东菱克栓酶对沙土鼠缺血性脑血管病引起的脑水肿的影响

以结扎左侧颈总动脉（ＬＣＣＡ）的沙土鼠为缺血性脑卒中动物模型，观察东菱克栓酶（ＴＯＢＩＳＨＩ ＤＦ－５２１）对缺血性脑卒中的保护作用以及对缺血性脑水肿的影响。发现：东菱克栓酶可显著降低缺血性座中动物的轻、重症状包括死亡的发生，且脑卒中分数与大脑皮层脑组织的比重呈显著负相关。本文结果提示：东菱克栓酶对缺血性脑卒中的保护作用之一，可能与它能减轻脑缺血性脑水肿有关。     

局灶性脑缺血的治疗进展

脑血管意外的死亡率及致残率都十分高,其中缺血性卒中占脑血管意外的43～65%。因之,缺血性脑血管病的病因、诊断与治疗日益受到重视,尤其是治疗恰当与否,关系到能否降低死亡率与致残率,兹将局灶性脑缺血的治疗进展简要介绍如下。     

丛集性头痛的近期研究

丛集性头痛的近期研究２５００３１济南济南军区总医院郭述苏匡培根关键词丛集性头痛；治疗学中国图书资料分类号Ｒ７４７．２丛集性头痛（ｃｌｕｓｔｅｒｈｅａｄａｃｈｅ，ＣＨ）是最严重的头痛类型之一，对其病因及发病机制至今仍有争论。１９８８年国际头痛学会修定诊...     

THE EFFECT OF RADIX SALVIAE MILTIORRHIZAE COMPOSITA ON PEROXIDATION OF LOW DENSITY LIPOPROTEIN DUE TO COPPER DICHLORIDE

It is well known that plasma lipoprotein, particularly oxidized LDL, plays an important rolein the pathogenesis of atherosclerosis and atherosclerotic diseases. We used oxidized LDLgenerated by incubating LDL from healthy Persons with copper dichloride as a model to in-vestigate the antioxidate property of Radix Salviae Miltiorrhizae Composita (RSMC). Onphotos, the spot X1 and the spot X2 were clearly found in the control group after the dislysisinto copper dichloride for 24 and 48 hours, but they could not found in the RSMC group.The analysis of the constituents of lipids in LDL (by charring method) showed that afterdislysis the percentages of the spot X1 and the spot X2 in the RSMC group weresignificantly lower tban those in the control group (P< 0.01). The results suggest thatRSMC plays a potential role in antioxidation of lipuls or LDL.     

脑梗死大鼠磁共振T2加权像和氢磷谱的变化及丹参的作用

目的研究脑梗死后脑组织的物质和能量代谢的变化及丹参在脑梗死治疗中的作用。方法 18只 SD 大鼠随机分成梗死组、丹参组和假手术组3组,梗死组和丹参组用光化学法诱导颞叶皮层梗死.假手术组仅手术暴露颞骨。丹参组于诱导梗死前10min 腹腔注射丹参注射液5g/kg,于24、48h 按此剂量各再给药1次,假手术组和梗死组大鼠腹腔注射生理盐水;然后运用磁共振成像和波谱技术,观察脑梗死后1、3、5、7天磁共振 T2加权像和氢磷谱的动态变化以及丹参的作用。结果假手术组大鼠颞叶皮层的 T2加权像信号正常,梗死组大鼠颞叶皮层出现一高信号区。于梗死后3、5、7天,梗死组大鼠该区的 NAA/Cho 加 Cr 与假手术组比较,差异均有显著性(P<0.05);假手术组的 Lac 一直处于检测水平线以下,而梗死组高信号区的 Lac 于梗死后1、3、5、7天均可检测到。于梗死后1、3和5天,梗死组大鼠全脑的βATP/PME 加 PDE 和 PCr/PME 加PDE 与假手术组比较,差异均有显著性(P<0.05);于梗死后1天,梗死组大鼠全脑的βATP/PCr 与假手术组比较,差异有显著性(P<0.05)。而丹参能减小梗死大鼠梗死后1、3、...     

颈动脉综合征(文献综述)

在Hippocrates(五世纪)时代之前,人们已经知道用手指压迫一侧或两侧总颈动脉有时可产生失语、偏瘫和意识丧失。1664年Willis已认识到有时颈内动脉闭塞可不产生任何影响。但对颈动脉疾病引起神经系统症状的详细了解还仅仅是近30年的事,Hultquist(1942)提示了在颈动脉闭塞时的病理学特征,Fisher(1951,1954)二次详细描述了颈动脉疾病的临床表现。近年来人们已进一步认识到在脑血管疾病中,缺血性脑血管病为常见,Kurtzke(1969)报告其发病率占脑血管病的62％,越来越多的例证表明在颈部     

年龄对脑电阻图的影响(附136名健康人资料分析)

脑电阻图是一种简易检测方法,作为对脑部血管疾病的辅助检查,六十年代已开始应用于临床,迄今在国内已被广泛采用;但目前对其评价不一,尤其是由于年龄因素,如何评价所得结果?所用指标又较多,但何种指标较为可靠?本文拟针对上述问题,进行探索。对象和方法我们选择不同年龄的健康人共136例,其中男性98例,女性68例;年龄最小5岁,最大58岁。采用意大利制officine GalileoECG model C2a Rheopreamp model 152z双     

THE EFFECT OF RADIX SALVIAE MILTIORRHIZAE ON VASOACTIVE INTESTINAL PEPTIDE IN CEREBRAL ISCHEMIA:AN ANIMAL EXPERIMENT

The levels of vasoactive intestinal peptide(VIP)in three regions of rat brain were assayed in 62 rats.Bilateral common carotid artery ligation was donein 50 rats.Half an hour before ligation 26 rats weregiven 10 g/kg of Radix Salviae Miltiorrhizae(RSM);24 rats were given same volume of normalsaline as controls.A sham operation wasdone in 12 rats.Half an hour(n=30)and 3hours(n=32)after operation,the rats were quicklydecapitated.VIP levels were assayed in cerebralcortex,hippocampus and caudate nucleus,in salin-treated animals,VIP levels of cerebral cortex andcaudate nucleus at 3 hour group were significantlydecreased compared with the sham-operated group.No significant difference was found between RSM-treated and sham-operated groups.The preliminaryresults suggest that VIP may be involved in thepathophysiological procedures of cerebral ischemiaand RSM may attenuate the dysfunction of VIPduring cerebral ischemia.     

34例急性脑卒中血浆血栓素B_2(TXB_2)放免测定的动态分析

前列腺素Ⅰ_2(PGI_2)和血栓素 A_2(TXA_2)对维持机体血管功能完整的内环境稳定具有重要意义。在正常生理状态下,循环血液中的 PGI_2和 TXA_2含量处于相对平衡状态。当平衡失调时,即易引起心、脑血管多种疾病。而 TXA_2是具有强烈血管收缩及促血小板凝集的活性物质,半衰期仅30秒钟,即迅速代谢为无活性的血栓素发 B_2(TXB_2)。故测定血浆 TXB_2含量,在基础医学和药理学的研究,以及对临床上脑卒中的发病机理及防治探讨具有重要意义。目前国内外文献未见到有关