Expression of EGFR and LRIG-1 in Human Trigeminal Neurinoma

The expression of epidermal growth factor receptor （EGFR） and leucine-rich repeats and immunoglobulin-like domain 1 （LRIG-1） in human trigeminal neurinoma was investigated and their effect on the origination and development of trigeminal neurinoma, and the relationship between them was studied. By using immunohistochemistry：with tissue chip, the expression of EGFR and LRIG-1 was detected in 23 cases of trigeminal neurinoma. It was found that in the 23 cases, the expression rate of EGFR was 21.74%, while that of the LRIG-1 was 78. 26 %. There was a negative correlation between them. It was suggested that LRIG-1 might inhibit the malignant differentiation and proliferation of the trigeminal neurinoma possibly by the negative feedback loop of EGFR.     

84例体外循环心脏直视手术对肝功能的影响

目的:探讨体外循环心脏直视手术对肝功能的影响。方法:84例体外循环心脏直视手术患者于术前,术后第1、2、7天检查肝功能指标。结果:手术后肝功能异常者占28.5％(24/84);手术后谷丙转氨酶、谷草转氨酶水平无显著变化,总胆红素、直接胆红素水平显著升高(P<0.05)。结论:体外循环心内直视手术对肝功能有一定的影响,但不影响患者病情的康复。     

脑肿瘤中以EGFR为靶点治疗的进展

表皮生长因子受体(epidermal growth factor receptor,EGFR)对细胞的增殖和分化起重要作用,与绝大多数脑肿瘤的发生和发展密切相关.近年来针对EGFR的靶向性治疗研究日趋多样化,显示出较好的应用前景.     

转化生长因子-β1基因治疗对种植体周骨质疏松的影响

目的探讨转化生长因子- β1（TGF- β1）基因治疗对种植体周围骨质疏松和骨缺损的影响。方法构建pCDNA3.1（+）- TGF- β1真核表达载体，转染大鼠骨髓间充质干细胞（BMSCs），并与聚乳酸- 羟基乙酸（PLGA）体外黏附。制备骨质疏松大鼠股骨植入钛种植体模型，将24只Wister大鼠随机分为实验组、对照组和空白对照组，实验组为在种植体周骨缺损处植入TGF- β1基因修饰BMSCs复合PLGA；对照组为BMSCs复合PLGA。术后第4和8周取标本行免疫组化和组织学分析，观察种植体周骨组织中TGF- β1的表达和组织学变化。结果术后第4周，实验组骨缺损区的TGF- β1表达较对照组和空白对照组明显；第8周实验组骨缺损区被新生骨充填，骨质较对照组和空白对照组明显改善。结论TGF- β1基因修饰BMSCs体内回植后，可在种植体周围骨组织内表达TGF- β1，并可以影响种植体周骨缺损的修复和骨质疏松状况。