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儿童息性白血病由于化疗药物和治疗方案的改进和完善,长期存活率明显提高,但仍有许多患儿死于并发症。白血病回盲肠综合征是化疗期间重要并发症之一。1988年我们收治16例白血病,其中3例4次并发本病,特点为突然发热、腹痛、水样腹泻,右下腹部压痛,粒细胞降低0.3×10~9/L 以下,所有病例经保守疗法得到康复,应用广谱抗生素及支持疗法是十分重要的。 相似文献
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应用补体介导细胞毒法体外净化骨髓中残留白血病细胞后,对普通型急性淋巴细胞白血病(CALL)患者4例进行了自身骨髓移植(ABMT)。单个核细胞经单克隆抗体55(McAb 55)加兔补体两次处理后,CALL抗原阳性细胞清除率可达3个对数级,骨髓有核细胞及CFU-GM回收率分别为25.8%~64.8%和40.0%~62.4%,外周血白细胞于移植后第11~13天开始回升,15~29天升至10~9/L以上。第23~53天出洁净室,现无病存活时间分别为8~+、7~+,3~+和1.5个月,远期疗效仍在定期随访中。 相似文献
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我院小儿科于1988年7月年3月为两例小儿急性淋巴细胞性白血病(ALL)进行骨髓移植(ABMT)治疗,其中1例应用抗CALLA型McAB加兔补体体外净化骨髓现报告如下 :1诊断,临床及预处理方案,见附表 2.骨髓体外净化及输注使用抗CALLA型McAb_(55)加兔补体两次处理法净化骨髓。例1采集骨髓830ml,有核细胞总数为31.05×10~8,相当于病儿体重0.86×10~8/kg。净化处理后细胞回收率18.6%,置22℃~25℃室温保存52h后回输,因输注时悬液中细胞结成大块团絮状及输注反应严重,故细胞悬液再用生理盐水洗涤两次,通过四号针头形成单细胞悬液再静脉回输,未再反应,输入有核细胞数降到0.037×10~8/kg体重。因输有核细胞数量太少, 相似文献
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Two cases of β-thalassemia major treated with fetal liver transplanta-tion(FLT)were reported.A conditioning regimen of total body irradiation pluscyclophosphamide was given,followed by the infusion of suspensions of fetal livercells.The number of nucleated cells(procared from 3 to 4 fetal livers)infused tothe 2 cases was 17.5 and 15.5×10~8/kg respectively.Transient hemopoieticdepression was observed after FLT,and normal hemopoiesis was recoveredaround the 30th day.Karyotypic analysis revealed that the donor typechromosomes was founed in the peripheral blood of both cases from the 20th dayto 123rd day after FLT.Skin biopsy of cass 1 revealed changes of mild GVHD,indicating engrafment of fetal hemopoietic cells and formation of chimeras in thisperiod.Autologous hemopoiesis was reconstituted in both cases two months afterFLT.Blood transfusion was not necessary within the first 5 months after FLT,and in case 1 transfusion was given 3 times only within 21 months after FLT. 相似文献