2型糖尿病患者胃肠道症状发生情况及影响因素分析

目的探讨2型糖尿病患者胃肠道症状发生情况及其影响因素。方法采用一般资料调查表、胃肠道症状分级评分量表(GSRS)、医院焦虑抑郁量表(HADS)对115例2型糖尿病患者进行横断面调查。结果 2型糖尿病患者胃肠道症状总体发生率为67.0%,以消化不良和便秘较为常见;性别、病程、是否存在焦虑/抑郁症状是2型糖尿病患者胃肠道症状的影响因素。结论 2型糖尿病患者胃肠道症状较常见,程度较轻。女性、病程长、有焦虑/抑郁症状的患者胃肠道症状更严重,医护人员应在糖尿病早期开始关注患者的胃肠道症状及心理健康状况。     

糖尿病周围神经病变与肌少症的关联性

目的 探讨2型糖尿病患者糖尿病周围神经病变(DPN)与肌少症的关联性.方法 选取2型糖尿病患者166例,根据骨骼肌质量指数、握力及步速分为肌少症组(n=62)与非肌少症组(n=104);有DPN的症状或体征、同时存在神经传导速度减慢的患者诊断为DPN.应用单因素分析及多因素Logistic回归分析进行统计学处理,比较两...     

血清瘦素水平与2型糖尿病合并脑梗死的关系研究

目的　研究血清瘦素水平与 2型糖尿病 (T2DM)合并脑梗死 (CI)的关系。方法　T2DM患者 1 2 8例 (男 65例 ,女 63例 ) ,其中 63例合并CI,应用酶联免疫法测定其血清瘦素水平。结果　 (1 )T2DM肥胖者血清瘦素水平高于非肥胖者 (P <0 0 0 1 ) ;(2 )血清瘦素水平在不同性别间差异显著 ,女性高于男性 (P <0 0 0 1 ) ;(3)DM合并CI者血清Leptin水平高于无CI者 (P <0 0 5) ;(4)相关分析发现 ,血清瘦素浓度无论男女均与体重指数 (BMI)、腰围 (Waistcircumference ,WC)、腰臀比 (WHR)、体脂百分比 (BF % )、甘油三酯 (TG)、空腹胰岛素 (FINS)等呈显著相关。用多元逐步回归分析发现 ,BF %、性别、FINS、腰围为影响瘦素最为显著的因素。结论　T2DM合并CI者血清瘦素水平升高 ,血清高瘦素水平与高胰岛素血症的相关性提示 ,瘦素可能在T2DM脑梗死的发病中起一定作用     

老年人血清瘦素浓度与糖尿病肾病的相关性研究

目的研究老年人血清瘦素(Leptin)浓度与糖尿病肾病(DN)的相关性。方法应用酶联免疫法测定62例DN患者血清瘦素浓度。结果①肥胖者血清瘦素水平高于非肥胖者(P<0.001);②血清瘦素水平在不同性别间差异显著,女性高于男性(P<0.001);③DN(+)组肥胖者血清瘦素水平为(14.85±5.45)ng/m l,非肥胖者为(7.13±2.77)ng/m l,DN(-)组肥胖者血清瘦素水平为(11.01±4.04)ng/m l,非肥胖者为(5.12±2.86)ng/m l。DN(+)组与DN(-)组比较,瘦素浓度差别具有显著性(P<0.01);④采用Logistic逐步回归分析发现血清瘦素浓度、尿白蛋白排泄率、高血压、高血糖、脂代谢紊乱等为DN的危险因素。结论血清瘦素浓度升高增加了老年人DN发生的危险。     

Effect of Yiqi Huoxue（益气活血） Herbs on Vascular Endothelial Cells and Platelets in Patients with Chronic Cor Pulmonale

Objective: To observe the clinical effect of Yiqi Huoxue (益气活血, YQHX) herbs in treating the patients with chronic cor pulmonale and to explore its mechanism by determining the relationship of oxidation/antioxidation system and how such herbs change on the function of endothelial cells and platelets. Methods: Fifty-eight patients were divided into two groups: conventional therapy group (control group, 28 paventional management. The treated group were treated with YQHX 150 ml, twice a day, plus the conventional treatment, and the clinical efficacy was recorded. The lipid peroxidation (LPO), superoxide dismutase (SOD), α-granule membrane protein (GMP140), partial pressure of arterial oxygen (PaO2), partial pressure of carbon dioxide in artery (PaCO2) and circulating endothelial cells (CEC) were measured respectively before and after treatment, and the relationship between various parameters were analyzed. The results were compared with those of 10 healthy subjects got at the same period. Results: (1) The effective rate and PaO2 of the treated group was higher than that of the control group and there were no difference in PaCO2 between the two groups. (2) The levels of LPO, GMP140, CEC in all the patients before therapy were significantly higher than those of the healthy group, and there were marked decrease in the levels of those after treatment (all P＜0. 01). On the contrary, the levels of SOD in all the patients before therapy were markedly lower than those in the healthy subjects and increased after treatment, P＜0.01. (3) The increase of SOD in the treated group was significantly more obvious than that of the control group. In the treated group, the decrease of LPO, GMP140, CEC were markedly more obvious than those in the control group (all P＜0.01).(4) The number of CEC, as well as GMP140, was negatively correlated to PaO2 (P＜0.01) and SOD (P＜0.01), which was positively correlated to LPO (P＜0.01). There was a positive correlation between CEC and GMP140 (P＜0.05). Conclusion: YQHX herbs in treating chronic cor pulmonale proved to be effective by balancing the oxidation and antioxidation, protecting the pulmonary endothelial cells and activated platelets and helpful in treating respiratory failure.     

环磷腺苷-葡甲胺治疗肺心病心肺功能不全的临床研究

目的 :观察环磷腺苷 -葡甲胺 (葡甲胺 - c AMP)对肺心病失代偿期心肺功能不全的疗效。方法 :使用环磷腺苷 -葡甲胺合并常规疗法治疗肺心病心肺功能不全患者 5 12例 (治疗组 ) ,观察患者治疗前后肺功能、心电图、动脉血气变化 ,同期对比观察安慰剂合并常规治疗 2 73例 (对照组 )。结果 :治疗组总有效率和显效率分别为 92 .2 %和 73.8% ,明显高于对照组 73.6 %和 4 9.5 % ( P <0 .0 5 )。两组治疗后 VC、FEV1 和 PEF、Pa O2 均明显增加 ,治疗组更显著 ( P <0 .0 5 )。治疗组心电图有效率为 6 3.7% ,明显高于对照组 4 1.2 % ( P <0 .0 5 )。两组均未见明显的不良反应。结论 :环磷腺苷 -葡甲胺可改善肺心病患者的心肺功能。     

血清抵抗素水平与2型糖尿病神经病变的相关性

目的探讨抵抗素在2型糖尿病神经病变发生、发展中的作用。方法采用ELISA法检测58例2型糖尿病伴神经病变患者（观察组）血清抵抗素水平,并与40例2型糖尿病不伴神经病变患者（对照组）比较,对抵抗素水平与其他相关检测指标进行相关性分析。结果神经病变组血清抵抗素水平明显高于对照组,P〈0.05;血清抵抗素水平与FPG、HbA1c、TG、FINS、SBP、DBP、Homa-IR呈正相关,P均〈0.05。结论血清抵抗素与2型糖尿病神经病变存在相关性,其可能在2型糖尿病及其微血管病变的发生中起作用。     

辽东山区水生毛细线虫危害林蛙卵的观察及防制对策

中国林蛙是珍贵的野生动物,俗称哈什蚂。近年来由于森林资源大量砍伐,林蛙生态环境不断遭到破坏,其生存条件恶化。另外,个别地域发生病虫害,从而导致野生林蛙资源日趋减少。为此,我们根据毛细线虫危害蛙卵发生规律及危害特征和时间,提出综合防制对策。1寄主与危害发生规律水生毛细线虫4月上旬发生,中下旬较重,主要寄生在蛙卵中吸食营养,破坏黑色卵核,极大影响胚胎变形转化。4月上旬至中下旬是林蛙的产卵期,其适宜温度8～11℃,林蛙产卵后其胶膜吸水膨胀,漂在水面上,这时期是毛细线虫危害蛙卵的主要受害期,当毛细线虫借助稳水的浮力流动到蛙卵…     

院外延续宣教对糖尿病足中高危人群自护行为的影响研究

目的：探讨远程护理干预对2型糖尿病足中高危患者足部自护行为及血糖的影响。方法在2011年1～5月住院的糖尿病患者中,筛选出糖尿病足中高危患者60例为研究对象,随机分为对照组及干预组。对照组采取常规出院随访,干预组采取远程延续信函结合电话强化健康指导。比较两组患者在院时和出院2年后的足部自护行为、血糖值及糖尿病足危险因素评分。结果干预组患者干预前后的足部自护行为差异有显著意义（P＜0．05）,与对照组比较差异有显著意义（P＜0．05）。在血糖值、糖尿病足危险因素评分等方面比较两组差异无显著意义。结论针对性的远程宣教,可以提高糖尿病足中高危患者的足部自护行为,但宣教模式还可进一步完善。     

血清瘦素水平与糖尿病合并脑梗死关系的临床研究

目的探讨血清瘦素水平与2型糖尿病(DM)合并脑梗死的关系。方法应用酶联免疫法测定128例(非肥胖者62例,肥胖者66例)DM患者(其中合并脑梗死者63例)的血清瘦素水平,并对合并脑梗死者的瘦素水平、血脂、血糖、血压、体质量指数等进行相关分析。结果(1)DM肥胖者血清瘦素水平高于非肥胖者(P<0·001);(2)女性血清瘦素水平[(13·00±5·20)ng/ml]显著高于男性[(6·84±2·57)ng/ml](P<0·001);(3)DM合并脑梗死者血清瘦素水平高于无脑梗死者(P<0·05);(4)采用Logistic逐步回归分析发现血清瘦素水平、高血脂、高血糖、高血压、体质量指数等为脑梗死发生的危险因素。结论2型DM合并脑梗死血清瘦素水平升高,瘦素可能在2型DM脑梗死的发病中起一定作用。