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目的探讨胆道支架、十二指肠支架置入治疗胆道合并十二指肠恶性梗阻的临床价值。方法2008年1月~2013年12月,对24例同时存在胆道和十二指肠恶性梗阻的患者完成胆道支架、十二指肠支架置入,其中介入中心10例患者行经皮肝穿刺造影完成胆道金属支架置入(percutaneoustranshepaticinsertionofbiliarystent,PTIBS),14例消化内镜中心患者行逆行胰胆管造影放置胆道金属支架(endoscopicretrogradecholangiopancreatography—guidedbiliarystent,ERCP.BS),其中1例失败后改行经皮肝穿刺胆管外引流术不纳入随访研究。胆管支架置入术后1周完成十二指肠支架置入。观察手术成功率、临床症状缓解率、并发症、支架通畅时间及患者生存期等指标。结果联合支架置入成功率95.8%(23/24),梗阻症状消失率87.0%(20/23);十二指肠支架置入术后1周胃出口梗阻评分(2分6例,3分17例)较术前(O分6例,1分17例)明显改善(Z=-4.796,P=0.000)。胆道支架通畅时间(73.9±5.3)d,生存时间(93.0±4.9)d。十二指肠支架再发梗阻率17.4%(4/23)。均未出现严重并发症。结论胆道、十二指肠支架联合置入治疗恶性胆道、十二指肠梗阻安全有效。 相似文献
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Objective To investigate the inhibitory effect of danshensu on the activation of JNK signaling in rat hepatic stellate cells (HSCs) induced by IL-1 β. Methods The proliferation of primary rat HSCs treated with different concentration of Danshensu was checked by MTT colorimetric assay. The expres-sion and phosphorylation of JNK and P-JNK was detected by western blotting. Synthesis and secretion of collagen Ⅰ were detected by the quantitative immunocytochemical assay and ELISA. Results Danshensu inhibited the proliferation of HSCs in a dose-dependent manner. At the concentration of 0.0625 to 0.25 mmol/L, Danshensu significantly repressed the proliferation of HSC induced by IL-115 (P < 0.05). Synthesis and secretion of Type β collagen was significantly decreased 24 hours after 0.25 mmol/L Danshensu treatment (P < 0.01). The phosphorylation of JNK induced by IL-1 β was significantly inhibited by Danshensu treatment (P < 0.05), however, the expression of JNK was not regulated by Danshensu. Conelutions Danshensu represses the activation and proliferation of HSCs, and inhibits the synthesis and secretion of Type β collagen, possibly via the repression of the JNK signal transduction. 相似文献
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目的:中药可减少丙戊酸钠的用量,减轻其毒副作用,延缓脑梗死后癫痫的病情进展,并可提高脑梗死的治疗效果。方法:采用随机双盲安慰剂对照试验设计方法,选择60例癫痫患者,中医辨证证型均为风痰闭窍,癖阻脑络者,分为西药对照组、西药+中药组,分别服用,疗程104周。观察:①中医证侯疗效;②对患者发作次数的影响;③对患者脑电图的影响;④对患者生活质量的影响;⑤对患者认知功能的影响。⑥安全性观察。结果:①患者发作次数减少,治疗组和对照组总有效率分别为85.9%和63.1%,两组比较有统计学意义(P<0.05)。②中医证候疗效,治疗组和对照组总有效率分别为82.8%(24/29)和71.4%(20/28),两组比较有统计学意义(P<0.05)。③脑电图改变明显好转两组脑电图比较,治疗组总有效率82.7%(24/29),对照组总有效率57.1%(16/28),差异有统计学意义(U=1.87,P<0.05)。④生活质量:治疗组改善生活质量优于对照组(P<0.05)。⑤认知功能评价:中药治疗组改善认知障碍优于西药对照组(P<0.05)。⑥安全性观察:治疗组和对照组无明显不良反应。结论:中药可以提高脑梗死后癫痫的治疗效果,具有明显疗效和良好的安全性。 相似文献
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丹参素对大鼠肝星状细胞氨基末端蛋白激酶信号转导的影响 总被引:1,自引:0,他引:1
目的 探讨丹参素抗肝纤维化作用的机制. 方法分离大鼠原代肝星状细胞(HSC),用0.0312、0.0625、0.1250、0.2500、0.5000、1.0000 mmol/I.不同浓度丹参素作用于HSC,四甲基偶氮唑黼法检测丹参素对HSC生长增殖的抑制作用;应用免疫细胞化学法观察Ⅰ型胶原合成,酶联免疫吸附法观察Ⅰ型胶原分泌.Western blot法观察丹参索对白细胞介素-1 β(IL-1 β)刺激的HSC内氨基末端蛋白激酶(JNK)蛋白及其磷酸化表达的影响.采用随机设计的方差分析,SNK-q进行统计学处理. 结果与0 mmol/L组比较,丹参素其他浓度组明显抑制了HSC增殖,并旱剂量依赖性.丹参素(0.0625~0.2500 mmol/L)对IL-1 β引起的HSC增殖具有明显的抑制作用,并呈剂量依赖性.0.25 mmol/L丹参素对正常培养的和经IL-1 β刺激的HSC作用24 h能下调Ⅰ型胶原的合成和分泌.IL-1 β能刺激ttSC中p-JNK的明显表达,丹参素能下凋亡IL-1 β诱导的ItSC中P-JNK的表达,但其对JNK表达水平没有明显影响. 结论丹参索可抑制正常传代培养的和经IL-1 β刺激的人鼠HSC增殖、Ⅰ型胶原合成与分泌,其机制可能与抑制JNK信号转导通路有关. 相似文献
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目的:探讨胃低张碳酸饮料充气法MSCT扫描在胃癌诊断及术前分期中的应用价值。方法:选择经胃镜检查确诊、并于1周后接受手术治疗的胃癌患者80例,将其随机分为2组:常规检查组和低张可乐组,每组各40例,其中常规检查组患者在CT检查前饮用清水,而低张可乐组患者饮用碳酸饮料。结果:常规检查组患者胃壁浸润深度的T1~T4分期结果总准确率为80%,而低张可乐组为85%;常规检查组患者淋巴结N0~N2转移诊断总准确率75%,而低张可乐组为95%;常规检查组远处转移的M0和M1诊断的总准确率为82.5%,而低张可乐组为97.5%。两者与手术病理诊断的一致性应用Kappa检验比较,低张可乐组的一致性显著高于常规检查组。结论:胃低张碳酸饮料充气法MSCT扫描较常规充气法明显提高了胃癌的诊断率,而且判断胃癌术前TNM分期与术后病理有较好的相关性,可为临床提供丰富信息,指导手术方案的选择。 相似文献
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目的:通过测量L1压缩椎体邻近椎小关节的角度、间隙,观察L1椎体压缩后邻近椎小关节的变化。探讨L1压缩椎体前后缘的比值与邻近椎小关节角度、间隙的关系。方法:应用64层螺旋CT对120例L1压缩椎体(压缩组)与有腰部疼痛但无L1椎体压缩的120例(对照组),进行邻近椎小关节结构及形态特点的对比分析。测量邻近椎小关节冠状位、矢状位、横断位的角度、间隙,将2组数据进行组间t检验分析。结果:以L1为中心,分为上下关节,以中轴线为中心,分为右、左关节。2组椎小关节的数据行统计学分析:冠状位角度差异无统计学意义(P值>0.05),矢状位、横断位角度差异均有统计学意义(P值<0.05);冠、矢、横断位椎小关节间隙的差异均无统计学意义(P值>0.05)。结论:L1椎体压缩骨折对邻近椎小关节间隙基本无影响;角度:冠状位基本无影响,横断位轻度变小,矢状位明显变小,但与椎体压缩程度不成比例。当矢状位上下椎弓根角(以L1为中心):上方<71.4°或下方<80.2°时,对胸腰段的生理曲度及脊柱的稳定性影响明显。 相似文献
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随着现代医学影像技术日新月异的发展,多排螺旋CT的开展利用,高压快速注射对比剂给诊断带来了越来越多的价值。怎样才能使高压快速增强扫描提供更准确更有效的信息呢?现分析如下。 相似文献
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Objective To investigate the inhibitory effect of danshensu on the activation of JNK signaling in rat hepatic stellate cells (HSCs) induced by IL-1 β. Methods The proliferation of primary rat HSCs treated with different concentration of Danshensu was checked by MTT colorimetric assay. The expres-sion and phosphorylation of JNK and P-JNK was detected by western blotting. Synthesis and secretion of collagen Ⅰ were detected by the quantitative immunocytochemical assay and ELISA. Results Danshensu inhibited the proliferation of HSCs in a dose-dependent manner. At the concentration of 0.0625 to 0.25 mmol/L, Danshensu significantly repressed the proliferation of HSC induced by IL-115 (P < 0.05). Synthesis and secretion of Type β collagen was significantly decreased 24 hours after 0.25 mmol/L Danshensu treatment (P < 0.01). The phosphorylation of JNK induced by IL-1 β was significantly inhibited by Danshensu treatment (P < 0.05), however, the expression of JNK was not regulated by Danshensu. Conelutions Danshensu represses the activation and proliferation of HSCs, and inhibits the synthesis and secretion of Type β collagen, possibly via the repression of the JNK signal transduction. 相似文献
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Objective To investigate the inhibitory effect of danshensu on the activation of JNK signaling in rat hepatic stellate cells (HSCs) induced by IL-1 β. Methods The proliferation of primary rat HSCs treated with different concentration of Danshensu was checked by MTT colorimetric assay. The expres-sion and phosphorylation of JNK and P-JNK was detected by western blotting. Synthesis and secretion of collagen Ⅰ were detected by the quantitative immunocytochemical assay and ELISA. Results Danshensu inhibited the proliferation of HSCs in a dose-dependent manner. At the concentration of 0.0625 to 0.25 mmol/L, Danshensu significantly repressed the proliferation of HSC induced by IL-115 (P < 0.05). Synthesis and secretion of Type β collagen was significantly decreased 24 hours after 0.25 mmol/L Danshensu treatment (P < 0.01). The phosphorylation of JNK induced by IL-1 β was significantly inhibited by Danshensu treatment (P < 0.05), however, the expression of JNK was not regulated by Danshensu. Conelutions Danshensu represses the activation and proliferation of HSCs, and inhibits the synthesis and secretion of Type β collagen, possibly via the repression of the JNK signal transduction. 相似文献