Percutaneous Mitral Commissurotomy in Acute Pulmonary Edema

From January 1994 to July 1998, percutaneous mitral commissurotomy was performed in 520 patients. Of these patients, 7 (4 men and 3 women aged 31 ± 5.6 years) were dilated in an emergency situation of intractable pulmonary edema caused by severe mitral stenosis. Three patients required mechanical ventilatory support. Percutaneous mitral commissurotomy was performed with the Inoue balloon. The dilatation of the valve was undertaken even though the echocardiographic score of the valve was high. Percutaneous mitral commissurotomy resulted in an increase in the mitral valve area from 0.72 ± 0.18 cm² to 1.95 ± 0.18 cm² (P = 0.011) with a concomitant reduction in pulmonary artery systolic pressure from 82.5 ± 16.4 mmHg to 46.7 ± 11.6 mmHg (P = 0.018). One patient died (he had two cardiac arrests before the dilatation). During follow-up (mean 18 months), one patient presented with a restenosis, one an aggravation of mitral insuflciency grade, and four were in NYHA functional Class II. Thus, percutaneous mitral commissurotomy can be considered as a treatment of choice in patients with intractable pulmonary edema caused by severe mitral stenosis.     

阴道用中药原位凝胶的研究进展

原位凝胶是一类以溶液状态给药后,能在用药部位立即发生相转变,由液态转化形成非化学交联半固体凝胶的制剂。其具有溶液和凝胶的双重优势,已成为药剂学研究的热点。传统的阴道给药剂型存在滞留时间短、生物利用度低等问题,近年来已有较多研究将新型原位凝胶应用于阴道给药,通过延长阴道内滞留时间来提高药物的生物利用度。中药原位凝胶有利于其药效的提升,通过参阅近年来国内外相关文献,从阴道用中药原位凝胶剂的特点、分类、制备和评价方法等方面进行综述,以期为阴道用中药原位凝胶剂的进一步研究与应用提供依据。     

Percutaneous embolization of persistent urinary fistula after partial nephrectomy using N-butyl-2-cyanoacrylate

Percutaneous closure of a calyceal fistula following partial nephrectomy for kidney cancer was achieved with fistula embolization with n-butyl-2-cyanoacrylate. Previous attempts at closure by conservative and endoscopic means were unsuccessful. Tissue adhesives are useful in the management of persistent urinary leakage after partial nephrectomy.     

基于“药物-成分-靶点”探讨中药复方辨证论治阴道炎的科学内涵

阴道炎是目前常见的妇科疾病之一，具有发病率、复发率相对较高的特点。中药复方治疗阴道炎疗效突出、复发率较低，然而其治疗阴道炎的机制复杂，成分、靶点间关系尚不清楚。通过从中、西医角度对阴道炎病因、病机、治则进行对比，对中药复方辨证论治阴道炎的研究进展进行综述，并通过网络药理学对清热利湿、健脾利湿、滋阴补肾型中药复方治疗阴道炎的成分、靶点进行收集，说明中医辨证论治的治疗特点，解释了中医分证型治疗阴道炎的合理性，为中药复方治疗阴道炎的潜在药物发现及临床精准治疗提供参考。