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Many studies have reported the relationship between CXCL12 G801 A polymorphism and cancer risk, with conflicting results. In this study, we tried to clarify the possibility that this polymorphism may increase cancer risk by conducting an updated meta-analysis. Pub Med and EMbase were searched for case-control studies regarding the association of the gene polymorphism and cancer risk. Data were extracted and odds ratios(ORs) with 95% confidence intervals(95% CIs) were used to assess the strength of the association. Heterogeneity among articles and publication bias was also assessed. Significantly increased risk for cancer was found(A vs. G: OR=1.26, 95% CI=1.13–1.40, P<0.01; AA+AG vs. GG: OR=1.33, 95% CI=1.16–1.52, P<0.01). In subgroup analysis, statistically elevated cancer risk was found in both Asian and Caucasian populations(for Asian, AA+AG vs. GG: OR=1.74, 95% CI=1.22–2.47, P<0.01; for Caucasian, AA+AG vs. GG: OR=1.24, 95% CI=1.09–1.42, P<0.01). Our result indicated that CXCL12 G801 A polymorphism is a risk factor for cancer. To validate the finding, further large-size case-control studies are warranted. 相似文献
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<正>慢性阻塞性肺疾病(chronic obstructive pulmoriary disease,COPD)是一种异质性肺部疾病,其特征是由异常的支气管病变(支气管炎、细支气管炎)和/或肺泡(肺气肿)病变引起的慢性呼吸系统症状(呼吸困难、咳嗽、咳痰和/或急性加重),导致持续的、通常是进行性的气流受限[1]。COPD现在是全世界三大死因之一,其中90%的死亡发生在低收入和中等收入国家[2],是一项重大的公共卫生挑战。即使接受最佳的药物治疗(抗胆碱能药物、β2受体激动剂、长效支气管扩张剂、吸入性类固醇和黏液溶解剂等),长期氧疗缓解症状, 相似文献
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目的 观察重型及危重型新型冠状病毒肺炎患者的临床特征及影像学表现,并分析重型及危重型患者死亡相关的风险因素。方法 收集2022年12月20日至2023年1月21日入住宁波市医疗中心李惠利医院(兴宁院区)的180例重型及危重型新型冠状病毒肺炎患者的一般资料、临床特征、实验室结果、影像学表现及死亡等信息,采用SPSS 28.0统计软件进行数据分析。结果 180例新型冠状病毒肺炎患者中,重型134例,危重型46例;男114例,女66例;疫苗接种106例;年龄29~102岁,平均(71.3±12.1)岁;合并基础疾病:高血压81例,糖尿病43例,恶性肿瘤35例,脑血管意外后遗症20例,慢性阻塞性肺疾病12例,间质性肺病8例,冠心病14例,心律失常15例,慢性肾病11例,慢性肝病8例,结缔组织病9例。180例中死亡或自动出院29例(死亡2例,自动出院27例)。重型及危重型患者血中性粒细胞计数/淋巴细胞计数(N/L)比值、C反应蛋白(CRP)、白细胞介素6(IL-6)、D-二聚体、血肌钙蛋白-I水平均明显增高。两组性别、D-二聚体及肌钙蛋白-I水平差异均无统计学意义(均P>0.05),两组年... 相似文献
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