胫骨平台骨折分型的螺旋CT三维重建应用和临床价值

目的 :探讨螺旋CT三维重建 (3DCT)对胫骨平台骨折分型的影响及在胫骨平台骨折中的临床应用价值。方法 :收集经手术治疗的胫骨平台骨折 2 6例 ,所有患者术前均接受X线片检查 ,同时行螺旋CT扫描和三维重建及多平面重建。根据Schatker分类法对胫骨平台骨折进行分型 ,比较X线片和 3DCT两种方法对胫骨平台骨折分型诊断的正确率 ,并评价 3DCT在胫骨平台骨折治疗中的应用。结果 :经手术证实 ,2 6例胫骨平台骨折按Schatker分类法 :Ⅰ型 :劈裂骨折 (1例 ) ;Ⅱ型 :塌陷骨折 (2例 ) ;Ⅲ型 :劈裂及塌陷 (17例 ) ;Ⅳ型 :涉及胫骨嵴的平台骨折 (3例 ) ;Ⅴ型 :内外侧平台Y型骨折 (2例 ) ;Ⅵ型 :胫骨平台和胫骨上 1/3段联合骨折 (1例 )。普通X线片对胫骨平台骨折分型的正确率为 76 92 % ,螺旋CTSSD、MPR结合二维CT横切面图像对胫骨平台骨折分型的正确率为 10 0 % ,两者比较有显著差异 (P <0 .0 5 ) ,所有 3DCT资料均对治疗具有指导作用。结论 :3DCT对胫骨平台骨折分型及决定治疗方案有重要的指导作用     

RGD多肽接枝聚复合导管桥接神经缺损的实验研究

Objective To investigate the effect of RGD peptide conjugated poly[ LA-(Glc-Lys) ]/βTCP/PLA nerve conduit for bridging peripheral nerve regeneration defect. Methods Forty-five male Wister rots were randomly divided into 3 groups, with 15 rats each. A 10 mm defect was created in the right sciatic nerve. In group A the gap was bridged by PLA tube. In group B RGD peptide conjugated poly[ LA-(Glc-Lys) ]/β-TCP/PLA nerve conduit was used to repair the defect. Autologous nerve graft was done in group C which served as control. Twelve weeks postoperatively nerve regeneration was evaluated by gross observation,electrophysiology, muscle weight and muscle morphometry of triceps surae, and ultrastructure of the regenerating nerve. Results Twelve weeks after the operation, nerve conduction velocity and muscle weight recovery of group B were better than those of group A. The differences were statistically significant( P < 0.05). There was no significant difference between group B and group C ( P > 0. 05). The results of histology and ultrastructure showed that nerve regeneration in group B and group C was significantly superior to that in group A.Conclusion RGD peptide conjugated poly[LA-(Glc-Lys)]/β-TCP/PLA conduit can achieve similar results in repairing sciatic nerve defect to that of autogentic nerve graft. It may be an ideal material to repair nerve defect.     

益气活血法治疗慢性肾炎蛋白尿46例

目的:观察益气活血法治疗慢性肾炎蛋白尿的临床疗效。方法:选取46例患者,采用复方丹参注射液20ml、黄芪注射液20ml加入5%葡萄糖注射液250ml中静滴,日1次,28d为1个疗程。结果:完全缓解90例(19.57%),部分缓解16例(34.78%),有效15例(32.61%),无效6例(13.04%),有效率为89.1%。结论:益气活血法治疗慢性肾炎蛋白尿疗效确切。     

当归与东当归的鉴别

今发现有用东当归(Angelica acutiloba Sieb.et Zucc.)的根充当归头使用。东当归主要在吉林延边地区栽培、收购、使用,为地区习惯用药,质量较次。现将两者主要性状鉴别特征介绍如下,以供参考。当归:根略呈圆柱形,表面黄棕色或棕色,有明显纵皱纹及横长皮孔。主根粗短,根     

RGD多肽接枝聚复合导管桥接神经缺损的实验研究

Objective To investigate the effect of RGD peptide conjugated poly[ LA-(Glc-Lys) ]/βTCP/PLA nerve conduit for bridging peripheral nerve regeneration defect. Methods Forty-five male Wister rots were randomly divided into 3 groups, with 15 rats each. A 10 mm defect was created in the right sciatic nerve. In group A the gap was bridged by PLA tube. In group B RGD peptide conjugated poly[ LA-(Glc-Lys) ]/β-TCP/PLA nerve conduit was used to repair the defect. Autologous nerve graft was done in group C which served as control. Twelve weeks postoperatively nerve regeneration was evaluated by gross observation,electrophysiology, muscle weight and muscle morphometry of triceps surae, and ultrastructure of the regenerating nerve. Results Twelve weeks after the operation, nerve conduction velocity and muscle weight recovery of group B were better than those of group A. The differences were statistically significant( P < 0.05). There was no significant difference between group B and group C ( P > 0. 05). The results of histology and ultrastructure showed that nerve regeneration in group B and group C was significantly superior to that in group A.Conclusion RGD peptide conjugated poly[LA-(Glc-Lys)]/β-TCP/PLA conduit can achieve similar results in repairing sciatic nerve defect to that of autogentic nerve graft. It may be an ideal material to repair nerve defect.     

高血压脑出血患者肿瘤坏死因子-α和白细胞介素-6活性水平的观察

高血压脑出血患者肿瘤坏死因子α和白细胞介素６活性水平的观察张淑姚智邢复明芦奕曾宪起张毅勾俊龙华勇本研究系天津市卫生局重点科研基金资助项目，并曾在脑血管疾病研究进展国际交流会上交流作者单位：３００２５０天津天津市第三医院老年医学研究所神经外科（张淑?..     

RGD多肽接枝聚复合导管桥接神经缺损的实验研究

Objective To investigate the effect of RGD peptide conjugated poly[ LA-(Glc-Lys) ]/βTCP/PLA nerve conduit for bridging peripheral nerve regeneration defect. Methods Forty-five male Wister rots were randomly divided into 3 groups, with 15 rats each. A 10 mm defect was created in the right sciatic nerve. In group A the gap was bridged by PLA tube. In group B RGD peptide conjugated poly[ LA-(Glc-Lys) ]/β-TCP/PLA nerve conduit was used to repair the defect. Autologous nerve graft was done in group C which served as control. Twelve weeks postoperatively nerve regeneration was evaluated by gross observation,electrophysiology, muscle weight and muscle morphometry of triceps surae, and ultrastructure of the regenerating nerve. Results Twelve weeks after the operation, nerve conduction velocity and muscle weight recovery of group B were better than those of group A. The differences were statistically significant( P < 0.05). There was no significant difference between group B and group C ( P > 0. 05). The results of histology and ultrastructure showed that nerve regeneration in group B and group C was significantly superior to that in group A.Conclusion RGD peptide conjugated poly[LA-(Glc-Lys)]/β-TCP/PLA conduit can achieve similar results in repairing sciatic nerve defect to that of autogentic nerve graft. It may be an ideal material to repair nerve defect.     

RGD多肽接枝聚复合导管桥接神经缺损的实验研究

目的 探讨RGD多肽接枝聚/β-TCP/PLA复合神经导管桥接周围神经缺损的治疗效果.方法 45只雄性成年Wister大鼠,随机分为3组,每组15只.切断右侧坐骨神经形成10 mm缺损,A组采用单纯PLA神经导管桥接缺损,B组采用RGD多肽接枝聚/β-TCP/PLA复合神经导管桥接缺损,C组采用自体神经移植.术后12周进行大体观察、电生理、小腿三头肌恢复率、组织学、超微结构等测定.结果 B组运动神经传导速度和肌肉湿重恢复率明显优于A组,差异有统计学意义(P<0.05);B组与C组相近,差异无统计学意义(P>0.05).组织学、超微结构测定发现B、C组神经再生情况明显优于A组.结论 在坐骨神经损伤修复中,RGD多肽接枝聚/β-TCP/PLA复合神经导管桥接修复效果与自体神经移植相近,可作为一种较理想的神经缺损修复材料.