 |
神经病学 | 25篇 |
特种医学 | 25篇 |
外科学 | 23篇 |
综合类 | 2篇 |
预防医学 | 21篇 |
眼科学 | 3篇 |
药学 | 57篇 |
中国医学 | 1篇 |
肿瘤学 | 42篇 |
出版年
2024年 | 1篇 |
2023年 | 8篇 |
2022年 | 20篇 |
2021年 | 32篇 |
2020年 | 20篇 |
2019年 | 26篇 |
2018年 | 26篇 |
2017年 | 14篇 |
2016年 | 18篇 |
2015年 | 10篇 |
2014年 | 28篇 |
2013年 | 21篇 |
2012年 | 30篇 |
2011年 | 32篇 |
2010年 | 21篇 |
2009年 | 13篇 |
2008年 | 36篇 |
2007年 | 23篇 |
2006年 | 29篇 |
2005年 | 37篇 |
2004年 | 19篇 |
2003年 | 18篇 |
2002年 | 18篇 |
2001年 | 2篇 |
2000年 | 6篇 |
1999年 | 3篇 |
1998年 | 3篇 |
1997年 | 2篇 |
1996年 | 3篇 |
1995年 | 3篇 |
1994年 | 2篇 |
1993年 | 1篇 |
1992年 | 4篇 |
1991年 | 4篇 |
1990年 | 1篇 |
1988年 | 1篇 |
1987年 | 1篇 |
1986年 | 1篇 |
1985年 | 1篇 |
1977年 | 1篇 |
1973年 | 2篇 |
排序方式: 共有541条查询结果,搜索用时 15 毫秒
1.
Toshihiro Kawamura Hiroshi Motoyama Atsushi Yanaihara Takeshi Yorimitsu Akane Arichi Yasuhiro Karasawa Kahori Suga Kaoru Miya Seika Ishikawa Shiho Mizushima Makiko Kawamura 《Reproductive Medicine and Biology》2007,6(1):53-57
Aim: To compare the clinical outcomes of cryopreserved-thawed embryo transfer among patients with a normal menstrual cycle who had natural or hormone-replacement cycles.
Methods: From January 2004 to June 2006, cryopreserved embryos following conventional in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) were thawed and transferred in a total of 720 natural cycles and 136 hormone-replacement cycles.
Results: Cryopreserved-thawed embryo transfer in patients who had a natural or hormone-replacement cycle resulted in clinical pregnancy in 43.1% and 40.4%, respectively; a rate of miscarriage of 14.5% and 23.6%, respectively; and a rate of ongoing pregnancy and delivery of 36.5% and 30.9%, respectively. None of these differences were statistically significant.
Conclusions: Patients with a normal menstrual cycle who have natural or hormone-replacement cycles can be expected to have comparable clinical outcomes with cryopreserved-thawed embryo transfer. (Reprod Med Biol 2007; 6 : 53–57) 相似文献
Methods: From January 2004 to June 2006, cryopreserved embryos following conventional in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) were thawed and transferred in a total of 720 natural cycles and 136 hormone-replacement cycles.
Results: Cryopreserved-thawed embryo transfer in patients who had a natural or hormone-replacement cycle resulted in clinical pregnancy in 43.1% and 40.4%, respectively; a rate of miscarriage of 14.5% and 23.6%, respectively; and a rate of ongoing pregnancy and delivery of 36.5% and 30.9%, respectively. None of these differences were statistically significant.
Conclusions: Patients with a normal menstrual cycle who have natural or hormone-replacement cycles can be expected to have comparable clinical outcomes with cryopreserved-thawed embryo transfer. (Reprod Med Biol 2007; 6 : 53–57) 相似文献
2.
Fumiki Oana Toshiki Homma Hiroo Takeda Akane Matsuzawa Satoshi Akahane Masayuki Isaji Masuo Akahane 《Pharmacological research》2005,52(5):395-400
We aimed to examine the effects of KTO-7924 (beta3-adrenoceptor agonist) on lipid metabolism and mRNA expressions in retroperitoneal white adipose tissue (RP WAT) in obese (fa/fa) Zucker rats using DNA microarray. Oral KTO-7924 for 28 days significantly decreased RP WAT weight, plasma triglyceride, free fatty acid, and insulin, and improved insulin resistance in oral glucose tolerance tests. In RP WAT of KTO-7924-treated rats, DNA microarray analysis revealed specifically enhanced mRNA expressions of uncoupling protein 1 (UCP1) and cytochrome c oxidase subunit VIII-H (COX8H), which are reportedly highly expressed in brown adipose tissue (BAT). Since these mRNA expression levels in RP WAT were significantly lower in obese (fa/fa) Zucker rats than in lean Zucker rats, these genes may be important in lipid metabolism. Our results imply that in obese (fa/fa) Zucker rats, continuous stimulation of beta3-adrenoceptors by KTO-7924 causes BAT-like adipocytes to appear in RP WAT, and improves lipid metabolism. 相似文献
3.
4.
Ide A Kawasaki E Abiru N Sun F Takahashi R Kuwahara H Fujita N Kita A Oshima K Sakamaki H Uotani S Yamasaki H Yamaguchi Y Eguchi K 《Human immunology》2002,63(8):690-695
This study investigated whether interleukin-10 (IL-10) gene promoter region polymorphisms are associated with susceptibility to or clinical presentation of type 1 diabetes. The frequency of -1082G/A, -819C/T, and -592C/A polymorphisms was analyzed in 128 Japanese patients with type 1 diabetes and in 107 healthy control subjects in a case-controlled study. The allelic and haplotypic frequencies of the IL-10 gene promoter region polymorphisms were similar in patients with type 1 diabetes and in control subjects. However, the -819T and -592A allele were associated with adult-onset (>18 years) of the disease (p = 0.037). Furthermore, the frequency of ATA haplotype was increased in adult-onset patients than that in early-onset patients (< or =18 years; p = 0.037). Among the genotypes comprising ATA haplotype, the frequency of ATA/ATA was significantly higher in adult-onset patients than in early-onset patients (p = 0.004). These results suggest that the IL-10 gene promoter polymorphisms are associated with the age-at-onset in Japanese patients with type 1 diabetes. 相似文献
5.
Ozasa K Higashi A Yamasaki M Hayashi K Watanabe Y 《Environmental health and preventive medicine》1997,2(2):85-88
Differences observed by comparing the responses to two surveys taken 5 years apart were compared with self-reported changes
in dietary habits in the second survey to examine the construct validity of dietary change. That is, when an observed difference
about a certain food was consistent with a self-reported change, these two methods seemed to show a high validity regarding
dietary change. Both surveys used the same self-administered food intake frequency questionnaire, and subjective changes in
food intake were evaluated at the second survey (self-reported change). Eight hundred fifty-five males and one thousand females
aged 30-69 years were analyzed. Since results by both methods showed a higher frequency of increased intake of green-yellow
vegetables in general, pale- colored vegetables in general, carrots, and squash, these results were thought to be of high
validity. However, cabbage, lettuce, and seaweeds showed inconsistent results regarding higher frequencies of intake. Changes
among quintiles of lower frequency seemed to show lower validity because the results obtained by the two methods were often
inconsistent for dairy foods and some other foods. Thus, self-reported changes may reflect respondents’ attitudes toward foods,
not their actual behavior. 相似文献
6.
7.
Kaori Kitaoka Azusa Kitade Junko Nagaoka Kokoro Tsuzaki Kiyomi Harada Wataru Aoi Sayori Wada Hiroaki Asano Naoki Sakane Akane Higashi 《Nutrition Research And Practice》2015,9(4):385-392
BACKGROUND/OBJECTIVESRecent studies have reported an association of the angiotensin II type 2 receptor (AT2R) 3123Cytosine/Adenine (3123C/A) polymorphism with essential hypertension and cardiovascular diseases. The purpose of the study was to investigate whether the AT2R 3123C/A polymorphism affects blood pressure for free-living hypertensive men during a 5-month intervention period.SUBJECTS/METHODSThe subjects were free-living hypertensive Japanese men aged 40 to 75 years who agreed to intervention in the period from 2004 to 2011. Detection of the AT2R 3123C/A polymorphism was determined by polymerase chain reaction. The dietary intervention was designed to decrease salt level and to increase potassium level through cooking instructions and self-monitoring of the diet. The exercise session consisted of activities such as stretching, resistance training, and walking. Blood pressure, urinary sodium and potassium excretion, dietary and lifestyle data, and non-fasting venous blood sample were collected at baseline and after the intervention period.RESULTSThirty nine subjects were eligible for participation and the follow-up rate was 97.4%. The C allele proportion was 57.9%. AT2R 3123C/A polymorphism was X-chromosome-linked, therefore we analyzed the C and A genotypes. At baseline, no significant differences were observed between the genotype groups. After the intervention, there were no significant differences in lifestyle habit between the groups. Nevertheless, the estimated salt excretion (g/day) was significantly decreased only in the C genotype (13.0-10.3, P = 0.031). No significant change was observed in systolic blood pressure (SBP) (mmHg) in the A genotype, but a significant decrease was observed in the C genotype (150.0-141.5, P = 0.024).CONCLUSTIONSIn the C genotype, it might be easy to improve SBP through lifestyle intervention in free-living hypertensive Japanese men, however generalization could not be achieved by the small sample size. 相似文献
8.
Yutaka Hatani Hidekazu Tanaka Akane Kajiura Daisuke Tsuda Yoichiro Matsuoka Hiroyuki Kawamori Fumitaka Soga Kensuke Matsumoto Takeshi Inoue Yutaka Okita Ken-ichi Hirata 《The Canadian journal of cardiology》2018,34(8):1088.e11-1088.e13
An 86-year-old man was admitted our hospital because of sudden onset of dyspnea after blunt chest trauma. Because his oxygen saturation deteriorated from 92% in the supine position to 86% in the sitting position, platypnea-orthodeoxia syndrome was suspected. Transesophageal echocardiography showed severe tricuspid regurgitation (TR) caused by anterior papillary muscle rupture. Furthermore, right-to-left shunt with TR through a patent foramen ovale (PFO) was observed. The diagnosis was therefore platypnea-orthodeoxia syndrome with right-to-left shunt through PFO with shunting exacerbated by acute severe TR after blunt chest trauma. The patient underwent urgent tricuspid valve repair and PFO closure and has remained asymptomatic postoperatively. 相似文献
9.
Akane Anai Kimiyo Ueda Koichi Harada Takahiko Katoh Kumiko Fukumoto Chang-Nian Wei 《Environmental health and preventive medicine》2015,20(6):447-454
Objectives
To assess the difference between self-reported and measured weight values in Japanese men and women and to determine the underlying determinants of the differences between self-reported and measured values.Methods
The data were collected from 363 general Japanese individuals aged 16–88 years living in Kumamoto prefecture. Participants completed a self-administered questionnaire designed for this study with self-reported weight and height values. Measured weight and height were measured immediately after questionnaire completion. Paired t-tests identified differences between self-reported and measured values by sex. Multiple-stepwise regression analysis examined the independent variables’ effects on the differences between self-reported and measured weights.Results
Significant differences were found between self-reported and measured values for both sexes (p < 0.001). There was a significant negative relationship between the difference in an individual’s self-reported and measured weight in each sex, with higher measured weight individuals more likely to underestimate their weight. Multiple-stepwise regression analysis models explained 12.1 % (p < 0.01), 11.3 % (p < 0.01), and 5.6 % (p < 0.01) of the variance in all participants, men, and women, respectively. Significant effects were found for age, weight measurement frequency, and measured weight in total participants, weight measurement frequency, and measured weight for men, and age for women.Conclusions
In this study, the mean absolute value of the weight and height variances proved the unreliability of self-reported weight and height values. This study’s findings suggest self-reported weight inaccuracy especially for obese populations. This should be adjusted when using it in epidemiological studies and healthcare planning.10.
Akane Hara Tomohiro Watanabe Kosuke Minaga Tomoe Yoshikawa Ken Kamata Masatoshi Kudo 《World journal of gastroenterology : WJG》2021,27(19):2257-2269
Solitary organ autoimmune disorders, formerly known as autoimmune pancreatitis (AIP), autoimmune sialadenitis, and autoimmune sclerosing cholangitis, are now considered organ-specific manifestations of systemic immunoglobulin G4-related disease (IgG4-RD). AIP and IgG4-RD are characterized by elevated serum concentration of IgG4 antibody (Ab), accumulation of IgG4-expressing plasmacytes in the affected organs, and involvement of multiple organs. It is well established that enhanced IgG4 Ab responses are a hallmark of AIP and IgG4-RD for diagnosis and monitoring disease activity. However, a significant fraction of patients with AIP and IgG4-RD who develop chronic fibroinflammatory responses have normal serum concentrations of this IgG subtype. In addition, disease flare-up is sometimes seen even in the presence of normalized serum concentrations of IgG4 Ab after successful induction of remission by prednisolone. Therefore, it is necessary to identify new biomarkers based on the understanding of the pathophysiology of AIP and IgG4-RD. Recently, we found that activation of plasmacytoid dendritic cells producing both interferon-α (IFN-α) and interleukin-33 (IL-33) mediate murine AIP and human IgG4-RD. More importantly, we provided evidence that serum concentrations of IFN-α and IL-33 could be useful biomarkers for the diagnosis and monitoring of AIP and IgG4-RD activity after induction of remission in these autoimmune disorders. In this Frontier article, we have summarized and discussed biomarkers of AIP and IgG4-RD, including Igs, autoAbs, and cytokines to provide useful information not only for clinicians but also for researchers. 相似文献