心血管疾病临床抗栓治疗的新进展

近几年,随着抗栓技术的不断发展,越来越多的新型抗栓药物得到临床应用,本文就心血管疾病临床抗栓治疗的新进展进行阐述,为临床治疗提供相关参考。     

缬沙坦联合氨氯地平对高血压患者心功能改善效果分析

目的:探讨缬沙坦联合氨氯地平对高血压患者心功能改善的效果。方法:选择原发性高血压患者168例,分为观察组与对照组,每组84例,对照组单用氨氯地平治疗,观察组采用缬沙坦联合氨氯地平进行治疗。对比两组血压、心功能等指标。结果:两组治疗前后比较,血压均下降明显,心功能均有改善;治疗后组间对比,除血压外,心功能各项指标改善更明显,差异有统计学意义(P<0.05)。结论:缬沙坦联合氨氯地平可较好控制高血压患者血压,且改善心功能的效果显著,值得推广。     

老年慢性心衰患者NT-proBNP及cTnI检测的价值

选择86例确诊为慢性心衰竭(CHF)的老年患者,据NYHA的心功能分级,分为Ⅱ到Ⅳ级。对照组为非老年心脏病患者30例,两组均在入院48h内同时检测血浆NT-proBNP及cTnI浓度。结果 CHF组的血浆NT-proBNP及cTnI均明显高于对照组(P<0.05)。且血浆NT-proBNP浓度与NYHA心功能分级呈正相关。CHF三组间血浆NT-proBNP浓度差异有统计学意义(P<0.05)。但血浆cTnI浓度差异无统计学意义(P>0.05),老年CHF患者随着NYHA分级的增加血浆NT-proBNP及cTnI浓度均渐进增高。两者联合检测对于判断老年CHF患者的心功能有良好的临床应用价值。     

脂肪间充质干细胞移植治疗慢性阻塞性肺疾病

BACKGROUND:Chronic obstructive pulmonary disease is progressive respiratory disease characterized by airflow limitation. OBJECTIVE:To investigate the therapeutic effect of adipose-derived mesenchymal stem cell transplantation in rats with chronic obstructive pulmonary disease. METHODS:Sixty healthy male Sprague-Dawley rats were randomly divided into control, model and treatment groups (n=20 per group). Rat models of chronic obstructive pulmonary disease were made in the model and treatment group, while no treatment was done in the control group. After modeling, rats in the treatment group were given tail vein injection of CM-Dil-labeled adipose-derived mesenchymal stem cells, and rats in the model and control groups given the same amount of normal saline. Rat pulmonary ventilation function, inflammatory factor level and pathological changes of the lung were detected at 14 days after cell transplantation. RESULTS AND CONCLUSION:After modeling, reduced lung function was found in rats with chronic obstructive pulmonary disease, but the cell transplantation significantly improved this reduction (P < 0.05). Compared with the model group, significantly reduced indexes were visible in the treatment group (P < 0.05), including the total number of white blood cells, the number of macrophages and neutrophils, levels of interleukin-8, tumor necrosis factor α and C-reactive protein in the bronchoalveolar lavage fluid as well as serum level of malondialdehyde, while serum superoxide dismutase activity was increased significantly in the treatment group (P < 0.05). In the treatment group, emphysema-like changes were mitigated and CM-Dil-labeled adipose-derived mesenchymal stem cells were capable of homing to the lung tissue of rats with chronic obstructive pulmonary disease and survived. All these findings show that adipose-derived mesenchymal stem cell transplantation can improve lung function of rats with chronic obstructive pulmonary disease, and reduce inflammatory response, which has for certain some therapeutic effects.     

急诊经皮冠状动脉介入治疗急性心肌梗死（附78例报告）

目的观察急诊经皮冠状动脉介入治疗（PCI）治疗急性心肌梗死（AMI）的疗效。方法分析2012年1月~2013年9月对78例AMI患者进行急诊PCI临床资料。结果74例急诊PCI成功，手术成功率94．9％，失败4例，其中死亡1例，死亡率为1．28％，死亡原因为心源性休克。结论急诊PCI治疗AMI成功率高，效果显著，并发症少，值得推广。     

急诊经皮冠状动脉介入治疗急性心肌梗死(附78例报告)

目的观察急诊经皮冠状动脉介入治疗(PCI)治疗急性心肌梗死(AMI)的疗效。方法分析2012年1月~2013年9月对78例AMI患者进行急诊PCI临床资料。结果 74例急诊PCI成功,手术成功率94.9%,失败4例,其中死亡1例,死亡率为1.28%,死亡原因为心源性休克。结论急诊PCI治疗AMI成功率高,效果显著,并发症少,值得推广。     

舒血宁注射液治疗冠心病心绞痛的疗效观察

目的观察舒血宁注射液治疗冠心病心绞痛的临床疗效。方法选取2011年3月—2013年3月在我院就诊的冠心病心绞痛患者80例,将其随机分为观察组和对照组,各40例。对照组进行硝酸甘油舌下含服等一般治疗,观察组采用舒血宁注射液治疗。比较两组心电图(ECG)改善疗效和临床疗效。结果观察组ECG总有效率为95.0%,高于对照组的80.0%,差异有统计学意义(F=4.114,P=0.036)。观察组临床总有效率为90.0%,高于对照组的72.5%,差异有统计学意义(F=4.021,P=0.032)。结论舒血宁注射液治疗冠心病心绞痛疗效较好,症状缓解率高,心电图改善明显,安全有效,值得在临床推广。