排序方式: 共有11条查询结果,搜索用时 78 毫秒
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通常认为幽门螺旋菌感染不仅与慢性胃炎发病有关,也可能增加患胃癌的危险性。为确定幽门螺旋菌感染与胃癌的联系,作者选择69例组织学诊断为胃腺癌的病人(其中32例贲门癌,37例胃的其他部位癌);对218例非胃腺癌病人(其中80例结肠腺癌,79例肺鳞状细胞癌,41 相似文献
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我们于1978~1980年间在我国十个县,完成了686对病例-对照研究。本次调查发现胃癌与霉粮霉饭、饮食不规律,精神创伤及家族胃癌史等有关。有7个县霉粮霉饭因素相对危险性大于2,RRMH为2.06.精神创伤因素RR大于2.8的有7个县。饮食不规律因素RR ≥ 2的有5个县,RRMH为1.28(P<0.05)。病例组家族胃癌患病率为7.58‰,对照组家族胃癌患病率为4.02‰,前者显著高于后者(P<0.01)。调查发现新鲜蔬菜RRMH为0.88,说明它是保护因素之一。 相似文献
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胃癌预防的研究 总被引:11,自引:0,他引:11
病例对照研究发现酸煎饼、咸鱼、慢性胃炎、家族史及吸烟均是胃癌的危险因素,葱蒜类蔬菜有强保护作用。3400例胃镜检查CAG(慢性萎缩性胃炎)、IM(肠上皮化生)及DYS(不典型增生)的发生率分别为98%、53%及20%。如以最高病变诊断标准计算,则SG(浅表性胃炎)1.7%,CAG44.8%,IM33.0%,DYS20%。各种癌前病变发展至胃癌呈线性进展型,其OR(危险度)分别为:浅表型IM13.8,深度IM34.6,轻度DYS25.8,中或重度DYS103.8。受检人群中幽门螺杆菌抗体阳性者占72%,与胃粘膜病变的程度相关。PG(胃蛋白酶原)Ⅰ∶Ⅱ随病变的进展而逐步降低,SG9.1,CAG7.2,IM5.7,DYS5.4及GC(胃癌)3.8。基于上述研究结果,1995年秋开展了胃癌前病变的随机化前瞻性干预试验 相似文献
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A study of precancerous gastric lesion was conducted in a randomly selected high risk population in Linqu, Shandong Province of China. 849 subjects aged from 30-64 were examined bioptically. There were 8 cases of gastric cancer, the prevalence rate was 0.9%. 169 subjects were diagnosed to be dysplasia, the prevalence rate of dysplasia was increased significantly with age. The regression equation was Y=0.47X-0.25. The prevalence of CAG was found in 36 per cent of the studied subjects and both dysplasia and CAG were more serious in the antrum than the. fundus. The results showed a natural history of precancerous gastric lesions in a high risk population in a high risk area. 相似文献
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游伟程 William J.Blot 昌云生 李吉友 金懋林 谢玉泉 Robert W.Kneller 杨伯琴 韩忠祥 刘伟东 赵雷 张联 杨祖田 Joseph F.Fraumeni Jr 徐光炜 《中国癌症研究》1993,5(2):83-88
A population-based screening for stomach cancer (SC) and its precancerous lesions was conducted in Linqu County, Shandong, China, one of the highest SC rates found in China and the world. An analysis of precancerous stomach lesions revealed that chronic atrophic gastritis (CAG) was a universal common among people aged 35-64 (96-98%). For 52% and 20% of the residents in this age group had Intestinal metaplasia (IM) or dysplssia (DYS). These more advanced lesions were more pronounced in the antrum for both males and females. Age-specific prevalence rates in different anatomic locations sshowed that CAG, developed in the antrum, particularly along the lesser curvature earter than other sites and spread to fundus. IM and DYS accrued under the background of CAG with a leading time in the antrum than the other part of the stomach. Although CAG, IM and DYS prevalence rates were higher in the antrum than In the fundus, the prevalence rates showed a similar smoothly slope, a result of accumulated somatic genetic 相似文献
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昌云生 游伟程 张联 赵雷 马骏岭 刘宪秋 刘伟东 RobertW.Kneller 张劲松 MichealI.Samloff WilliamJ.Blot 《中国癌症研究》1993,5(3):157-164
The relationships between serum pepsinogen (PG) levels and age, sex, ABO blood type, cigarette smoking and diet were studied among over 3, 000 residents selected at random in an area with high risk of stomach cancer in Shandong Province, China. Males had significantly higher median PG Ⅰ and Ⅱ levels than feamles. PG Ⅰ tended to decrease and PG Ⅱ to rise with age. Subjects with blood type A had a higher PG Ⅱ level than subjects with other blood types. Both PG Ⅰ and Ⅱ levels rose with dally consumption of cigarettes. Alcohol consumption was not related to PG levels. The PG Ⅰ/Ⅱ ratio declined with increasing consumption of sour pancakes, a fermented staple food found to contain N-nitroso compounds and to be a risk factor for stomach cancer in this population. 相似文献
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目的:从分子流行病学水平探讨myc等基因在体亚硝酸胺(NAD)致胃癌过程中的作用。方法:进行胃液总NAD含量测定和胃窦部粘膜活检及免疫组化染色。结果:57.1%的胃液样品检出NAD,pan-mycp62过表达率在胃液NAD阳性者和阴性者中差异显著(P=0.0239);pan-rasp21、c-erbB-2P185和突变型P53的表达无此差异。结论:myc基因可能在NAD致人胃癌过程的早期发挥作用。 相似文献