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罗格列酮对2型糖尿病合并颈动脉粥样硬化患者血清基质金属蛋白酶-9及C-反应蛋白的影响 总被引:2,自引:0,他引:2
目的探讨罗格列酮(Rosiglitazone)的抗炎、抗动脉粥样硬化(AS)作用及其机制。方法应用彩色多普勒超声测量颈动脉内中膜厚度(IMT)及斑块情况以判定颈动脉粥样硬化,将2型糖尿病颈动脉粥样硬化患者随机分为罗格列酮治疗组和非罗格列酮治疗组。采用酶联免疫吸附(ELISA)法测定血清基质金属蛋白酶-9(MMP-9)、C-反应蛋白(CRP)水平,观察罗格列酮治疗前后MMP-9、CRP水平变化及与非罗格列酮治疗组之间变化的差别。结果应用罗格列酮治疗组治疗2周时的血清MMP-9、CRP水平分别为[397.3(282.4~600.9)]μg/L、[3.54(1.68~8.48)]mg/L,较治疗前水平[600.3(467.1~836.2)]μg/L、[5.98(3.90~10.92)]mg/L明显下降,且较非罗格列酮治疗组下降更加明显,而空腹血糖(FPG)在两治疗组间无显著性差异。罗格列酮治疗12周时的血清MMP-9、CRP水平较治疗2周时明显下降,分别为[259.3(136.0~495.2)]μg/L,[1.71(1.01~4.63)]mg/L。结论罗格列酮具有抗炎及独立于降糖之外的抗AS作用,且在一定时期内具有时间依赖性。 相似文献
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Objective To investigate the effect of IFN-α therapy for HBeAg-negative ehronie hepatitis B(CHB). Methods 50 cases of HBeAg-negative CHB patients were selected as treated group, while 52 cases of HBeAg-positive CHB as control group. Both groups received injection of IFN-α at dose of 6 MU every other day for 48 weeks. Levels of alanine aminotransferase, viral markers levels of HBeAg, HBV DNA and the four serum fibrosis markers were analysed before and after treatment and 24 weeks after the course. Results There were 36 cases in treated group and 26 cases in control group who had got obvious therapeutic effects at the end of 24 weeks after treatment. And the rates of efficacy were 72% and 50% separately. The rate of treated group was higher than that of control group(X2 = 5.43, P <0.05). The four serum fibrosis markers of the both groups were clearly dropped after treatment (t = 2.365, P < 0.05). Conclusions The theraputie effects of IFN-α at dose of 6 MU for HBeAg-negative CHB is prior to HBeAg-positive CHB. And IFN-α also have an evident funtion on preventing or delaying hepatic fibrosis in patients with CHB. 相似文献
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Objective To investigate the effect of IFN-α therapy for HBeAg-negative ehronie hepatitis B(CHB). Methods 50 cases of HBeAg-negative CHB patients were selected as treated group, while 52 cases of HBeAg-positive CHB as control group. Both groups received injection of IFN-α at dose of 6 MU every other day for 48 weeks. Levels of alanine aminotransferase, viral markers levels of HBeAg, HBV DNA and the four serum fibrosis markers were analysed before and after treatment and 24 weeks after the course. Results There were 36 cases in treated group and 26 cases in control group who had got obvious therapeutic effects at the end of 24 weeks after treatment. And the rates of efficacy were 72% and 50% separately. The rate of treated group was higher than that of control group(X2 = 5.43, P <0.05). The four serum fibrosis markers of the both groups were clearly dropped after treatment (t = 2.365, P < 0.05). Conclusions The theraputie effects of IFN-α at dose of 6 MU for HBeAg-negative CHB is prior to HBeAg-positive CHB. And IFN-α also have an evident funtion on preventing or delaying hepatic fibrosis in patients with CHB. 相似文献
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INTRODUCTION
Allergic granulomatous vaseulitis is a rare kind of systemic vascular disease which belongs to rheumatic vasculitis and invade small artery and vein. This disease was first reported by Racherann and Greene in 1939 and Churg and Strauss clarified the relation between pathology of this disease and clinic in 1951.8 cases were reported by Ma Jiliang in 1994 among which, 6 cases conformed to diagnosis of this disease and 2 cases were diagnosed by biopsy. 相似文献
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0 引言 腕管综合征是最常见的神经嵌压症,电生理检查可为临床及手术提供可靠的诊断依据。1 材料和方法1.1材料 1998年以来本院门诊、手外科及神经内科收治的60例腕管综合征的电生理检查患者,男18例,女42例,年龄29-71岁,平均41.5岁,其中优势手38例,非优势手13例,双侧9例,病程1.5月-11年,平均4.5年。并发于糖尿病7例,类风湿性关节炎2例,妊娠1例,多发性神经病3例。临床表现:单手麻痛51例,双手麻痛9例,夜间麻醒史57例,大鱼际肌萎缩39例,拇对掌功能受限28例,精细动作受限或无力3例,Tinel征阳性41例。 相似文献
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血管内支架 (EMS)置入术是近年来国内外用于治疗血管狭窄或闭塞的介入放射学新技术 ,球囊导管成形术 (PTA)和血管内支架置入术治疗下腔静脉阻塞综合征 (InferiorVenaCavaSyndrome,IVCS) ,国内已有不少病例报道 ,并取得了较好的临床效果 ,但有关IVCS病因及肿瘤致下腔静脉阻塞的腔外肿瘤CT介入治疗的报道较少。我院于 2 0 0 0年 1月—2 0 0 1年 12月 ,共收集 7例IVCS病例进行总结 ,现将有关IVCS的病因及诊断治疗问题进行研究讨论 ,并探讨肿瘤致下IVCS病例行腔外肿瘤CT介入治疗的疗效。… 相似文献
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目的:探讨脑干听觉诱发电位技术对后颅凹肿瘤术中监护的临床意义。方法:对16例后颅凹肿瘤患者进行术前检查,术中监护,并对BAEP各波波形、潜伏期进行分析。结果:Ⅰ、Ⅲ、Ⅴ波潜伏期延长10例伴Ⅰ—Ⅲ、Ⅲ—Ⅴ或Ⅰ—Ⅴ波波间期延长;波形分化不良或波幅较低6例;手术操作牵拉可引起BAEP不同程度变化。结论:后颅凹占位病变术中的BAEP监护,对保护听觉和脑干功能及术后功能的评估有重要意义。 相似文献
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胶质瘤起源于神经间质细胞 ,包括星形细胞瘤、少枝胶质细胞瘤、室管膜瘤、多形胶质母细胞瘤 ,以星形细胞瘤最为常见。胶质细胞瘤多表现为混合密度 ,其中包括实质性软组织成份、囊性成份、钙化成份。笔者回顾性分析经病理证实的仅表现为单一钙化和单一囊性成份的胶质细胞瘤 ,旨在进一步提高胶质瘤的影像诊断。1 资料与方法本文搜集 1999~ 2 0 0 1年间经外院手术并由江西医学院专家门诊病理科证实的胶质细胞瘤 5例 ,男 3例 ,女 2例。年龄 17~ 72岁。主要临床表现为头痛、四肢功能异常 ,其中2例表现为癫痫发作。 5例均作常规CT平扫 ,3例作… 相似文献