全文获取类型
收费全文 | 10107484篇 |
免费 | 630189篇 |
国内免费 | 161297篇 |
专业分类
耳鼻咽喉 | 130763篇 |
儿科学 | 282305篇 |
妇产科学 | 231692篇 |
基础医学 | 1253746篇 |
口腔科学 | 264441篇 |
临床医学 | 1022407篇 |
内科学 | 1696918篇 |
皮肤病学 | 203672篇 |
神经病学 | 730397篇 |
特种医学 | 377159篇 |
外国民族医学 | 1661篇 |
外科学 | 1330562篇 |
综合类 | 706265篇 |
现状与发展 | 513篇 |
一般理论 | 3725篇 |
预防医学 | 811312篇 |
眼科学 | 230348篇 |
药学 | 864579篇 |
2777篇 | |
中国医学 | 209964篇 |
肿瘤学 | 543764篇 |
出版年
2023年 | 53704篇 |
2022年 | 131412篇 |
2021年 | 200485篇 |
2020年 | 143169篇 |
2019年 | 146056篇 |
2018年 | 178121篇 |
2017年 | 158458篇 |
2016年 | 152507篇 |
2015年 | 189357篇 |
2014年 | 277341篇 |
2013年 | 369002篇 |
2012年 | 521944篇 |
2011年 | 566033篇 |
2010年 | 383452篇 |
2009年 | 345027篇 |
2008年 | 482020篇 |
2007年 | 502341篇 |
2006年 | 479565篇 |
2005年 | 441555篇 |
2004年 | 388471篇 |
2003年 | 360116篇 |
2002年 | 332001篇 |
2001年 | 312101篇 |
2000年 | 310737篇 |
1999年 | 266227篇 |
1998年 | 111118篇 |
1997年 | 97677篇 |
1996年 | 91662篇 |
1995年 | 83752篇 |
1994年 | 75901篇 |
1993年 | 64896篇 |
1992年 | 182870篇 |
1991年 | 176910篇 |
1990年 | 171615篇 |
1989年 | 166566篇 |
1988年 | 153990篇 |
1987年 | 150064篇 |
1986年 | 142874篇 |
1985年 | 136127篇 |
1984年 | 103663篇 |
1983年 | 88999篇 |
1982年 | 56686篇 |
1979年 | 93065篇 |
1978年 | 66785篇 |
1977年 | 57591篇 |
1975年 | 58434篇 |
1974年 | 67404篇 |
1973年 | 64316篇 |
1972年 | 59445篇 |
1971年 | 55067篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
1.
Rizzo Manglio Miguel Bluthgen Mara Virginia Recondo Gonzalo Naveira Martin Perfetti Aldo Rizzi Florencia Kuzminin Alejandro Faura Victoria Cerini Matas Videla Alejandro Silva Carlos Lupinacci Lorena Minatta Nicols 《International journal of clinical oncology / Japan Society of Clinical Oncology》2021,26(6):1057-1064
International Journal of Clinical Oncology - Immune-checkpoint inhibitors (ICIs) are standard treatments for metastatic non-small cell lung cancer (NSCLC). Patients with poor performance status... 相似文献
2.
3.
4.
Anela Stanic Denis Rybin Francis Cannata Carole Hohl Jennifer Brody Jessie Gaeta 《AIDS care》2021,33(1):1-9
ABSTRACT The lack of stable housing can impair access and continuity of care for patients living with human immunodeficiency virus (HIV). This study investigated the relationship between housing status assessed at multiple time points and several core HIV-related outcomes within the same group of HIV patients experiencing homelessness. Patients with consistently stable housing (CSH) during the year were compared to patients who lacked CSH (non-CSH group). The study outcomes included HIV viral load (VL), CD4 counts, and health care utilization. Multivariable and propensity weighted analyses were used to assess outcomes adjusting for potential group differences. Of 208 patients, 88 (42%) had CSH and 120 (58%) were non-CSH. Patients with CSH had significantly higher proportion of VL suppression and higher mean CD4 counts. The frequency of nurse visits in the CSH group was less than a half of that in the non-CSH group. Patients with CSH were less likely to be admitted to the medical respite facility, and if admitted, their length of stay was about a half of that for the non-CSH group. Our study findings show that patients with CSH had significantly better HIV virologic control and immune status as well as improved health care utilization. 相似文献
5.
6.
7.
Depeng Meng Yichen Meng Bingyang Li Guigang Zeng Bin Zhang Chunlin Hou Haodong Lin Yueping Ouyang 《Journal of orthopaedic science》2021,26(3):409-414
BackgroundComminuted patellar fractures are not rare, and the ideal treatment method remains controversial. The present study was conducted to evaluate effects and compare complications of two different methods used to treat comminuted patellar fractures.MethodsFrom March 2010 to August 2016, 102 cases of 34-C2 or 34-C3 comminuted patellar fractures were treated at our hospital, wherein patients received two different treatments: titanium cable tension band with cerclage method (group A) and intrafragmentary screws with X-shaped plating technique (group B). At follow-ups, articular step-off, range of motion (ROM), Lysholm scores, time of union, and complications were recorded and analyzed. Radiographic and clinical data as well as rate of complications were statistically analyzed.ResultsIn total, 87 patients were included in the final analysis (n = 47 in group A and n = 40 in group B). No significant differences were noted in terms of cost of implant, age, gender, rate of 34-C3 fractures, rate of layered inferior pole fractures, postoperative articular step-off and union time. At 2-year follow-up, average Lysholm scores, ROM and rate of complications were (89.0 ± 4.5), (122°±12°) and (27.7%) in group A and (90.2 ± 3.9), (124°±11°) and (17.5%) in group B, respectively, with no significant differences (p > 0.05). The mean time of surgery in group B was shorter than that in group A with significant difference (p < 0.05).ConclusionsTreatment using the intrafragmentary screws and plate method for amenable comminuted patellar fractures achieved similar complication rate and favorable functional outcomes at the 2-year follow-up, which was comparable to the titanium cable tension band with cerclage method. Thus, the intrafragmentary screws and plate method is effective, safe and convenient for 34-C2/C3 comminuted patellar fractures, especially appropriate for patients with layered fragments. 相似文献
8.
9.
10.
Bortezomib is a novel proteasome inhibitor, which has been successfully used to treat mantle cell lymphoma and multiple myeloma. However, the direct effects of bortezomib on acute promyelocytic leukaemia (APL) have not been fully investigated. In the present study, the WST-8 assay, western blotting, flow cytometry, monodansylcadaverine staining and transmission electron microscopy were performed. It was demonstrated that bortezomib treatment induced a time- and dose-dependent decrease in the viability of NB4 cells. Bortezomib treatment induced cell apoptosis in NB4 cells, as assessed by Annexin V/propidium iodide analysis, and the detection of cleaved caspase-3, cleaved poly(ADP-ribose) polymerase, Bax and Bcl-2 expression. Furthermore, bortezomib treatment induced autophagy in NB4 cells, as indicated by autophagosome formation, p62 degradation, LC3-I to LC3-II conversion and formation of acidic autophagic vacuoles. Notably, autophagy induced by bortezomib was initiated prior to apoptosis. Inhibition of autophagy by knocking down Beclin-1 expression increased bortezomib-induced apoptosis in NB4 cells. Therefore, the present study revealed that the combination of bortezomib and autophagy inhibition may be a potential treatment strategy for APL. 相似文献