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脂多糖致肺血管内巨噬细胞分泌功能的改变 总被引:1,自引:0,他引:1
目的 探讨肺血管内巨噬细胞(PIM)在感染性急性肺损伤(ALI)发病中的作用.方法 采用改良Morton法分离、培养猪PIM;用贴壁法获得黏附的PIM,培养于RPMI 1640培养基,予10 mg/L脂多糖(LPS)刺激.用鼠胸腺细胞增殖法测定白细胞介素-1β(IL-1β)活性,酶联免疫吸附法(ELISA)测定IL-6、IL-8含量.结果 LPS刺激后,PIM释放IL-1β、IL-6和IL-8均增多,峰值分别出现在刺激后的2 h[IL-1β活性(10 400±2 389)次/min]、4 h[IL-6含量(0.80±0.36)μg/L]和6 h[IL-8含量(4.94±1.19)μg/L],与刺激前[IL-1β活性(213±85)次/min,IL-6含量(0.27±0.12)μg/L,IL-8含量(1.84±0.53)μg/L]比较差异均有统计学意义(均P<0.01).结论 LPS刺激后,PIM分泌多种细胞因子,其中IL-1β升高最早,提示其在ALI发病早期起重要作用;而IL-6、IL-8升高较晚,且持续时间较长,可能对ALI的病情进展起重要作用.细胞因子间的相互作用在ALI的发病中似乎更为重要.Abstract: Objective To investigate the role of pulmonary intravascular macrophages(PIMs)in the pathogenesis of acute lung injury(ALI)due to infection. Methods Porcine pulmonary blood vessels were flushed by modified Morton method, and PIMs were isolated and cultured. The adhered PIMs were collected with adhesion method and incubated in RPMI 1640 medium. They were challenged with lipopolysaccharide (LPS, 10 mg/L). The activity of interleukin-1β(IL-1β), and contents of IL-6 and IL-8 in the culture supernatant were measured by method of thymocyte proliferation and enzyme linked immunoadsorbent assay (ELISA). Results The released contents of IL-1β, IL-6 and IL-8 from PIMs were increased significantly compared with those before LPS challenge, and they peaked at 2 hours[IL-1β activity:(10 400±2 389)scintillant count/min], 4 hours[IL-6 content:(0. 80± 0. 36)μg/L], and 6 hours[IL-8 content:(4. 94± 1.19)μg/L]after LPS challenge, and the differences were significant compared with those before LPS challenge[IL-1β activity:(213±85)scintillant count/min, IL-6 content:(0. 27 ± 0. 12)μg/L, IL-8 content:(1.84±0.53)μg/L, all P<0. 01]. Conclusion Among the cytokines released from PIMs after LPS challenge, the increase in IL-1β occurred earlier in comparison with that of IL-6 and IL-8, suggesting that the former might play an important role at the early stage of ALI; on the other hand, though the increase in IL-6 and IL-8 contents occurred later than that of IL-1β but it lasted for a longer duration,suggesting that they might be associated with the advancement of ALI. The results also suggested that interaction of these cytokines played a more important role in the pathogenesis of ALI. 相似文献
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患者女,80岁,因突发腹胀、心前区疼痛伴左上肢体麻木30 min入院.患者平素身体健康,有高血压病、冠心病等病史.体检:体温36℃,脉搏76次/min,呼吸18次/min,血压150/90 mm Hg,痛苦貌,心肺(-),腹壁无膨隆,全腹软,剑下压痛明显,余腹部无压痛及反跳痛.各项检查结果如下:心电图:窦性心律,心电轴+6°,Ⅰ、Ⅱ、Ⅲ、aVF、V3~V6导联ST段轻微下移,V1~V4导联T波倒置.腹部平片:肠管积气.心肌酶五项:谷草转氨酶46 U/L,门诊拟诊胸痛原因待查,不稳定型心绞痛入院.入院后给予吸氧、心电监护,硝酸甘油持续泵入、美托洛尔控制心率、极化液营养心脏等对症治疗. 相似文献
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李胜亮 《国外医学:呼吸系统分册》1996,16(4):197-200
肺血管内巨噬细胞(PIM)是单核吞噬细胞系统的成员,是肺巨噬细胞亚群之一。本着重综述PIM的结构、生物活性及其在急性肺损伤中的作用。 相似文献
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目的探讨急诊超声对输尿管结石的诊断价值。方法对经急诊超声检查的144例输尿管结石伴14例肾周积液的病例行回顾性总结,分析声像图特征,总结诊断方法及体会。结果 144例患者中首次确诊者101例,占70.1%(101/144),二次以上复查确诊者42例,占29.2%(42/144),仅1例未检出,占0.7%(1/144),14例伴肾周积液表现为肾周线条状或月牙形液性暗区。结论急诊超声对输尿管结石具有独特的诊断价值,应用多体位、多切面的检查方法能提高输尿管结石的检出率,能及时发现有无合并肾周积液,动态观察其变化,对临床诊治具有重要指导意义。 相似文献
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脂多糖致肺血管内巨噬细胞释放几种细胞因子的改变 总被引:1,自引:0,他引:1
目的 探讨肺血管内巨噬细胞(PIM)释放的细胞因子在感染性急性肺损伤(ALI)发病中的作用。方法 仿Morton法灌洗肺血管床,贴壁法分离猪PIM,培养于PIM1640培养基,予10μg/ml脂多糖(LPS)刺激,胸腺细胞增殖法测PIM培养上清白细胞介素1β(IL-1β)活性,酶联免疫吸附试验(ELISA)法测肿瘤坏死因子α(TNFα)、白细胞介素6(IL-6)、白细胞介素8(IL-8)含量。结果 相似文献
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患者男,42岁。主因咽喉部及右侧颈部疼痛不适3天来院就诊。临床检查:咽、喉部充血水肿,双侧下颌区肿胀,血常规:血象增高。临床申请腮腺、颌下腺、舌下腺、淋巴结超声检查。超声所见:双侧腮腺及下颌下腺体积增大,回声不均匀性减低,CDFI:示其内血供丰富,双侧颈部可见多个肿大淋巴结结节,舌下腺区可见范围约27mm×12mm的无回声区,内见多发条状回声(图1~4)。 相似文献
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1 病例报告 例1 女性,66岁,因颜面水肿,腰痛,尿少6d于1997年9月2日入院。入院10d前因受凉出现头痛、发热,自服“APC”3~4片/d,3d内共服10片,第4天后出现颜面部水肿,腰痛,伴尿少、乏力、纳差、恶心、呕吐。既往无高血压病史。体检:血压20.0/13.0kPa,眼睑及双下 相似文献