An experimental study of intravascular stent in abdominal aorta of atherosclerotic miniature pigs.

To study the effects of nitinol alloy stent in the treatment of atherosclerotic arterial stenosis, eight miniature pigs were subject to abdominal aortic balloon denudation and high-fatty food. Then 8 nitinol alloy stents were implanted into each abdominal aortas of pigs. The pigs were equally divided into two groups. One group was given captopril (3 mg / kg / d). All animals were sacrified) for pathological examination 6 to 10 months after stent implantation. The degree of arterial intima proliferation in the areas of stent implantation not significantly different from that of areas of balloon denudation alone; the atherosclerotic lesions were found at the arterial surface of stent implantation sites. The intima layer was rich in smooth muscle cells, with atherosclerotic plaque formed around the stent wire. On the other hand, significant decrease in arterial intima proliferation was found in group Ⅱ with no atherosclerotic plaque. The arterial stenosis resulting from atherosclerotic lesion could not be     

农村冠心病易患因素的多元分析

报告1100名35岁以上农民冠心病患病率及易患因素的调查结果。全组中检出冠心病15例,其中陈旧心肌梗塞3例、心绞痛7例、心律失常及不典型心绞痛伴有心电图缺血型改变者5例,冠心病现患率为1.36%。另有单纯ST-T 缺血型改变84例,各种严重心律失常36例,未计入冠心病现患率之内.经单变量线性相关及多变量Logistic 函数分析结果,选出有意义的冠心病易患因素有甘油三酯、年龄及收缩期血压增高,以及血浆高密度脂蛋白胆固醇的降低。     

Experimental study on the occlusion of arterial blood flow by the implantation of nitinol alloy stents.

To evaluate the occlusion of arteries, 6 conic intravaseular endoprosthetic stents of titanium-nickel alloy were implanted transluminally to the right external iliac arteries in 2 normal dogs and 4 normal pigs. The stent was characterized by ductility below 313 K (40℃) and restoration memory-shape between 313-319 K. The diameter of the large end of conic stent was 4.0 mm (dog) and 4.5 mm(pig). The topographic anatomy showed that the external iliac artery was near complete occlusion, with a very small residual lumen (about 1 mm in diameter) in dogs at 6 months, with complete occlusion in pigs at 8 months. The histopathological examination indicated that the arterial intima of the upper branch from the stented site was smooth, and that neither inflammatory cell infiltration nor foreign giant cell reaction was found. The newly formed granulation tissue inside the stent came from emboli organization. These results suggest that the shape-memory alloy stent has good biocompatibility and the conic intravascnla     

糖尿病病人心收缩时间间期测定的临床意义

糖尿病性心脏病是糖尿病重要并发症之一,可直接引起心力衰竭或猝死,也是影响糖尿病心肌梗塞预后的重要因素。本文通过非创伤性方法测定糖尿病病人左心功能,探讨其临床意义,目的是为了早期诊断糖尿病病人心肌损害,以及时防治之。     

肌球蛋白轻链磷酸化与心肌损伤的实验研究

应用水平平板等电聚焦(电压2000V,时间2.5h、pH 4～6)、银染和凝胶光密度扫描相结合的一种新方法,研究去甲肾上腺素性心肌损伤兔心肌肌球蛋白轻链磷酸化(P-MLC/MLC×100%)的改变及α、β受体阻滞剂对该改变的影响。结果表明,去甲肾上腺素(NE,2mg/kg)显著降低心肌的P-MLC/MLC(P-MLC/MLC为35.40±5.37%;对照组为61.07±6.97%,P<0.01),酚妥拉明(10mg/只)可保护心肌P-MLC 66.43±8.43%,而普萘洛尔则无此作用(P-MLC/MLC为36.54±4.05%)。     

三磷酸腺苷静注诊断10例隐性预激综合征

选择窦性心律时心电图无心室预激波(PEC)的44例阵发性室上速和6例仅有短PR间期者施行三磷酸腺苷(ATP)分级递增快速静注(ATP_Ⅳ)和诊断性电生理研究(DEPS)。结果:ATP_Ⅳ和DEPS分别揭示出隐性预激综合征(PE_L)10/50例和9/50例;ATP_Ⅳ揭示的10例PE_L中有6例在显示PEC前或中出现非预激搏动的房室结传导延缓或阻滞;ATP_Ⅳ未生严重并发症。提示(1)ATP_Ⅳ是诊断PE_L的一种简便、敏感和较安全的方法;(2)ATP_Ⅳ时PEC的揭示主要与ATP对房室结前向传导的负性变导性作用有关。     

糖尿病人中左心功能的变化

41例糖尿病人和55例正常人测定了收缩时间间期和舒张时间间期。糖尿病人中[PEP]I,ICT,P/L值有意义的增加,而[Q-S_2]I,[LVET]I,A/E-O%,IRT,SFW/RFW与正常人无明显差异。P/L值异常发生率最高,达24.4%。故收缩时间间期,尤其P/L值可作为了解糖尿病心脏功能改变的较好临床指标。     

放射配基结合抑制分析监测抗β受体抗体应答

通过正交试验改良放射配基(~(125)I-心得静)结合抑制分析(RBIA),所得的最佳实验条件为孵育温度30℃,缓冲液pH7.4,加血清预孵育40min,加~(125)I-PIN孵育20min;用于监测猪心肌细胞膜免疫BALB/c小鼠的抗β受体抗体应答,其血清中抗体对~(125)I-PIN结合β受体的抑制呈浓度依赖性,且为非竞争性抑制。同时还讨论了RBIA对于测定病人体内循环抗β受体自身抗体的临床应用价值。     

高血压糖尿病大鼠心脏超微结构动态观察

用ＳＤ大鼠造成实验性高血压糖尿病（ＨＤ）后，分别于６、８和１０个月处死，每组８例，用光镜及透射电镜动态观察心脏变化。结果提示：首先出现，心脏小动脉壁增厚、腔变窄，随后出现心肌细胞的变性或坏死，以及替代性纤维化和间质性纤维化。并对扩张型心肌病的病理形态学发生机理作了探讨。     

原发性扩张型心肌病

按照病理生理学分类,心肌病可分为扩张型(充血型)、肥厚型、梗阻型、限制型及不定型五种类型,而以扩张型最多见。扩张型心肌病的特点是心室扩大,泵功能降低,心排出量减少,心室充盈压升高,表现为充血性心力衰竭。病因心肌病可分为原发性和继发性二大