全文获取类型
收费全文 | 616篇 |
免费 | 8篇 |
专业分类
耳鼻咽喉 | 5篇 |
儿科学 | 15篇 |
妇产科学 | 4篇 |
基础医学 | 50篇 |
口腔科学 | 62篇 |
临床医学 | 47篇 |
内科学 | 71篇 |
皮肤病学 | 8篇 |
神经病学 | 18篇 |
特种医学 | 33篇 |
外科学 | 252篇 |
综合类 | 16篇 |
一般理论 | 1篇 |
预防医学 | 12篇 |
眼科学 | 5篇 |
药学 | 8篇 |
肿瘤学 | 17篇 |
出版年
2021年 | 4篇 |
2018年 | 10篇 |
2017年 | 6篇 |
2016年 | 4篇 |
2015年 | 13篇 |
2014年 | 21篇 |
2013年 | 45篇 |
2012年 | 34篇 |
2011年 | 31篇 |
2010年 | 26篇 |
2009年 | 13篇 |
2008年 | 25篇 |
2007年 | 12篇 |
2006年 | 25篇 |
2005年 | 15篇 |
2004年 | 17篇 |
2003年 | 14篇 |
2002年 | 16篇 |
2001年 | 31篇 |
2000年 | 8篇 |
1999年 | 21篇 |
1998年 | 10篇 |
1997年 | 17篇 |
1996年 | 4篇 |
1995年 | 9篇 |
1994年 | 6篇 |
1993年 | 8篇 |
1992年 | 8篇 |
1991年 | 5篇 |
1990年 | 9篇 |
1989年 | 6篇 |
1987年 | 4篇 |
1986年 | 7篇 |
1985年 | 4篇 |
1984年 | 4篇 |
1981年 | 3篇 |
1978年 | 5篇 |
1977年 | 11篇 |
1976年 | 13篇 |
1975年 | 12篇 |
1974年 | 10篇 |
1973年 | 11篇 |
1972年 | 12篇 |
1971年 | 8篇 |
1970年 | 11篇 |
1969年 | 4篇 |
1967年 | 3篇 |
1966年 | 4篇 |
1965年 | 3篇 |
1964年 | 3篇 |
排序方式: 共有624条查询结果,搜索用时 31 毫秒
1.
Abdülmuttalip Keser Murat Bozkurt Omer Faruk Taner Mithat Akan Omer Sens?z 《Nordisk plastikkirurgisk forening [and] Nordisk klubb for handkirurgi》2004,38(5):257-260
The various methods of prefabricating flaps include vascular induction through staged transfer; pretransfer delay, expansion, and grafting; the use of alloplastic materials; and tissue bioengineering. In this experimental study, vascular induction was used to provide an axial vascular pedicle to randomly nourished tissue. Twenty-six New Zealand rabbits, ages and weights ranging between 6 months-1 year and 1.5-3.5 kg, respectively, were used. The sex difference was not considered. The deep inferior epigastric artery and vein were used to carry blood and were placed into a segment of femur to prefabricate the bone. Four weeks later, the viability of the segment of bone prefabricated by new axial pedicle was shown by scintigraphic study, and the new axial pedicle was ready for free transfer. 相似文献
2.
Oscillatory motion of the normal cervical spinal cord 总被引:2,自引:0,他引:2
3.
4.
Findik S Akan H Baris S Atici AG Uzun O Erkan L 《Journal of Korean medical science》2005,20(2):316-318
Primary hemangiopericytoma of the rib is extremely rare and only a few cases have been reported. A 62-yr-old man presented with an aching chest pain and dyspnea. Thoracic computed tomography revealed a homogenous mass expanding the right seventh rib. A diagnosis of hemangiopericytoma was established by percutaneous needle biopsy. Preoperative embolization of the feeding vessels of the tumor was performed in order to prevent perioperative bleeding. There was no significant bleeding during the surgery, where complete resection of the tumor with 7th to 9th ribs with a surgical margin of 5 cm was performed. Postoperative course was uneventful and there has been no recurrence for thirteen months. To our knowledge, there has been no report to apply a preoperative embolization of a primary hemangiopericytoma of the rib. 相似文献
5.
Mutational analysis of the SOX9 gene in campomelic dysplasia and autosomal sex reversal: lack of genotype/phenotype correlations 总被引:9,自引:1,他引:9
Meyer J; Sudbeck P; Held M; Wagner T; Schmitz ML; Bricarelli FD; Eggermont E; Friedrich U; Haas OA; Kobelt A; Leroy JG; Van Maldergem L; Michel E; Mitulla B; Pfeiffer RA; Schinzel A; Schmidt H; Scherer G 《Human molecular genetics》1997,6(1):91-98
It has previously been shown that, in the heterozygous state, mutations in
the SOX9 gene cause campomelic dysplasia (CD) and the often associated
autosomal XY sex reversal. In 12 CD patients, 10 novel mutations and one
recurrent mutation were characterized in one SOX9 allele each, and in one
case, no mutation was found. Four missense mutations are all located within
the high mobility group (HMG) domain. They either reduce or abolish the
DNA-binding ability of the mutant SOX9 proteins. Among the five nonsense
and three frameshift mutations identified, two leave the C-terminal
transactivation (TA) domain encompassing residues 402-509 of SOX9 partly or
almost completely intact. When tested in cell transfection experiments, the
recurrent nonsense mutation Y440X, found in two patients who survived for
four and more than 9 years, respectively, exhibits some residual
transactivation ability. In contrast, a frameshift mutation extending the
protein by 70 residues at codon 507, found in a patient who died shortly
after birth, showed no transactivation. This is apparently due to
instability of the mutant SOX9 protein as demonstrated by Western blotting.
Amino acid substitutions and nonsense mutations are found in patients with
and without XY sex reversal, indicating that sex reversal in CD is subject
to variable penetrance. Finally, none of 18 female patients with XY gonadal
dysgenesis (Swyer syndrome) showed an altered SOX9 banding pattern in SSCP
assays, providing evidence that SOX9 mutations do not usually result in XY
sex reversal without skeletal malformations.
相似文献
6.
Mahmut C. Ergoren Gokce Akan Ender Volkan Emine Kandemis Emine U. Evren Hakan Evren Eliz Volkan Gulten Tuncel Kaya Suer Tamer Sanlidag 《Journal of medical virology》2023,95(1):e28309
There is a significant body of evidence showing that efficient vaccination schemes against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is helping control the coronavirus disease 2019 (COVID-19) pandemic. However, this goal cannot be achieved without real world data highlighting the impact of vaccines against viral spread. In this study, we have aimed at differentially investigating the impact of COVID-19 vaccines (CoronaVac, Pfizer/BioNTech, Astra/Zeneca Oxford, Janssen) used in North Cyprus in limiting the viral load of Delta and Omicron variants of SARS-COV-2. We have utilized real-time quantitative polymerase chain reaction cycle threshold values (Ct values) as a proxy of viral load of the two SARS-CoV-2 variants. Our results indicate that the administration of at least two doses of the messenger RNA-based Pfizer/BioNTech vaccine leads to the lowest viral load (highest Ct values) obtained for both Omicron and Delta variants. Interestingly, regardless of the vaccine type used, our study revealed that Delta variant produced significantly higher viral loads (lower Ct values) compared with the Omicron variant, where the latter was more commonly associated with younger patients. Viral spread is a crucial factor that can help determine the future of the pandemic. Thus, prioritizing vaccines that will play a role in not only preventing severe disease but also in limiting viral load and spread may contribute to infection control strategies. 相似文献
7.
8.
The Clinical Value of the Ratio of Free Prostate Specific Antigen to Total Prostate Specific Antigen
Objective: To examine the usefulness of the ratio of free prostate specific antigen (FPSA) to total prostate specific antigen (TPSA) in men with serum TPSA concentration of 4 to 10 ng/mL by using the cut off value of 0.15 for avoiding unnecessary biopsies.
Patients and methods: Two hundred thirty-six men aged between 52 and 91 with symptoms of prostatism were evaluated with digital rectal examination (DRE), FPSA and TPSA measurements. Patients with TPSA values under 4 ng/mL were biopsied if they had positive DRE and/or a FPSA/TPSA ratio lower than 0.15. All patients with TPSA values higher than 4 ng/mL were also biopsied. The predictive value and sensitivity of FPSA/TPSA ratio and TPSA alone were calculated.
Results: Eleven patients out of 170 with a TPSA value lower than 4 ng/mL were biopsied. Fifty-five patients had a value between 4.1 and 10 ng/mL. We performed transrectal ultrasound (TRUS) and prostate biopsy in these men except one patient. Biopsy proven prostate cancer was detected only in 12 patients. In this group of patients the predictive value of TPSA was 21%, but the predictive value of FPSA/TPSA ratio of 0.15 was 78% maintaining at least 90% sensitivity. Eleven of the patients had a prostate specific antigen (PSA) value higher than 10 ng/mL. In 6 of these patients the biopsy result was prostate cancer and 10 of these patients had a FPSA/TPSA ratio lower than 0.15.
Conclusion: In patients with TPSA values between 4–10 ng/mL the cut off value of FPSA/TPSA ratio of 0.15 can be used to eliminate unnecessary biopsies with minimal loss of cancer patients. 相似文献
9.
Effect of genetic modification of acute inflammatory responsiveness on tumorigenesis in the mouse 总被引:1,自引:3,他引:1
10.
This case report describes a rare complication of unicompartmental knee arthroplasty. Femoral fracture after TKR is a serious and relatively common problem, but to the best of our knowledge, only one case of femoral condylar fracture after UKA has been reported thus far. 相似文献