全文获取类型
收费全文 | 1623篇 |
免费 | 107篇 |
专业分类
耳鼻咽喉 | 8篇 |
儿科学 | 11篇 |
妇产科学 | 12篇 |
基础医学 | 317篇 |
口腔科学 | 52篇 |
临床医学 | 212篇 |
内科学 | 324篇 |
皮肤病学 | 23篇 |
神经病学 | 90篇 |
特种医学 | 37篇 |
外科学 | 170篇 |
综合类 | 1篇 |
预防医学 | 99篇 |
眼科学 | 17篇 |
药学 | 243篇 |
中国医学 | 3篇 |
肿瘤学 | 111篇 |
出版年
2023年 | 14篇 |
2022年 | 11篇 |
2021年 | 40篇 |
2020年 | 20篇 |
2019年 | 45篇 |
2018年 | 61篇 |
2017年 | 36篇 |
2016年 | 50篇 |
2015年 | 62篇 |
2014年 | 79篇 |
2013年 | 147篇 |
2012年 | 185篇 |
2011年 | 208篇 |
2010年 | 151篇 |
2009年 | 49篇 |
2008年 | 33篇 |
2007年 | 24篇 |
2006年 | 22篇 |
2005年 | 12篇 |
2004年 | 9篇 |
2003年 | 14篇 |
2002年 | 18篇 |
2001年 | 14篇 |
2000年 | 24篇 |
1999年 | 15篇 |
1997年 | 22篇 |
1994年 | 8篇 |
1993年 | 9篇 |
1992年 | 10篇 |
1991年 | 17篇 |
1990年 | 7篇 |
1989年 | 15篇 |
1988年 | 14篇 |
1987年 | 11篇 |
1986年 | 13篇 |
1985年 | 7篇 |
1984年 | 19篇 |
1983年 | 12篇 |
1982年 | 15篇 |
1981年 | 18篇 |
1980年 | 10篇 |
1979年 | 10篇 |
1978年 | 11篇 |
1977年 | 16篇 |
1976年 | 20篇 |
1974年 | 7篇 |
1972年 | 11篇 |
1971年 | 8篇 |
1967年 | 12篇 |
1965年 | 9篇 |
排序方式: 共有1730条查询结果,搜索用时 15 毫秒
1.
2.
Éktova L. V. Goryunova O. V. Eremina V. A. Tikhonova N. I. Medvedeva L. A. 《Pharmaceutical Chemistry Journal》2019,53(7):604-609
Pharmaceutical Chemistry Journal - Use of formylindolylacetic acid as a reagent at the stage of preparing the glycosides of bis(indolyl)furan-2,5-diones and dioxane as solvent increased yields from... 相似文献
3.
4.
5.
6.
Chelyabinsk Medical Institute. (Presented by Academician of the Academy of Medical Sciences of the USSR A. D. Ado.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 113, No. 3, pp. 299–301, March, 1992. 相似文献
7.
The 22 kDa fragment (Asn1-Met171) purified from iodine-poor human thyroglobulin (hTg) is capable by itself to synthesize thyroxine at Tyr5, the preferential hormonogenic acceptor site of the protein, after iodination in vitro. To identify the corresponding donor site in this model we studied the fate of the six Tyr residues present in the 22 kDa peptide after in vitro hormone synthesis. Structural studies of the tyrosyl peptides showed that Tyr5 was the only thyroxine-forming site, the other tyrosines (29, 89, 97 and 107) were noniodinated and Tyr130 was recovered in alanine form after CNBH4 treatment of the Tyr130-containing peptide. Taking into account that alanine could arise from aminoreduced pyruvate species, these results showed that in the 22 kDa fragment (1) hormone formation involves the couple Tyr5 (acceptor)-Tyr130 (donor), and (2) dehydroalanine, the resultant product of donor tyrosine after hormone synthesis, has evolved in pyruvoyl form. To test whether Tyr130 could also act as donor in hTg hormone synthesis, the 22 kDa peptide was isolated from hTg iodinated under conditions leading to iodotyrosine formation followed or not by hormone formation and the tyrosyl peptides were analyzed. After hTg iodination and before coupling (i.e. hormone synthesis) only Tyr5 and Tyr130 were recovered in iodotyrosine form; after coupling thyroxine was found at Tyr5 whereas Tyr130 disappeared. Taken together these results, correlated with the previously reported cleavage of hTg chain at Tyr130 occurring during in vivo hormone synthesis, support the theory that the couple Tyr5 (acceptor)-Tyr130 (donor) would be the preferential hormonogenic site in human Tg. 相似文献
8.
E. A. Érenpreisa R. A. Zirne N. D. Zaleskaya T. G. Sjakste 《Bulletin of experimental biology and medicine》1988,106(5):1605-1608
Laboratory of Chemistry of the Cancer Cell, Latvian Research Institute of Experimental and Clinical Medicine, Ministry of Health of the Latvian SSR, Riga. (Presented by Academician of the Academy of Medical Sciences of the USSR I. B. Zbarskii.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 106, No. 11, pp. 591–593, November, 1988. 相似文献
9.
Transjugular intrahepatic portosystemic shunt before abdominal surgery in cirrhotic patients: a retrospective, comparative study. 总被引:1,自引:0,他引:1
Evelyne Vinet Pierre Perreault Louis Bouchard Denis Bernard Ramses Wassef Carole Richard Richard Létourneau Gilles Pomier-Layrargues 《Journal canadien de gastroenterologie》2006,20(6):401-404
Surgery in cirrhotic patients is associated with high morbidity and mortality related to portal hypertension and liver insufficiency. Therefore, preoperative portal decompression is a logical approach to facilitate abdominal surgery and hopefully to improve postoperative survival. The present study evaluated the clinical outcomes of 18 patients (mean age 58 years) with cirrhosis (seven alcoholics and 11 nonalcoholics) who underwent transjugular intrahepatic portosystemic shunt (TIPS) placement before antrectomy (n=5), colectomy (n=10), small-bowel resection (n=1), pancreatectomy (n=1) and nephrectomy (n=1). TIPS was performed a mean (+/-SD) of 72+/-21 days before surgery and induced a marked mean decrease in portohepatic gradient from 21.4+/-3.9 mmHg to 8.4+/-3.4 mmHg. Cirrhotic patients (n=17) who underwent elective abdominal surgery without preoperative TIPS placement were used as the control group. Both groups were matched for age, etiology of cirrhosis, indications for surgery, type of surgery and coagulation parameters. The mean Pugh score was significantly higher in the TIPS group (7.7 versus 6.2). No significant differences were observed for operative blood loss, postoperative complications, duration of hospitalization and one-month (83% versus 88%) or one-year (54% versus 63%) cumulative survival rate. Analysis using the Cox proportional hazards model showed that neither TIPS placement nor preoperative Pugh score were independent predictors for survival. The present study suggests that preoperative TIPS placement does not improve postoperative evolution after abdominal surgery in cirrhotic patients with good or moderately impaired liver function. 相似文献
10.