全文获取类型
收费全文 | 2288篇 |
免费 | 199篇 |
国内免费 | 31篇 |
专业分类
耳鼻咽喉 | 32篇 |
儿科学 | 48篇 |
妇产科学 | 49篇 |
基础医学 | 311篇 |
口腔科学 | 63篇 |
临床医学 | 230篇 |
内科学 | 474篇 |
皮肤病学 | 72篇 |
神经病学 | 103篇 |
特种医学 | 88篇 |
外国民族医学 | 2篇 |
外科学 | 498篇 |
综合类 | 39篇 |
一般理论 | 1篇 |
预防医学 | 193篇 |
眼科学 | 30篇 |
药学 | 128篇 |
中国医学 | 8篇 |
肿瘤学 | 149篇 |
出版年
2023年 | 20篇 |
2022年 | 51篇 |
2021年 | 73篇 |
2020年 | 50篇 |
2019年 | 81篇 |
2018年 | 121篇 |
2017年 | 71篇 |
2016年 | 78篇 |
2015年 | 75篇 |
2014年 | 110篇 |
2013年 | 120篇 |
2012年 | 159篇 |
2011年 | 168篇 |
2010年 | 116篇 |
2009年 | 88篇 |
2008年 | 116篇 |
2007年 | 129篇 |
2006年 | 113篇 |
2005年 | 123篇 |
2004年 | 84篇 |
2003年 | 87篇 |
2002年 | 78篇 |
2001年 | 59篇 |
2000年 | 59篇 |
1999年 | 38篇 |
1998年 | 17篇 |
1997年 | 15篇 |
1996年 | 16篇 |
1995年 | 10篇 |
1994年 | 10篇 |
1993年 | 8篇 |
1992年 | 24篇 |
1991年 | 12篇 |
1990年 | 12篇 |
1989年 | 16篇 |
1988年 | 17篇 |
1987年 | 9篇 |
1986年 | 11篇 |
1985年 | 9篇 |
1984年 | 6篇 |
1983年 | 5篇 |
1981年 | 3篇 |
1979年 | 9篇 |
1978年 | 5篇 |
1977年 | 3篇 |
1976年 | 6篇 |
1974年 | 5篇 |
1973年 | 3篇 |
1972年 | 3篇 |
1969年 | 4篇 |
排序方式: 共有2518条查询结果,搜索用时 15 毫秒
1.
2.
A G Assounga S Bascoul B Canaud P A Bouya J P Vendrell J P Sciolla G Mourad P Baldet A Serre C Mion 《American journal of kidney diseases》1990,15(6):556-561
This study reports on beta 2-microglobulin (beta 2M) deposits in the skin of 12 uremic patients and three kidney transplant recipients compared with eight healthy controls. Uremic patients were treated by hemodialysis (HD), hemofiltration (HF), hemodiafiltration (HDF), or continuous ambulatory peritoneal dialysis (CAPD) for a period lasting from 1 to 19 years. Congo red staining of the skin was negative in patients and controls. However, immunofluorescent staining with an anti-beta 2-microglobulin monoclonal antibody was positive in the skin of all patients and of six of the eight controls. Beta 2M skin deposition is more intense in patients than in controls and increases with patient age and the duration of dialysis. A stron correlation is observed between the extent of skin beta 2M deposits and clinical manifestations due to beta 2M deposits in internal organs. However, no correlation is found between beta 2M skin deposits and sex or beta 2M serum levels. 相似文献
3.
J. Hucke R. L. Campo F. De Bruyne A. Abou Freikha 《Archives of gynecology and obstetrics》1993,254(1-4):421-423
Ohne Zusammenfassung 相似文献
4.
5.
Abdelfettah Abid Raouf Denguir Karim Kaouel Mourad Hakim Imed Khanfir Taoufik Kalfat Adel Khayati 《La Tunisie médicale》2003,81(1):67-71
The aim of this study is to raise up the effect of surgical thrombectomy among other alternative therapies. This retrospective study reports 6 patients (mean age 63 years) admitted with phlegmasia cerulea dolens. All patients underwent surgical venous thrombectomy associated with infracava filter insertion in 2 cases. One patient died in the early postoperative course. In all other cases we noticed good early and late outcome both on clinical examination and duplex scanning assessment. In conclusion, surgical venous thrombectomy can be considered as a good and efficient procedure in the presence of phlegmasia cerulea dolens in order to relieve ischemia and to prevent whenever possible severe chronic venous disorders. However, fibrinolytic therapy might achieve as good results as surgery. Thus, the latter is to be reserved to very severe veinous ischemia with limb loss threatening where fibrinolytic therapy fails or is contre-indicated. 相似文献
6.
V. Haufroid P. Wallemacq V. VanKerckhove L. Elens M. De Meyer D. C. Eddour J. Malaise D. Lison M. Mourad 《American journal of transplantation》2006,6(11):2706-2713
Genetic polymorphisms in biotransformation enzyme CYP3A5 (6986G > A, CYP3A5*3; 14690A > G, CYP3A5*6) and drug transporter ABCB1 (1236C > T; 2677G > T/A; 3435C > T) are known to influence tacrolimus (Tac) dose requirements and trough blood levels in stable transplant patients. In a group of 19 volunteers selected with relevant genotypes among a list of 221 adult renal transplant candidates, we evaluated whether consideration of CYP3A5 and ABCB1 genetic polymorphisms could explain the interindividual variability in Tac pharmacokinetics after the first administration of a standard dose (0.1 mg/kg body weight twice a day). Lower area under the time versus blood concentration curves (AUC) or lower trough concentrations were observed among CYP3A5 expressors (n = 9) than among nonexpressors (n = 10) using two different analytical methods for Tac determination (liquid chromatography with tandem mass spectrometry (LC-MS/MS) and immunoassay). The median AUC(0-infinity) was 2.6- and 2.1-fold higher in nonexpressors for LC-MS/MS and immunologic methods, respectively. No difference was observed in Tac pharmacokinetic parameters in relation to ABCB1 polymorphisms. In conclusion, our study confirms the very significant effect of CYP3A5 polymorphism early after the first administration of Tac. It also provides a strong argument for a doubling of the loading dose in patients early identified a priori on the transplantation list as possessing at least one CYP3A5*1 allele. 相似文献
7.
M A el-Barrawy S A Hafez S A Mokhtar M A Abou Rayan 《The Journal of the Egyptian Public Health Association》1991,66(1-2):279-289
This study evaluates the sensitivity and specificity of an enzyme-linked immunosorbent assay (ELISA) for the detection of antibodies against Mycobacterium tuberculosis antigen. Twenty seven of the 35 patients with pulmonary tuberculosis had positive serology with an antibody titre of 10 nineteen of them had positive serology with an antibody titre of 100. All the 27 patients with positive serology were either smear or culture positive or both. Twenty six of the 35 control group had negative serology and 9 had positive serology with an antibody titre of 10. The test has a sensitivity of 77.14% and a specificity of 74.29%. 相似文献
8.
A N Nasi A M Mangoud M I Assaf M I Abou Zeid M M Azab 《The Journal of the Egyptian Public Health Association》1992,67(5-6):685-695
Serum samples were collected from 40 patients with enlarged lymph nodes. Lymph node and bone marrow biopsies were performed and processed as usual. Tumor necrosis factor-alpha (TNF alpha) was determined in the sera by factor test human TNF alpha ELISA kit. Histopathological studies of lymph node and bone marrow biopsies were evaluated. The data obtained from this study showed that bone marrow was involved in only 5 patients and their TNF showed the lowest level in this study with a mean level 50 pg/ml. The highest level of TNF occurred in cases with granulomatous lymphadenitis (124 pg/ml) followed by reactive lymphadenitis (105 pg/ml). It can be considered that TNF reflects the immune status of the patient and its study in the serum can be of help in evaluating the progress of the disease. An extended study is need to evaluate the role of TNF-alpha as a prognostic marker in malignancy. 相似文献
9.
10.