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beta2-Adrenergic signaling in human heart: shift from the cyclic AMP to the arachidonic acid pathway
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Peter D. Crompton Matthew A. Kayala Boubacar Traore Kassoum Kayentao Aissata Ongoiba Greta E. Weiss Douglas M. Molina Chad R. Burk Michael Waisberg Algis Jasinskas Xiaolin Tan Safiatou Doumbo Didier Doumtabe Younoussou Kone David L. Narum Xiaowu Liang Ogobara K. Doumbo Louis H. Miller Denise L. Doolan Pierre Baldi Philip L. Felgner Susan K. Pierce 《Proceedings of the National Academy of Sciences of the United States of America》2010,107(15):6958-6963
Abs are central to malaria immunity, which is only acquired after years of exposure to Plasmodium falciparum (Pf). Despite the enormous worldwide burden of malaria, the targets of protective Abs and the basis of their inefficient acquisition are unknown. Addressing these knowledge gaps could accelerate malaria vaccine development. To this end, we developed a protein microarray containing ∼23% of the Pf 5,400-protein proteome and used this array to probe plasma from 220 individuals between the ages of 2–10 years and 18–25 years in Mali before and after the 6-month malaria season. Episodes of malaria were detected by passive surveillance over the 8-month study period. Ab reactivity to Pf proteins rose dramatically in children during the malaria season; however, most of this response appeared to be short-lived based on cross-sectional analysis before the malaria season, which revealed only modest incremental increases in Ab reactivity with age. Ab reactivities to 49 Pf proteins measured before the malaria season were significantly higher in 8–10-year-old children who were infected with Pf during the malaria season but did not experience malaria (n = 12) vs. those who experienced malaria (n = 29). This analysis also provided insight into patterns of Ab reactivity against Pf proteins based on the life cycle stage at which proteins are expressed, subcellular location, and other proteomic features. This approach, if validated in larger studies and in other epidemiological settings, could prove to be a useful strategy for better understanding fundamental properties of the human immune response to Pf and for identifying previously undescribed vaccine targets. 相似文献
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Gustave Kouassi Koffi Aissata Tolo Danho Clotaire Nanho Emeraude N’dathz Mathias Yao Kouassi Fatou Diago N’Diaye Boidy Kouakou N’dogomo Meité Romeo Ayemou Mamadou Sekongo Paul Kouehion Mori Meité Norbert Dagnekpo Tea Amadou Sangaré Ibrahima Sanogo 《International journal of hematology》2010,91(5):838-843
African Burkitt lymphomas (BL) are highly aggressive lymphomas mainly affecting children and young adults in Africa. This lymphoma was marked by its high sensitivity to chemotherapy in comparison to Sporadic Burkitt lymphoma. In this study, we evaluated the treatment response and survival of patients with CMA protocol. Eighty-five of the 105 children registered were evaluated for response; there were 46 boys and 39 girls, whose age at diagnosis ranged from 3 to 18 years (median 11 years), admitted to the Hematology National Teaching Hospital of Abidjan in the period 1998–2008 with a diagnosis of BL on histological review and who were given CMA chemotherapy with curative intent are included in this analysis. CMA protocol is a low intermediate regimen of 3 drugs [Cytarabin (ara-C), Methotrexate (MTX), and Cyclophosphamide] with CNS-directed treatment by intrathecal MTX, ara-C and corticosteroid. Fifty-five of 85 patients obtained CR after induction therapy and 10 after 3 supplementary cycle because of partial response. The overall complete remission was 76%. Fifty-three of patients were alive in first CR at a median survival rate period of 2 years (range 82 days to 9 years) and are continuously disease free from Burkitt lymphomas. Twelve patients relapse after CR and died of lymphoma progression. More than 32 patients died, as a result of lymphoma progression. Among the 32 dead, 10 were in Murphy stage IV and all the patients who presented bone marrow involvement died. The projected 5-year overall survival rate was 62%. In conclusion, CMA protocol shows the high sensitivity of African Burkitt lymphoma. This can be considered as a successful result for people living in poor socio-economic conditions with no health insurance. 相似文献
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Background
China has been sending medical teams to Africa since 1963. Chinese Medical Teams (CMT) are currently working in 42 African countries, constituting a large component of Chinese health aid. Mali has been receiving teams on a continuous basis since 1968. From 2011 the team in Mali has been based in the Mali Hospital in Bamako. This hospital was built with Chinese Government aid. The aim of this study was to observe how the CMT functioned, how their role was perceived, and to assess their utility for the hospital and its patients.Methods
The study was carried out from January to March 2018. In-depth interviews were carried out with 12 Malian doctors and 12 nurses, all the members of the CMT (except support staff), as well as four key stakeholders and ten patients. Interviews explored views about the role of the Chinese team in the hospital, the pros and cons of the collaboration, and suggestions for improvement. CMT members were also asked about their motivation to work in Mali and how they managed the lifestyle. All interviews were carried out in private areas within the hospital. We recorded ethnographic observations of the hospital with a focus on relationships between Malian and Chinese staff, and general standards of care.Findings
At the time of the study the CMT had 25 members, 18 doctors and technicians, plus support staff (cooks, translators), all living in the hospital grounds. Most of the CMT members interviewed identified similar problems, which included: lack of agreed objectives for the team members (in particular their roles as teachers or members of staff), the language barrier between Malian and Chinese staff, difficulty attracting team members, lack of representation of the CMT on the hospital management committee, and very limited social engagement between Chinese and Malian staff. However, the Malian doctors and key stakeholders viewed the CMT as a very positive presence, improving overall clinical standards and ensuring the hospital's reputation as among the best public hospitals in the country.Interpretation
Our findings indicate that there needs to be a formal evaluation of the CMT programme in Mali and in other countries in Africa, to maximise utility and meet contemporary needs. This is especially relevant as the Chinese Government embarks on including global health as part of the Belt and Road initiative.Funding
Global Health Centre of Zhejiang University. 相似文献7.
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Laure Alexandre-Heymann Marie Dubert Dapa A. Diallo Saliou Diop Aissata Tolo Suzanne Belinga Ibrahima Sanogo Ibrahima Diagne Guillaume Wamba Kouakou Boidy Indou Deme Ly Ismaël Kamara Youssouf Traore Lucile Offredo Xavier Jouven Brigitte Ranque 《British journal of haematology》2019,184(2):253-262
Growth failure (GF) in children with sickle cell disease (SCD) tends to decline in high-income countries, but data are lacking in sub-Saharan Africa. We performed a cross-sectional study nested in the CADRE (Cœur, Artères et DREpanocytose) cohort in Mali, Senegal, Cameroon, Gabon and the Ivory Coast. SCD patients and healthy controls aged 5–21 years old were recruited (n = 2583). Frequency of GF, defined as a height, weight or body mass index below the 5th percentile on World health Organization growth charts, was calculated. We assessed associations between GF and SCD phenotypic group, clinical and biological characteristics and history of SCD-related complications. GF was diagnosed in 51% of HbSS, 58% of HbSβ0, 44% of HbSC, 38% of HbSβ+ patients and 32% of controls. GF in patients was positively associated with parents’ lower education level, male sex, age 12–14 years, lower blood pressure, HbSS or HbSβ0 phenotypes, icterus, lower haemoglobin level, higher leucocyte count and microalbuminuria. No association was found between GF and clinical SCD-related complications. In sub-Saharan Africa, GF is still frequent in children with SCD, especially in males and during adolescence. GF is associated with haemolysis and microalbuminuria, but not with the history of SCD-related clinical complications. 相似文献
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Dean Sayre Alioune Camara Yaya Barry Tour Babacar Deen Denka Camara Mohamed Dioubat Ibrahima Camara Kalil Keita Nouman Diakit Youssoufa Lo Ibrahima Bah Hadja Fanta Camara Mohamed Saran Cond Aissata Fofana Abdoulaye Sarr Eugne Lama Seth Irish Mateusz Plucinski 《Emerging infectious diseases》2021,27(2):599
Malaria incidence is generally lower in cities than rural areas. However, reported urban malaria incidence may not accurately reflect the level of ongoing transmission, which has potentially large implications for prevention efforts. To guide mosquito net distribution, we assessed the extent of malaria transmission in Conakry, Guinea, in 2018. We found evidence of active malaria transmission. 相似文献