黄芩茎叶总黄酮对高脂血症兔主动脉VCAM-1、ICAM-1表达的影响

目的观察黄芩茎叶总黄酮(SSTF)对高脂血症兔主动脉血管细胞黏附分子(VCAM)-1、细胞间黏附分子(ICAM)-1表达的影响,探讨SSTF抗动脉粥样硬化(AS)的可能机制。方法 24只健康雄性家兔随机分为正常对照组(6只),喂养普通饲料,动脉粥样硬化模型组(18只),喂养高脂饲料。8w后,将AS模型组再随机分为模型组,继续喂养高脂饲料,SSTF治疗组,喂养高脂饲料并灌胃给予SSTF(100、200mg·kg-1.d-1),治疗4w后,处死家兔,测定各组家兔TC、TG、LDL-C,取主动脉做病理切片,免疫组化检测主动脉VCAM-1、ICAM-1的表达。结果 SSTF可以降低高脂饮食兔血清TC、TG、LDL-C水平,作用效果呈剂量依赖性。SSTF能够逆转动脉粥样程度、抑制VCAM-1、ICAM-1的表达。结论 SSTF具有抗AS作用,可能与通过下调VCAM-1、ICAM-1表达,从而抑制血管壁炎症反应有关。     

天枢超声中药透入治疗阿片类所致肝郁脾虚型便秘的临床观察

ObjectivesTo observe the clinical effect on opioid-induced constipation of liver stagnation and spleen deficiency treated with the ultrasonic penetration of the No.1 constipation herbal formula at Tiānshū (天枢 ST25).MethodsA total of 126 patients that were in compliance with the inclusion criteria were randomized into an acupoint group (41 cases), a Chinese medication group (42 cases) and a western medication group (43 cases). In the acupoint group, the ultrasonic penetration of the No.1 constipation herbal formula at bilateral Tiānshū (天枢 ST25) were given. In the Chinese herbal medication group, the No.1 constipation herbal formula was prescribed for oral administration. In the western medication group, polyethylene glycol electrolyte powder was prescribed for oral administration. The treatment was given once a day, for 14 days totally. Before and after treatment, the constipation symptom score, the score of the patient assessment of constipation quality of life (PAC-QOL), the situation of nitric oxide synthetase (NOS) in serum were observed in each group. The safety indicators in the observation included diarrhea, allergic reaction, liver dysfunction, skin lesions, etc.ResultsA total of 122 cases accomplished the trial. The total effective rate was 82.5% in the acupoint group, 80.48% in the Chinese medication group and 78.04% in the western medication group. The constipation symptoms were all relieved in the three groups, indicating the statistical significance as compared with those before treatment (P < 0.01, P < 0.05). In the acupoint group and the western medication group, the improvements in the three symptom items, i.e. distention or scurrying pain in the chest, hypochondriac region or the bilateral sides of the abdomen, depression or irritability and poor appetite, were better than the western medication group (P < 0.01, P < 0.05). The improvements in all of the symptoms in the acupoint group were better than the Chinese medication group (all P < 0.05). The PAC-QOL score was improved in each group after treatment and it was different significantly in statistics as compared with that before treatment in each group. After treatment, the improvement of PAC-QOL score in the acupoint group and the Chinese medication group was better than that in the western medication group (both P < 0.05), and the improvement in the acupoint group was better than the Chinese medication group (P < 0.05). As to serum NOS, after treatment, it was different significantly as compared with that before treatment in each group (all P < 0.05), the improvement in the acupoint group was better than that of either the Chinese medication group or the western medication group, indicating the statistical significance (both P < 0.05). The incidence of adverse reaction in the acupoint group was less and different significantly as compared with the western medication group (P < 0.01), and it was different statistically as compared with the Chinese medication group (P < 0.05).ConclusionThe ultrasonic penetration of the No.1 constipation herbal formula at Tiānshū (天枢 ST25) is effective on opioid-induced constipation of liver stagnation and spleen deficiency. This therapy achieves the significant therapeutic effect and presents the good compliance in treatment. Hence, it deserves to be further promoted in clinical application.     

100例新癀片联合黄马酊和槐花蜂蜜治疗急性痛风性关节炎临床观察

目的 观察新癀片联合黄马酊和槐花蜂蜜外敷患处治疗急性痛风性关节炎的临床疗效.方法 将100 例患者随机分为对照组和治疗组各50例,均采用常规治疗,治疗组在此基础上加用新癀片联合黄马酊和槐花蜂蜜 持续外敷患处,两组在治疗1周后观察疗效.结果 治疗组在缓解肿胀程度、疼痛指数及C反应蛋白(CRP)等方面 均优于对照组,治疗组有效率为94.00%,差异有统计学意义(P<0.05).结论 在常规治疗的基础上,新癀片联 合黄马酊和槐花蜂蜜外敷治疗急性痛风性关节炎能明显缓解疼痛,改善急性痛风性关节炎的效果.