营养支持联合美他多辛治疗酒精性肝病患者肝功能和外周血细胞参数的变化

目的 探讨营养支持联合美他多辛治疗酒精性肝病患者对肝功能、红细胞和血小板参数的影响。方法 2015年5月~2017年10月我院诊治的酒精性肝病患者90例,被分为两组,每组45例,分别给予美他多辛片或美他多辛联合营养支持治疗4周,后者为给予35~40 kcat·kg^-1·d^-1的热量。结果 治疗前,两组肝功能指标差异无统计学意义（P>0.05）,治疗结束时,两组血清ALT、GGT和TBIL水平明显降低,ALB明显升高;治疗前,两组凝血功能指标差异无统计学意义（P>0.05）,治疗后两组PT、APTT和TT均明显缩短,FIB显著升高;治疗前,两组红细胞参数和血红蛋白水平差异无统计学意义（P>0.05）,治疗后两组RBC、HGB和HCT均显著上升,RDW和MCV显著下降;治疗前,两组血小板计数（PLT）、血小板平均体积（MPV）和血小板分布宽度（PDW）相比无统计学差异（P>0.05）,治疗后PLT显著上升,MPV和PDW明显降低（P<0.05）,联合组以上变化均显著优于对照组（P<0.05）。结论 营养支持联合美他多辛治疗酒精性肝病患者能够显著改善肝功能、凝血功能、红细胞和血小板参数,提示营养支持治疗可能更重要,需要高度重视。     

乙型肝炎病毒父婴垂直传播

通过在新生儿和青少年中普遍接种乙型肝炎疫苗，我国乙型肝炎病毒(Hepatology B Viros，HBV)的水甲传播有逐渐被控制的趋势，青少年中HBV携带率已由过去的10％—11％下降到5％—6％。但垂直传播特别是宫内感染(即出生前感染，包括母婴或父婴垂直传播)途径尚无可靠的、广泛认同的阻断方法，通过携带HBV的生殖细胞传播给子代的研究还停留在起步阶段。在母婴垂直传播途径和预防方法的研究上取得一定进展的基础上，父婴HBV垂直传播问题逐渐被人们所重视。目前已证实男性HBV携带者精予中可以携带HBV，并可能通过生殖过程传染给子代。     

经肝动脉途径兔自体骨髓干细胞移植治疗肝硬化

BACKGROUND:How to make more transplanted bone marrow stem cells stay and differentiate in the liver is an important issue, which is also crucial for treatment of liver cirrhosis via the hepatic artery. OBJECTIVE:To investigate the therapeutic effect of autologous bone marrow stem cell transplantation via the hepatic artery on liver cirrhosis. METHODS:Thirty New Zealand white rabbits were equivalently randomized into normal control, stem cell transplantation and model groups. Animal models of liver cirrhosis were made in the latter two groups. Then, model rabbits in the stem cell transplantation group were subjected to autologous bone marrow stem cell transplantation via the hepatic artery. Liver function of rabbits was detected in 1, 2, 4, 8, 10 weeks after cell transplantation, and pathological detection of the liver was performed in the 10th week. RESULTS AND CONCLUSION:At 10 weeks after cell transplantation, the liver function of the rabbits was improved significantly compared with the model group, including reduced activities of serum alanine aminotransferase, total bilirubin and aspartate aminotransferase, shortened activated partial thromboplastin time, and increased albumin level (P < 0.05). Pathological examination of the liver showed that the liver cells in the stem cell transplantation group were intact with no obvious edema and still had the structure of the pseudolobule, and compared with the model group, the degree of liver fibrosis was significantly reduced in the stem cell transplantation group. Our experimental results show that the transplantation of autologous bone marrow stem cells via the hepatic artery has a certain therapeutic effect on liver cirrhosis by increasing the body albumin content in a short time and improving the liver function.     

乙型肝炎病毒父婴垂直传播

通过在新生儿和青少年中普遍接种乙型肝炎疫苗，我国乙型肝炎病毒（Hepatitis B Virus，HBV）的水平传播有逐渐被控制的趋势，青少年中HBV携带率已由过去的10％～11％下降到5％～6％。但垂直传播特别是宫内感染（即出生前感染，包括母婴或父婴垂直传播）途径尚无可靠的、广泛认同的阻断方法．对通过携带HBV的生殖细胞传播给子代的研究还停留在起步阶段。在母婴垂直传播途径和预防方法的研究取得一定进展的基础上．父婴HBV垂直传播问题逐渐被人们所重视。目前已证实男性HBV携带者精子中可以携带HBV．并可以通过生殖过程传染给子代。     

饮食护理联合预见性护理在上消化道出血滞留抢救室患者中应用的临床效果及对血清炎症因子的影响

目的 探讨饮食护理联合预见性护理在上消化道出血患者临床护理中的效果.方法 选取2017年1—10月在该院消化内科住院的上消化道出血患者120例作为研究对象,按照随机数字法则,分为两组,每组60例,对照组在基础护理基础上予以饮食护理模式,联合组在对照组护理基础上辅助预见性护理模式,随访6个月,对比两组患者出血次数、止血时...