肝假性动脉瘤破裂引起消化道出血1例及文献回顾

肝假性动脉瘤(hepatic artery pseudoaneurysm,HAP)以往被认为是一种罕见的肝脏疾病,但近年来由 于检查方法的不断进步,报道日趋增多.HAP破裂可引起胆道出血、腹腔大出血,病情危重,需急诊处理.本院 收治1例HAP破裂出血患者,现将其临床资料分析报道如下,同时结合文献,对HAP破裂出血的发病机制、临床表 现、诊断及治疗进行分析.     

泸州家庭居民幽门螺杆菌感染情况及相关危险因素分析

目的 为了了解泸州市居家居民HP感染情况及有关危险因素,为泸州市人群家庭HP感染防治提供一定策略及参考。方法 随机抽取泸州市市区203组家庭共510例人群,采用13C尿素呼气试验(UBT)来检测是否有HP感染,对调查人群的一般情况、生活中个人习惯和消化道相病史等相关问题展开问卷调查,然后对所得数据进行相关统计学分析,根据Hp感染情况提出相应的预防对策。结果 在510个研究人群中,有146例幽门螺旋杆菌阳性者,占总人数的28.63%,分布在105个家庭中,平均每户1.39例。全部调查对象中,家庭中无人感染占48.27%(98/203)、家庭中1人感染占34.98%(71/203)、家庭中2人感染占14.29%(29/203)、家庭中2例及以上感染占2.46%(5/203)。在所调查总体中,男性203例(39.80%),平均年龄(49.13±21.81)岁;女性307例(60.20%),平均年龄(51.30±16.70)岁;不同性别中,男性HP的阳性率比女性要高(P>0.05),其中男性占32.02%,女性占26.38%;对各年龄段泸州居民进行HP阳性率的统计学分析,结果显示年龄在4...     

血液透析膜生物相容性及在重症胰腺炎中的应用

BACKGROUND: Continuous blood purification can remove cytokines and inflammatory mediators, maintain homeostasis and prevent the occurrence of multiple organ dysfunction syndrome in patients with severe pancreatitis, which has become the main therapy for severe pancreatitis. Since the hemodialysis technology began to be applied clinically, the biological and physicochemical properties of hemodialysis membrane materials have been studied. A variety of hemodialysis membranes have been developed in order to improve the biocompatibility and anticoagulant effect in vitro. OBJECTIVE: To investigate the application effect of hemodialysis membranes on severe pancreatitis. METHODS: Ten Wistar rats were selected to make rat models of severe pancreatitis and then were randomized into two groups (n=5 per group): homophone membrane group and polysulfone membrane group. Hemodialysis- related biochemical parameters were detected in the two groups. RESULTS AND CONCLUSION: Compared with the homophone membrane, ultrafiltration coefficient, creatinine clearance, blood urea nitrogen clearance, phosphorus clearance, number of circulating endothelial cells, and levels of plasma nitric oxide and asymmetric dimethylarginine were significantly lower in the polysulfone membrane group (P < 0.05). Vitamin B12 clearance and amount of pre-congestion increased significantly in the polysulfone membrane group as compared with the homophone membrane (P < 0.05). These findings indicate that the polysulfone membrane for hemodialysis has good biocompatibility, and keeps a stable environment in vivo for severe pancreatitis patients.  中国组织工程研究杂志出版内容重点：生物材料;骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性;组织工程     

大鼠肝星状细胞大电导钙激活钾通道特性与细胞增殖的关系

目的探讨肝星状细胞（HSC）钙激活钾通道特性,以及钾通道对HSC增殖的影响。方法以胶原酶循环灌流法分离大鼠HSC,用结蛋白抗体及α-抗平滑肌抗体进行分离细胞鉴定,采用单通道细胞膜片钳技术检测传代HSC钾通道的特性,通过MTT法、流式细胞术分别检测钾离子通道阻滞剂四乙胺（TEA）对HSC的增殖、细胞周期的影响。结果所分离细胞为HSC。传代活化的HSC有单通道存在,其电导值为（210.86±5.49）pS（n=7）,属于大电导通道;其通道表现出明显的电压依赖性以及对钙敏感性,TEA可明显减少外向钾离子通道开放概率。TAE对HSC的增殖抑制效应具有时间依赖与剂量依赖的特点,可使细胞周期阻滞于G0/G1期。结论 HSC上大电导钙激活钾通道可能参与了HSC活化增殖。