全文获取类型
收费全文 | 1052篇 |
免费 | 109篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 5篇 |
儿科学 | 15篇 |
妇产科学 | 85篇 |
基础医学 | 161篇 |
口腔科学 | 46篇 |
临床医学 | 148篇 |
内科学 | 172篇 |
皮肤病学 | 8篇 |
神经病学 | 102篇 |
特种医学 | 72篇 |
外科学 | 104篇 |
综合类 | 42篇 |
预防医学 | 85篇 |
眼科学 | 23篇 |
药学 | 48篇 |
肿瘤学 | 46篇 |
出版年
2023年 | 13篇 |
2022年 | 7篇 |
2021年 | 17篇 |
2020年 | 17篇 |
2019年 | 33篇 |
2018年 | 21篇 |
2017年 | 20篇 |
2016年 | 22篇 |
2015年 | 12篇 |
2014年 | 20篇 |
2013年 | 37篇 |
2012年 | 83篇 |
2011年 | 68篇 |
2010年 | 41篇 |
2009年 | 24篇 |
2008年 | 38篇 |
2007年 | 65篇 |
2006年 | 46篇 |
2005年 | 36篇 |
2004年 | 37篇 |
2003年 | 43篇 |
2002年 | 32篇 |
2001年 | 21篇 |
2000年 | 42篇 |
1999年 | 26篇 |
1998年 | 19篇 |
1997年 | 15篇 |
1996年 | 13篇 |
1995年 | 10篇 |
1994年 | 10篇 |
1993年 | 8篇 |
1992年 | 24篇 |
1991年 | 22篇 |
1990年 | 28篇 |
1989年 | 25篇 |
1988年 | 16篇 |
1987年 | 12篇 |
1986年 | 17篇 |
1985年 | 22篇 |
1984年 | 10篇 |
1983年 | 12篇 |
1982年 | 6篇 |
1981年 | 8篇 |
1980年 | 7篇 |
1977年 | 5篇 |
1976年 | 6篇 |
1972年 | 7篇 |
1971年 | 8篇 |
1970年 | 4篇 |
1967年 | 4篇 |
排序方式: 共有1162条查询结果,搜索用时 14 毫秒
1.
Presentations of acute appendicitis represent an ongoing challenge to surgeons. This case of retrocaecal perforated appendicitis presented clinically as a right lumbar abscess, with the concomitant new diagnosis of type 2 diabetes mellitus in a 66-year-old male. This case emphasises the importance of an abdominal CT scan in any patient presenting with unusual sepsis near the abdomen. 相似文献
2.
Association of Hypoalbuminemia on the First Postoperative Day and Complications Following Esophagectomy 总被引:1,自引:0,他引:1
Aoife M. Ryan Aine Hearty Ruth S. Prichard Aileen Cunningham Suzanne P. Rowley John V. Reynolds 《Journal of gastrointestinal surgery》2007,11(10):1355-1360
Objective Changes in serum albumin may reflect systemic immunoinflammation and hypermetabolism in response to insults such as trauma
and sepsis. Esophagectomy is associated with a major metabolic stress, and the aim of this study was to determine if the absolute
albumin level on the first postoperative day was of value in predicting in-hospital complications.
Methods A retrospective study of 200 patients undergoing esophagectomy for malignant disease at St. James Hospital between 1999 and
2005 was performed. Patients who had pre and postoperative (days 1, 3, and 7) serum albumin levels measured were included
in the study. Patients were subdivided into three postoperative albumin categories <20 g/l, 20–25 g/l, >25 g/l. Logistic regression
analysis was performed to calculate the odds of morbidity and mortality according to the day 1 albumin level.
Results Patients with an albumin of less than 20 g/l on the first postoperative day were twice as likely to develop postoperative
complications than those with an albumin of greater than 20 g/l (54 vs 28% respectively, p < 0.011). Correspondingly, these patients also had a significantly higher rate of Adult Respiratory Distress Syndrome (22
vs 5%, p < 0.001), respiratory failure (27 vs 8%, p < 0.01) and in-hospital mortality (27 vs 6% (p < 0.001). On multivariate logistic regression analysis, day 1 albumin level was independently related to postoperative complications
(odds ratios, 0.89: 95%; confidence intervals, 0.83–0.96; p < 0.005). In addition, albumin <20 g/l on the first postoperative day was associated with the need for further surgery and
a return to ICU.
Conclusion Serum albumin concentration on the first postoperative day is a better predictor of surgical outcome than many other preoperative
risk factors. It is a low cost test that may be used as a prognostic tool to detect the risk of adverse surgical outcomes. 相似文献
3.
Double vulva. A case report 总被引:1,自引:0,他引:1
J Fanning 《The Journal of reproductive medicine》1987,32(4):297-300
Double vulva is an extremely rare congenital malformation; there are only 17 previously reported cases in the world literature. The syndrome usually consists of complete or partial duplication of the vulva, vagina, uterus, urethra, bladder and colon, with normal ovaries and kidneys and associated congenital malformations, especially of the lumbar spine. The etiology is uncertain. Mortality in the 18 cases reviewed was 35%. Diagnostic evaluation should include a careful newborn physical examination for associated congenital malformations, especially congenital heart disease, along with a radiologic survey of the lumbar spine, gastrointestinal tract and urinary system. No gynecologic surgical treatment is needed except for cosmetic reasons. 相似文献
4.
5.
R A Coates V T Farewell J Raboud S E Read M Klein D K MacFadden L M Calzavara J K Johnson M M Fanning F A Shepherd 《Journal of clinical epidemiology》1992,45(3):245-253
The Toronto Sexual Contact Study comprises a cohort of 249 male sexual contacts of men with HIV disease which has been followed every 3 months for almost 5 years. On enrollment 143 were seropositive and 16 seroconverted during the follow-up period. By 31 December 1989, 41 of the 159 seropositive cohort members had developed AIDS. Using Cox relative risk regression models, we investigated the association of a number of laboratory and clinical variables and progression to AIDS. Fixed covariate models examined laboratory variables from the enrollment visit of cohort members, with time calculated from this date. In models assessing time dependent covariates, time was calculated from the estimated date of HIV infection. In the univariate models of either fixed or time dependent covariates, many variables were significantly associated with risk of progression to AIDS (T4 cell count, T4/T8 ratio, blastogenic responses to phytohemagglutinin, concanavalin A, and pokeweed mitogen, serum IgA, appearance of p24 antigen, and the development of oral hairy leukoplakia, thrush, or herpes zoster). Appearance of persistent generalized lymphadenopathy was not associated with increased risk of progression. In the multivariate model which evaluated fixed laboratory covariates, T4/T8 ratio, IgA level, and PHA response at enrollment were significantly associated with elevated risk.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
6.
Nancy P. Caraway Gregg A. Staerkel Christina V. Fanning Datla G. Varma Raphael E. Pollock 《Diagnostic cytopathology》1994,11(3):255-261
The gross and microscopic appearances of aspirates from ten intramuscular myxomas are reported. The specimens were obtained from seven women and three men, ages 43 to 75, who had tumors involving the muscles of the thigh (7), upper arm (2), and forearm (1). Magnetic resonance (MR) imaging performed in six of the ten cases revealed well-defined, sharply demarcated tumors exhibiting low signal intensity relative to muscle on the T1-weighted images. The tumors were hyperintense to muscle on T2-weighted images. All aspirated tissues were clear, tenacious, and viscous. Smears contained few spindled and histiocytoid cells in an abundant mucoid background. Spindle cells demonstrated long cytoplasmic processes that in areas intertwined to form fibrillar tangles. Nuclei were oval to spindled with fine chromatin and inconspicuous nucleoli. Capillaries were sparse with simple (nonplexiform) branching. The differential diagnosis of myxoid lesions of the extremities includes benign entities such as myxoid schwannoma and neurofibroma, mesenchymal repair, and ganglion cyst, as well as malignant neoplasms such as myxoid liposarcoma, fibrosarcoma, malignant fibrous histiocytoma, and extraskeletal chondrosarcoma. The findings of this study revealed that, although the cytologic features were suggestive of intramuscular myxoma, a definitive diagnosis was often difficult, owing to scant cellularity and lack of distinctive cytologic features. The MR imaging findings may be utilized as an adjunct to the cytologic features to more confidently suggest a diagnosis of intramuscular myxoma. Diagn Cytopathol 1994;11:255–261. © 1994 Wiley-Liss, Inc. 相似文献
7.
8.
9.
10.
The SV40 large T antigen provides a helper function that permits human adenovirus yields in monkey cells to approach those obtained in human cells. The carboxy-terminus of large T antigen is involved in providing this activity. The ability of a large number of SV40 mutants affecting T antigen to enhance the growth of adenovirus type 2 in the CV-1 line of African green monkey kidney cells was examined. Mutation of those serines and threonines at the carboxy terminus which are normally phosphorylated had no effect on adenovirus helper function. A cytoplasmic T antigen was very effective in providing adenovirus helper function. Mutants that produce unstable T antigens provided helper function, but to a reduced degree. Finally, mutations in T antigen which permit it to interfere trans-dominantly with replication catalyzed by wildtype T antigen provided adenovirus helper function at wildtype levels. 相似文献