Spatial-temporal Analysis of Tuberculosis at the Community Level in the Baoshan District,Shanghai 2014–2019

<正>Mycobacterium tuberculosis is the primary bacteria that leads to human tuberculosis(TB),which usually affects the pulmonary organs. TB is one of the top 10 causes of death worldwide;however, China is one of eight countries that together account for two-thirds of the total number of cases globally.     

磷酸化信号传导与转录激活因子3在前列腺癌早期诊断中的应用

目的 探讨前列腺穿刺标本中磷酸化信号传导与转录激活因子3(P-STAT3)表达在前列腺癌(PCa)早期诊断中的应用价值.方法采用免疫组织化学方法检测接受重复穿刺的PCa患者初次穿刺未检出癌的标本(29例)、重复穿刺确诊PCa时的癌灶标本(29例)、重复穿刺确诊PCa时的非癌灶标本(29例)以及良性前列腺增生(BPH)患者初次穿刺标本(29例)中P-STAT3的表达.统计学分析其与临床诊断的相关性及对PCa发生的预测作用.结果 P-STAT3在PCa患者癌灶标本、非癌灶标本及初次穿刺标本中阳性表达率分别为93.1%(27/29)、82.8%(24/29)和86.2%(25/29),在BPH标本中阳性表达率为10.3%(3/29),前三者的阳性率明显高于后者(X2=60.123,P=0.000);如以初次穿刺标本中P-STAT3表达阳性作为PCa的诊断标准,该方法的敏感性为86.2%,特异性为89.7%.结论 检测穿刺标本P-STAT3表达可以作为前列腺穿刺活检的辅助诊断方法,用于PCa的早期诊断,预测PCa的发生.     

脾动脉起始部真性动脉瘤的手术治疗(附7例报告)

目的：探讨脾动脉起始部真性动脉瘤的手术治疗方法，总结临床治疗经验。方法：回顾性总结1996年1月至2006年8月收治的7例病人，经彩色超声、CT和血管造影检查证实脾动脉起始部真性动脉瘤；均在全身麻醉下行动脉瘤切除，5例行脾动脉血管重建，2例同时行脾脏切除。结果：手术后10—14d治愈出院。随访1—9年，1例人工血管转流术后2年死于急性心肌梗塞，余6例均健康生活。无复发。结论：脾动脉起始部真性动脉瘤切除、脾动脉重建是—种较好的治疗方案。     

ComparisonoftripletherapywithlansoprazoleorfamotidineforHelicobacterpyloriassociatedduodenalulcer

ＣｏｍｐａｒｉｓｏｎｏｆｔｒｉｐｌｅｔｈｅｒａｐｙｗｉｔｈｌａｎｓｏｐｒａｚｏｌｅｏｒｆａｍｏｔｉｄｉｎｅｆｏｒＨｅｌｉｃｏｂａｃｔｅｒｐｙｌｏｒｉａｓｓｏｃｉａｔｅｄｄｕｏｄｅｎａｌｕｌｃｅｒＷＡＮＧＸｉａｏＺｈｏｎｇ，ＬＩＢｉｎａｎｄＬＩＮＧ...     

多潘立酮在增强结肠运动中的作用

Objective To observe the prokinetic effect of domperidone on colon and compare with that of mosapride and cisapride.Methods ① In viva experiment:forty rats were divided into control,domperidone,mosapride,and cisapride groups with 10 in each group.Stran gauges were planted both in proximal and distal colons and colonic motor activities were recoded in conscious rats.② In vitro experiment:the prokinetics effects of dopamine or dopamine combined with domperidone on the contraction of isolated rat colon strips were recorded by tone-transducers in the thermostatic muscle bath.Results In viva experiments:① in the interdigestive period of resting,activities of rhythimic phasic contraction were recoded in colon at conscious rats,and ② it had been showed that dornperidone significantly enhanced the contraction of colon in dose-dependent manner.Compared with control group,the mean contraction amplitude of proximal colon and distal colon increased by 84.61% ± 7.26% and 76.37 % ± 8.47% in domeridone group,respectively,which was higher than those in mosapride group (50.32%±8.16% and 45.13%±7.16%,respectively),but as same as those in cisapride group (92.55% ± 8.37% and 81.27% ± 9.95%,respectively).In vitro experiments:① perfusion of dopamin (40 mg/ml) could significantly decrease the contraction of isolated colon strip by 91.56% ± 10.24% in comparison with Krebs-Ringer solution,and ① domperidone could block the relaxant effect of dopamin on the isolated colon strip.Conclusions Domperidone can significantly enhance the colonic motor activities via antidopaminergic action.The effects of domperidone are similar as eisapride and greater than mosapride.     

Influence of Chemical Oxygen Demand Concentrations on Anaerobic Ammonium Oxidation by Granular Sludge From EGSB Reactor

INTRODUCTION The phenomenon of anaerobic ammonium oxidation was originally discovered in a denitrifying fluidized-bed reactor treating effluent from a methanogenic reactor in the 1990s[1]. Anaerobic ammonium oxidation (ANAMMOX) process is a strictly anaerobic denitrification process, in which ANAMMOX autotrophic bacteria directly oxidize ammonium to dinitrogen gas using nitrite as electron acceptor. In recent years, the anammox process has received great attention and lots of researc…     

Establishment and application of experimental model of human fetal hepatocytes: protective effects of silybin and polyporus umbelalus polysaccharides on human fetal hepatocytes

Ｅｓｔａｂｌｉｓｈｍｅｎｔａｎｄａｐｐｌｉｃａｔｉｏｎｏｆｅｘｐｅｒｉｍｅｎｔａｌｍｏｄｅｌｏｆｈｕｍａｎｆｅｔａｌｈｅｐａｔｏｃｙｔｅｓ：ｐｒｏｔｅｃｔｉｖｅｅｆｆｅｃｔｓｏｆｓｉｌｙｂｉｎａｎｄｐｏｌｙｐｏｒｕｓｕｍｂｅｌａｌｕｓｐｏｌｙｓａｃ...     

hCG/ATP-induced Leydig cell calcium channel reaction at different extracellular calcium ion concentration

Objective: To study the calcium channel reaction of human Leydig cells induced by hCG/ATP at different extracellular calcium ion concentrations. Methods: The Leydig cell calcium ion concentration was examined with laser confocal microscope, when the cells were stimulated with hCG/ATP at different extracellular calcium contrations. Results: With calcium-containing extracellular fluid, the Leydig cells were sensitive to hCG stimulation and when the extracellular fluid was calcium-free, the Leydig cells did not respond to the stimulation. However, the Leydig cells did respond to ATP stimulation no matter the extracellular fluid contained calcium or not. Conclusion: In human Leydig cells, there are calcium channels sensitive to hCG and ATP. The extracellular calcium ion concentration plays an important role in the regulation of Leydig cell metabolism by hCG/ATP.